Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia

The aim of this study was to evaluate the diagnostic performance of plasma Lipocalin-2 (LCN2) concentration in adult patients with community-acquired pneumonia (CAP) to determine its etiology, severity and prognosis. A prospective observational study involving adults with CAP from November 2015 to M...

ver descrição completa

Detalhes bibliográficos
Autores: Boix Palop, Lucía, Vergara, Andrea, Padilla, Emma, Martínez, Diego, Blanco, Ana, Pérez, Josefa, Calbo, Esther, Vila, Jordi, Casals-Pascual, Climent
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3734
Acesso em linha:http://hdl.handle.net/20.500.12328/3734
https://dx.doi.org/10.3390/microorganisms11051160
Access Level:acceso abierto
Palavra-chave:Lipocalina-2
Gravetat
Biomarcador
Pneumònia pneumocòcica
Gravedad
Neumonía neumocócica
Lipocalin-2
Severity
Biomarker
Pneumococcal pneumonia
61
id ES_dff34e1f714cc3879880d793c1bf98ef
oai_identifier_str oai:recercat.cat:20.500.12328/3734
network_acronym_str ES
network_name_str España
repository_id_str
spelling Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumoniaBoix Palop, LucíaVergara, AndreaPadilla, EmmaMartínez, DiegoBlanco, AnaPérez, JosefaCalbo, EstherVila, JordiCasals-Pascual, ClimentLipocalina-2GravetatBiomarcadorPneumònia pneumocòcicaLipocalina-2GravedadBiomarcadorNeumonía neumocócicaLipocalin-2SeverityBiomarkerPneumococcal pneumonia61The aim of this study was to evaluate the diagnostic performance of plasma Lipocalin-2 (LCN2) concentration in adult patients with community-acquired pneumonia (CAP) to determine its etiology, severity and prognosis. A prospective observational study involving adults with CAP from November 2015 to May 2017 was conducted. Plasma LCN2 concentration was measured upon admission by a modified enzyme immunoassay coupled with chemiluminescence (Architect, Abbott Laboratories). The diagnostic performance of LCN2, C-reactive protein (CRP) and white blood cell to predict bacterial CAP was assessed. A total of 130 patients with CAP were included: 71 (54.6%) bacterial CAP, 42 (32.3%) unknown origin CAP and 17 (13.1%) viral CAP. LCN2 was higher in bacterial CAP than in non-bacterial CAP (122.0 vs. 89.7 ng/mL, respectively) (p = 0.03) with a limited ability to distinguish bacterial and non-bacterial CAP (AUROC: 0.62 [95% CI 0.52–0.72]). The LCN2 cutoff ≥ 204 ng/mL predicted the presence of pneumococcal bacteremia with an AUROC of 0.74 (sensitivity 70%, specificity 79.1%). Regarding severity, as defined by CURB-65 and PSI scores, there was a significant linear trend in the mean concentration of LCN2, exhibiting a shift from the low-risk to the intermediate-risk and high-risk group (p < 0.001 and 0.001, respectively). LCN2 concentration was associated with severity in adult patients with CAP. However, its utility as a biomarker to discriminate viral and bacterial etiology in CAP is limited.info:eu-repo/semantics/publishedVersionMDPI2023info:eu-repo/semantics/article12http://hdl.handle.net/20.500.12328/3734https://dx.doi.org/10.3390/microorganisms11051160reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMicroorganisms11https://www.mdpi.com/2076-2607/11/5/1160© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/37342026-05-29T05:05:01Z
dc.title.none.fl_str_mv Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
title Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
spellingShingle Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
Boix Palop, Lucía
Lipocalina-2
Gravetat
Biomarcador
Pneumònia pneumocòcica
Lipocalina-2
Gravedad
Biomarcador
Neumonía neumocócica
Lipocalin-2
Severity
Biomarker
Pneumococcal pneumonia
61
title_short Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
title_full Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
title_fullStr Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
title_full_unstemmed Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
title_sort Evaluation of plasma lipocalin-2 as a predictor of etiology and severity in adult patients with community-acquired pneumonia
dc.creator.none.fl_str_mv Boix Palop, Lucía
Vergara, Andrea
Padilla, Emma
Martínez, Diego
Blanco, Ana
Pérez, Josefa
Calbo, Esther
Vila, Jordi
Casals-Pascual, Climent
author Boix Palop, Lucía
author_facet Boix Palop, Lucía
Vergara, Andrea
Padilla, Emma
Martínez, Diego
Blanco, Ana
Pérez, Josefa
Calbo, Esther
Vila, Jordi
Casals-Pascual, Climent
author_role author
author2 Vergara, Andrea
Padilla, Emma
Martínez, Diego
Blanco, Ana
Pérez, Josefa
Calbo, Esther
Vila, Jordi
Casals-Pascual, Climent
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lipocalina-2
Gravetat
Biomarcador
Pneumònia pneumocòcica
Lipocalina-2
Gravedad
Biomarcador
Neumonía neumocócica
Lipocalin-2
Severity
Biomarker
Pneumococcal pneumonia
61
topic Lipocalina-2
Gravetat
Biomarcador
Pneumònia pneumocòcica
Lipocalina-2
Gravedad
Biomarcador
Neumonía neumocócica
Lipocalin-2
Severity
Biomarker
Pneumococcal pneumonia
61
description The aim of this study was to evaluate the diagnostic performance of plasma Lipocalin-2 (LCN2) concentration in adult patients with community-acquired pneumonia (CAP) to determine its etiology, severity and prognosis. A prospective observational study involving adults with CAP from November 2015 to May 2017 was conducted. Plasma LCN2 concentration was measured upon admission by a modified enzyme immunoassay coupled with chemiluminescence (Architect, Abbott Laboratories). The diagnostic performance of LCN2, C-reactive protein (CRP) and white blood cell to predict bacterial CAP was assessed. A total of 130 patients with CAP were included: 71 (54.6%) bacterial CAP, 42 (32.3%) unknown origin CAP and 17 (13.1%) viral CAP. LCN2 was higher in bacterial CAP than in non-bacterial CAP (122.0 vs. 89.7 ng/mL, respectively) (p = 0.03) with a limited ability to distinguish bacterial and non-bacterial CAP (AUROC: 0.62 [95% CI 0.52–0.72]). The LCN2 cutoff ≥ 204 ng/mL predicted the presence of pneumococcal bacteremia with an AUROC of 0.74 (sensitivity 70%, specificity 79.1%). Regarding severity, as defined by CURB-65 and PSI scores, there was a significant linear trend in the mean concentration of LCN2, exhibiting a shift from the low-risk to the intermediate-risk and high-risk group (p < 0.001 and 0.001, respectively). LCN2 concentration was associated with severity in adult patients with CAP. However, its utility as a biomarker to discriminate viral and bacterial etiology in CAP is limited.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3734
https://dx.doi.org/10.3390/microorganisms11051160
url http://hdl.handle.net/20.500.12328/3734
https://dx.doi.org/10.3390/microorganisms11051160
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Microorganisms
11
https://www.mdpi.com/2076-2607/11/5/1160
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422110116413440
score 15,812429

Registos relacionados