Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature

Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self‐limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short‐ and long‐term outcomes...

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Autores: Uribarri, Aitor, Núñez Gil, Iván Javier, Aritza Conty, D., Vedia, Óscar, Almendro Delia, Manuel, Durán Cambra, Albert, Martín García, Agustín C., Barrionuevo Sánchez, Marisa, Martínez Sellés Oliveria Soares, Manuel, RETAKO Investigators, Et al.
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/8855
Acceso en línea:http://hdl.handle.net/11268/8855
Access Level:acceso abierto
Palabra clave:Cardiología
Enfermedades
Tratamiento médico
Enfermedad cardiovascular
Medicina preventiva
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spelling Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical NatureUribarri, AitorNúñez Gil, Iván JavierAritza Conty, D.Vedia, ÓscarAlmendro Delia, ManuelDurán Cambra, AlbertMartín García, Agustín C.Barrionuevo Sánchez, MarisaMartínez Sellés Oliveria Soares, ManuelRETAKO InvestigatorsEt al.CardiologíaEnfermedadesTratamiento médicoEnfermedad cardiovascularMedicina preventivaTratamiento médicoBackground Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self‐limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short‐ and long‐term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short‐ and long‐term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction <30% and shock on admission, and increased long‐term mortality risk. Conclusions TTS triggered by physical factors could present a worse prognosis in terms of mortality. Under the TTS label, there could be as yet undiscovered very different clinical profiles, whose differentiation could lead to individual better management, and therefore the perception of TTS as having a benign prognosis should be generally ruled out.20202020-03-2620192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/8855reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/88552026-06-11T12:41:27Z
dc.title.none.fl_str_mv Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
title Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
spellingShingle Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
Uribarri, Aitor
Cardiología
Enfermedades
Tratamiento médico
Enfermedad cardiovascular
Medicina preventiva
Tratamiento médico
title_short Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
title_full Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
title_fullStr Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
title_full_unstemmed Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
title_sort Short‐ and Long‐Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature
dc.creator.none.fl_str_mv Uribarri, Aitor
Núñez Gil, Iván Javier
Aritza Conty, D.
Vedia, Óscar
Almendro Delia, Manuel
Durán Cambra, Albert
Martín García, Agustín C.
Barrionuevo Sánchez, Marisa
Martínez Sellés Oliveria Soares, Manuel
RETAKO Investigators
Et al.
author Uribarri, Aitor
author_facet Uribarri, Aitor
Núñez Gil, Iván Javier
Aritza Conty, D.
Vedia, Óscar
Almendro Delia, Manuel
Durán Cambra, Albert
Martín García, Agustín C.
Barrionuevo Sánchez, Marisa
Martínez Sellés Oliveria Soares, Manuel
RETAKO Investigators
Et al.
author_role author
author2 Núñez Gil, Iván Javier
Aritza Conty, D.
Vedia, Óscar
Almendro Delia, Manuel
Durán Cambra, Albert
Martín García, Agustín C.
Barrionuevo Sánchez, Marisa
Martínez Sellés Oliveria Soares, Manuel
RETAKO Investigators
Et al.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Cardiología
Enfermedades
Tratamiento médico
Enfermedad cardiovascular
Medicina preventiva
Tratamiento médico
topic Cardiología
Enfermedades
Tratamiento médico
Enfermedad cardiovascular
Medicina preventiva
Tratamiento médico
description Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self‐limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short‐ and long‐term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short‐ and long‐term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction <30% and shock on admission, and increased long‐term mortality risk. Conclusions TTS triggered by physical factors could present a worse prognosis in terms of mortality. Under the TTS label, there could be as yet undiscovered very different clinical profiles, whose differentiation could lead to individual better management, and therefore the perception of TTS as having a benign prognosis should be generally ruled out.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
2020
2020-03-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/8855
url http://hdl.handle.net/11268/8855
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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