Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures

An elusive phenomenon in network neuroscience is the extent of neuronal activity remodeling upon damage. Here, we investigate the action of gradual synaptic blockade on the effective connectivity in cortical networks in vitro. We use two neuronal cultures configurations one formed by about 130 neuro...

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Detalles Bibliográficos
Autores: Estévez Priego, Estefanía, Teller Amado, Sara, Granell, Clara, Arenas, Àlex, Soriano i Fradera, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/179459
Acceso en línea:https://hdl.handle.net/2445/179459
Access Level:acceso abierto
Palabra clave:Sinapsi
Neurotransmissió
Synapses
Neural transmission
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spelling Functional strengthening through synaptic scaling upon connectivity disruption in neuronal culturesEstévez Priego, EstefaníaTeller Amado, SaraGranell, ClaraArenas, ÀlexSoriano i Fradera, JordiSinapsiNeurotransmissióSynapsesNeural transmissionAn elusive phenomenon in network neuroscience is the extent of neuronal activity remodeling upon damage. Here, we investigate the action of gradual synaptic blockade on the effective connectivity in cortical networks in vitro. We use two neuronal cultures configurations one formed by about 130 neuronal aggregates and another one formed by about 600 individual neurons and monitor their spontaneous activity upon progressive weakening of excitatory connectivity. We report that the effective connectivity in all cultures exhibits a first phase of transient strengthening followed by a second phase of steady deterioration. We quantify these phases by measuring GEFF, the global efficiency in processing network information. We term hyperefficiency the sudden strengthening of GEFF upon network deterioration, which increases by 20-50% depending on culture type. Relying on numerical simulations we reveal the role of synaptic scaling, an activity-dependent mechanism for synaptic plasticity, in counteracting the perturbative action, neatly reproducing the observed hyperefficiency. Our results demonstrate the importance of synaptic scaling as resilience mechanism.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/179459Articles publicats en revistes (Física de la Matèria Condensada)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1162/netn_a_00156Network Neuroscience, 2020, vol. 4, num. 4, p. 1160-1180https://doi.org/10.1162/netn_a_00156info:eu-repo/grantAgreement/EC/H2020/713140cc by (c) Massachusetts Institute of Technology, 2020https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1794592026-05-27T06:46:51Z
dc.title.none.fl_str_mv Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
title Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
spellingShingle Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
Estévez Priego, Estefanía
Sinapsi
Neurotransmissió
Synapses
Neural transmission
title_short Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
title_full Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
title_fullStr Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
title_full_unstemmed Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
title_sort Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures
dc.creator.none.fl_str_mv Estévez Priego, Estefanía
Teller Amado, Sara
Granell, Clara
Arenas, Àlex
Soriano i Fradera, Jordi
author Estévez Priego, Estefanía
author_facet Estévez Priego, Estefanía
Teller Amado, Sara
Granell, Clara
Arenas, Àlex
Soriano i Fradera, Jordi
author_role author
author2 Teller Amado, Sara
Granell, Clara
Arenas, Àlex
Soriano i Fradera, Jordi
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sinapsi
Neurotransmissió
Synapses
Neural transmission
topic Sinapsi
Neurotransmissió
Synapses
Neural transmission
description An elusive phenomenon in network neuroscience is the extent of neuronal activity remodeling upon damage. Here, we investigate the action of gradual synaptic blockade on the effective connectivity in cortical networks in vitro. We use two neuronal cultures configurations one formed by about 130 neuronal aggregates and another one formed by about 600 individual neurons and monitor their spontaneous activity upon progressive weakening of excitatory connectivity. We report that the effective connectivity in all cultures exhibits a first phase of transient strengthening followed by a second phase of steady deterioration. We quantify these phases by measuring GEFF, the global efficiency in processing network information. We term hyperefficiency the sudden strengthening of GEFF upon network deterioration, which increases by 20-50% depending on culture type. Relying on numerical simulations we reveal the role of synaptic scaling, an activity-dependent mechanism for synaptic plasticity, in counteracting the perturbative action, neatly reproducing the observed hyperefficiency. Our results demonstrate the importance of synaptic scaling as resilience mechanism.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179459
url https://hdl.handle.net/2445/179459
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1162/netn_a_00156
Network Neuroscience, 2020, vol. 4, num. 4, p. 1160-1180
https://doi.org/10.1162/netn_a_00156
info:eu-repo/grantAgreement/EC/H2020/713140
dc.rights.none.fl_str_mv cc by (c) Massachusetts Institute of Technology, 2020
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Massachusetts Institute of Technology, 2020
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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