Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers

Humans are exposed daily to contaminants such as organophosphorus flame retardants (PFRs), legacy plasticizers (LPs), and alternative plasticizers (APs). To date, most biomonitoring studies in children have only focused on analysis of LP metabolites and a subset of PFRs and APs. This study investiga...

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Autores: Proost, Sebastian, Vich Vila, Arnau, Raes, Jeroen, Vanhaecke, Lynn, De Boevre, Marthe, De Saeger, Sarah, Nawrot, Tim S., Poma, Giulia, Covaci, Adrian, Ouden, Fatima den, Cseresznye, Adam, Engelen, Liesa, Maris, Elias, Bosschaerts, Stijn, Gys, Celine, Cleys, Paulien, Ait Bamai, Yu, Peró Gascón, Roger, Hemeryck, Lieselot Y., Paepe, Ellen De
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2026
País:España
Recursos:Universidad de Oviedo (UNIOVI)
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/225648
Acesso em linha:https://hdl.handle.net/2445/225648
Access Level:acceso embargado
Palavra-chave:Plastificants
Retardants de flama
Avaluació del risc
Plasticizers
Fireproofing agents
Risk assessment
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spelling Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizersProost, SebastianVich Vila, ArnauRaes, JeroenVanhaecke, LynnDe Boevre, MartheDe Saeger, SarahNawrot, Tim S.Poma, GiuliaCovaci, AdrianOuden, Fatima denCseresznye, AdamEngelen, LiesaMaris, EliasBosschaerts, StijnGys, CelineCleys, PaulienAit Bamai, YuPeró Gascón, RogerHemeryck, Lieselot Y.Paepe, Ellen DePlastificantsRetardants de flamaAvaluació del riscPlasticizersFireproofing agentsRisk assessmentHumans are exposed daily to contaminants such as organophosphorus flame retardants (PFRs), legacy plasticizers (LPs), and alternative plasticizers (APs). To date, most biomonitoring studies in children have only focused on analysis of LP metabolites and a subset of PFRs and APs. This study investigated exposure to multiple PFRs, LPs and APs in the ENVIR<em>ON</em>AGE birth cohort quantifying 13 PFR metabolites in 655 urine samples, while we measured 8 LP and 13 AP metabolites in urine of 328 children. For PFRs, more than 50% of children were exposed to TNBP, TPHP, TDCIPP, TCIPP and EHDPHP. More than 93% of children were exposed to the measured LPs (DEP, DiBP, DnBP, BBzP and DEHP), while for APs more than 50% of children showed exposure to DEHA, DEHTP, DINCH and DIDP. Concentrations of PFR metabolites were higher in summer, while the presence of a pet in the house was associated with higher LP metabolite concentrations. Risk characterization ratios (RCRs) for single compounds and hazard indices (HIs) for compound classes suggested no risk for adverse health effects due to PFR exposure. For LPs, two children showed a HI above 1, while for APs, ten children had a HI above 1. The results indicate widespread exposure to PFRs and plasticizers, with most children being exposed to levels that are considered safe. However, the current study confirms a shift in exposure from LPs to APs, implying the need for further research on exposure to multiple APs in future studies.Elsevier2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/225648Articles publicats en revistes (Enginyeria Química i Química Analítica)reponame:Dipòsit Digital de la UBinstname:Universidad de Oviedo (UNIOVI)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.envres.2025.123275Environmental Research, 2026, vol. 288https://doi.org/10.1016/j.envres.2025.123275cc-by-nc-nd (c) Academic Press, 2026http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:diposit.ub.edu:2445/2256482026-05-27T06:46:51Z
dc.title.none.fl_str_mv Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
title Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
spellingShingle Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
Proost, Sebastian
Plastificants
Retardants de flama
Avaluació del risc
Plasticizers
Fireproofing agents
Risk assessment
title_short Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
title_full Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
title_fullStr Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
title_full_unstemmed Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
title_sort Chemical exposure in childhood: A. study on organophosphate flame retardants and plasticizers
dc.creator.none.fl_str_mv Proost, Sebastian
Vich Vila, Arnau
Raes, Jeroen
Vanhaecke, Lynn
De Boevre, Marthe
De Saeger, Sarah
Nawrot, Tim S.
