Myocardial Response to Biomechanical Stress

Biomechanical stress of the myocardium is the situation resulting from hypoxia, hypertension, and other forms of myocardial injury, that invariably lead to increased demands for cardiac work and/or loss of functional myocardium. As a consequence of biomechanical stress a number of responses develop...

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Autores: Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41, Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0, Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515, Ardanaz, N. (Noelia)|||/items/ff06d888-ff49-4b35-bcd6-613890f99535, Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9
Tipo de recurso: artículo
Fecha de publicación:2001
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:español
OAI Identifier:oai:dadun.unav.edu:10171/21958
Acceso en línea:https://hdl.handle.net/10171/21958
Access Level:acceso abierto
Palabra clave:Apoptosis
Biomechanical stress
Fibrosis
Heart failure
Hypertrophy
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spelling Myocardial Response to Biomechanical StressDiez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515Ardanaz, N. (Noelia)|||/items/ff06d888-ff49-4b35-bcd6-613890f99535Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9ApoptosisBiomechanical stressFibrosisHeart failureHypertrophyBiomechanical stress of the myocardium is the situation resulting from hypoxia, hypertension, and other forms of myocardial injury, that invariably lead to increased demands for cardiac work and/or loss of functional myocardium. As a consequence of biomechanical stress a number of responses develop involving all the myocardial cells, namely cardiomyocytes. As a result some myocardial phenotypic changes develop that are initially compensatory (i.e., hypertrophy) but which may mediate the eventual decline in myocardial function that occurs with the transition from hypertrophy to failure in conditions of persistent stress (i.e., apoptosis and fibrosis). This review focuses on the steps involved in the response of the myocardium to biomechanical stress and highlights the most recent developments in the molecular mechanisms involved in the development of heart failure.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20122012-05-0820012001-01-0120012001-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/21958reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/219582026-06-21T12:47:57Z
dc.title.none.fl_str_mv Myocardial Response to Biomechanical Stress
title Myocardial Response to Biomechanical Stress
spellingShingle Myocardial Response to Biomechanical Stress
Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41
Apoptosis
Biomechanical stress
Fibrosis
Heart failure
Hypertrophy
title_short Myocardial Response to Biomechanical Stress
title_full Myocardial Response to Biomechanical Stress
title_fullStr Myocardial Response to Biomechanical Stress
title_full_unstemmed Myocardial Response to Biomechanical Stress
title_sort Myocardial Response to Biomechanical Stress
dc.creator.none.fl_str_mv Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41
Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0
Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515
Ardanaz, N. (Noelia)|||/items/ff06d888-ff49-4b35-bcd6-613890f99535
Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9
author Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41
author_facet Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41
Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0
Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515
Ardanaz, N. (Noelia)|||/items/ff06d888-ff49-4b35-bcd6-613890f99535
Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9
author_role author
author2 Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0
Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515
Ardanaz, N. (Noelia)|||/items/ff06d888-ff49-4b35-bcd6-613890f99535
Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Apoptosis
Biomechanical stress
Fibrosis
Heart failure
Hypertrophy
topic Apoptosis
Biomechanical stress
Fibrosis
Heart failure
Hypertrophy
description Biomechanical stress of the myocardium is the situation resulting from hypoxia, hypertension, and other forms of myocardial injury, that invariably lead to increased demands for cardiac work and/or loss of functional myocardium. As a consequence of biomechanical stress a number of responses develop involving all the myocardial cells, namely cardiomyocytes. As a result some myocardial phenotypic changes develop that are initially compensatory (i.e., hypertrophy) but which may mediate the eventual decline in myocardial function that occurs with the transition from hypertrophy to failure in conditions of persistent stress (i.e., apoptosis and fibrosis). This review focuses on the steps involved in the response of the myocardium to biomechanical stress and highlights the most recent developments in the molecular mechanisms involved in the development of heart failure.
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01
2001
2001-01-01
2012
2012-05-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/21958
url https://hdl.handle.net/10171/21958
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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