Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders

Objective: The processing speed (PS) is highly impacted in individuals experiencing their first episode of psychosis (FEP). Conducting family studies can help to determine whether PS can serve as an endophenotype of schizophrenia spectrum disorders (SSDs), offering valuable insights into the prevent...

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Autores: Yorca Ruiz, Ángel, Murillo García, Nancy, Magdaleno Herrero, Rebeca, Díaz Pons, Alexandre, Ortiz-García de la Foz, Víctor, Fernández Cacho, Luis Manuel, López Fanarraga, Mónica|||0000-0003-4754-311X, Ayesa Arriola, Rosa
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/34277
Acceso en línea:https://hdl.handle.net/10902/34277
Access Level:acceso abierto
Palabra clave:First-episode
First-degree relatives
Psychosis
Processing speed
Endophenotype
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spelling Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disordersYorca Ruiz, ÁngelMurillo García, NancyMagdaleno Herrero, RebecaDíaz Pons, AlexandreOrtiz-García de la Foz, VíctorFernández Cacho, Luis ManuelLópez Fanarraga, Mónica|||0000-0003-4754-311XAyesa Arriola, RosaFirst-episodeFirst-degree relativesPsychosisProcessing speedEndophenotypeObjective: The processing speed (PS) is highly impacted in individuals experiencing their first episode of psychosis (FEP). Conducting family studies can help to determine whether PS can serve as an endophenotype of schizophrenia spectrum disorders (SSDs), offering valuable insights into the prevention and diagnosis of SSDs. Method: A comprehensive cognitive battery, encompassing tests for PS, verbal memory, visual memory, working memory, executive functions, motor dexterity, and attention, was administered to a sample consisting of 133 FEP patients, 146 parents, 98 siblings, and 202 healthy controls (HCs). Univariate analyses (analysis of covariance [ANCOVA]) were conducted to compare the different cognitive domains between groups, utilizing sex, age, and years of education as covariates and Bonferroni corrections. Effect sizes (ESs) were calculated for estimating the magnitude of differences between groups. Results: Group comparisons revealed significant differences in all cognitive domains. PS was the most impaired function in patients. Parents and siblings had intermediate PS performance between FEP patients and HC. Large ES were observed in PS between FEP versus siblings, FEP versus controls, parents versus controls, and parents versus siblings. Conclusions: Despite not meeting all the necessary criteria, the PS observed in FEP patients and their first-degree relatives suggests its potential as a promising endophenotype of SSDs.Funding statement: The PAFIP project carried out on Marqués de Valdecilla Research Institute was supported by the Carlos III Health Institute (PI14/00639 and PI14/00918). In addition, this work was financed by a Miguel Servet from the Carlos III Health Institute contract (Dra. Rosa Ayesa-Arriola) (CP18/00003), and a predoctoral contract (Ángel Yorca Ruiz) (PFIS: FI/00162) from the Valdecilla Biomedical Research Institute and the University of Cantabria. No pharmaceutical company has financially supported the study. Acknowledgement: The authors wish to thank all “Programa de Atención a Fases Iniciales de Psicosis” (PAFIP) research team, and especially to all patients and family members who participated in the study.American Psychological AssociationUniversidad de Cantabria20242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/34277Neuropsychology, 2024, 38(4), 357-367reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/342772026-06-02T12:39:31Z
dc.title.none.fl_str_mv Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
title Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
spellingShingle Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
Yorca Ruiz, Ángel
First-episode
First-degree relatives
Psychosis
Processing speed
Endophenotype
title_short Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
title_full Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
title_fullStr Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
title_full_unstemmed Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
title_sort Processing speed in first episode of psychosis and first-degree relatives: a candidate endophenotype of spectrum schizophrenia disorders
dc.creator.none.fl_str_mv Yorca Ruiz, Ángel
Murillo García, Nancy
Magdaleno Herrero, Rebeca
Díaz Pons, Alexandre
Ortiz-García de la Foz, Víctor
Fernández Cacho, Luis Manuel
López Fanarraga, Mónica|||0000-0003-4754-311X
Ayesa Arriola, Rosa
author Yorca Ruiz, Ángel
author_facet Yorca Ruiz, Ángel
Murillo García, Nancy
Magdaleno Herrero, Rebeca
Díaz Pons, Alexandre
Ortiz-García de la Foz, Víctor
Fernández Cacho, Luis Manuel
López Fanarraga, Mónica|||0000-0003-4754-311X
Ayesa Arriola, Rosa
author_role author
author2 Murillo García, Nancy
Magdaleno Herrero, Rebeca
Díaz Pons, Alexandre
Ortiz-García de la Foz, Víctor
Fernández Cacho, Luis Manuel
López Fanarraga, Mónica|||0000-0003-4754-311X
Ayesa Arriola, Rosa
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv First-episode
First-degree relatives
Psychosis
Processing speed
Endophenotype
topic First-episode
First-degree relatives
Psychosis
Processing speed
Endophenotype
description Objective: The processing speed (PS) is highly impacted in individuals experiencing their first episode of psychosis (FEP). Conducting family studies can help to determine whether PS can serve as an endophenotype of schizophrenia spectrum disorders (SSDs), offering valuable insights into the prevention and diagnosis of SSDs. Method: A comprehensive cognitive battery, encompassing tests for PS, verbal memory, visual memory, working memory, executive functions, motor dexterity, and attention, was administered to a sample consisting of 133 FEP patients, 146 parents, 98 siblings, and 202 healthy controls (HCs). Univariate analyses (analysis of covariance [ANCOVA]) were conducted to compare the different cognitive domains between groups, utilizing sex, age, and years of education as covariates and Bonferroni corrections. Effect sizes (ESs) were calculated for estimating the magnitude of differences between groups. Results: Group comparisons revealed significant differences in all cognitive domains. PS was the most impaired function in patients. Parents and siblings had intermediate PS performance between FEP patients and HC. Large ES were observed in PS between FEP versus siblings, FEP versus controls, parents versus controls, and parents versus siblings. Conclusions: Despite not meeting all the necessary criteria, the PS observed in FEP patients and their first-degree relatives suggests its potential as a promising endophenotype of SSDs.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/34277
url https://hdl.handle.net/10902/34277
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Psychological Association
publisher.none.fl_str_mv American Psychological Association
dc.source.none.fl_str_mv Neuropsychology, 2024, 38(4), 357-367
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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