Poma, Giulia
Covaci, Adrian
Ouden, Fatima den
Cseresznye, Adam
Engelen, Liesa
Maris, Elias
Bosschaerts, Stijn
Gys, Celine
Cleys, Paulien
Ait Bamai, Yu
Peró Gascón, Roger
Hemeryck, Lieselot Y.
Paepe, Ellen De
author Proost, Sebastian
author_facet Proost, Sebastian
Vich Vila, Arnau
Raes, Jeroen
Vanhaecke, Lynn
De Boevre, Marthe
De Saeger, Sarah
Nawrot, Tim S.
Poma, Giulia
Covaci, Adrian
Ouden, Fatima den
Cseresznye, Adam
Engelen, Liesa
Maris, Elias
Bosschaerts, Stijn
Gys, Celine
Cleys, Paulien
Ait Bamai, Yu
Peró Gascón, Roger
Hemeryck, Lieselot Y.
Paepe, Ellen De
author_role author
author2 Vich Vila, Arnau
Raes, Jeroen
Vanhaecke, Lynn
De Boevre, Marthe
De Saeger, Sarah
Nawrot, Tim S.
Poma, Giulia
Covaci, Adrian
Ouden, Fatima den
Cseresznye, Adam
Engelen, Liesa
Maris, Elias
Bosschaerts, Stijn
Gys, Celine
Cleys, Paulien
Ait Bamai, Yu
Peró Gascón, Roger
Hemeryck, Lieselot Y.
Paepe, Ellen De
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Plastificants
Retardants de flama
Avaluació del risc
Plasticizers
Fireproofing agents
Risk assessment
topic Plastificants
Retardants de flama
Avaluació del risc
Plasticizers
Fireproofing agents
Risk assessment
description Humans are exposed daily to contaminants such as organophosphorus flame retardants (PFRs), legacy plasticizers (LPs), and alternative plasticizers (APs). To date, most biomonitoring studies in children have only focused on analysis of LP metabolites and a subset of PFRs and APs. This study investigated exposure to multiple PFRs, LPs and APs in the ENVIR<em>ON</em>AGE birth cohort quantifying 13 PFR metabolites in 655 urine samples, while we measured 8 LP and 13 AP metabolites in urine of 328 children. For PFRs, more than 50% of children were exposed to TNBP, TPHP, TDCIPP, TCIPP and EHDPHP. More than 93% of children were exposed to the measured LPs (DEP, DiBP, DnBP, BBzP and DEHP), while for APs more than 50% of children showed exposure to DEHA, DEHTP, DINCH and DIDP. Concentrations of PFR metabolites were higher in summer, while the presence of a pet in the house was associated with higher LP metabolite concentrations. Risk characterization ratios (RCRs) for single compounds and hazard indices (HIs) for compound classes suggested no risk for adverse health effects due to PFR exposure. For LPs, two children showed a HI above 1, while for APs, ten children had a HI above 1. The results indicate widespread exposure to PFRs and plasticizers, with most children being exposed to levels that are considered safe. However, the current study confirms a shift in exposure from LPs to APs, implying the need for further research on exposure to multiple APs in future studies.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/225648
url https://hdl.handle.net/2445/225648
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.envres.2025.123275
Environmental Research, 2026, vol. 288
https://doi.org/10.1016/j.envres.2025.123275
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Academic Press, 2026
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv cc-by-nc-nd (c) Academic Press, 2026
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Química i Química Analítica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Oviedo (UNIOVI)
instname_str Universidad de Oviedo (UNIOVI)
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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