Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis

Background/Objectives: Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic path...

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Autores: Diaz-Ruiz, R, Poca, M, Roman, E, Panadero-Gomez, R, Cuyàs, B, Bañares, I, Morales, A, Puerto, M, Lopez-Esteban, R, Blazquez, E, Fernández-Castillo, M, Correa-Rocha, R, Rapado-Castro, M, Breton, I, Bañares, R, Soriano, G, Garcia-Martinez, R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19149
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19149
Access Level:acceso abierto
Palabra clave:vitamin D
cognitive function
liver cirrhosis
inflammation
human
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spelling Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with CirrhosisDiaz-Ruiz, RPoca, MRoman, EPanadero-Gomez, RCuyàs, BBañares, IMorales, APuerto, MLopez-Esteban, RBlazquez, EFernández-Castillo, MCorrea-Rocha, RRapado-Castro, MBreton, IBañares, RSoriano, GGarcia-Martinez, Rvitamin Dcognitive functionliver cirrhosisinflammationhumanBackground/Objectives: Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic pathogenic role. Extraskeletal functions of vitamin D include immunomodulation, and its deficiency has been implicated in immune dysfunction and different forms of cognitive impairment. The aim was to assess changes in cognitive function and inflammation in decompensated patients with cirrhosis receiving vitamin D supplementation. Methods: Patients with cirrhosis discharged from decompensation in two tertiary hospitals in Spain (from September 2017 to January 2020) were assessed before, at 6 and 12 months after vitamin D supplementation. A comprehensive neuropsychological battery and neuroinflammatory markers were examined. In a subgroup of patients, peripheral immune blood cells were analyzed. Results: Thirty-nine patients were recruited. Of those, 27 completed the 6 months evaluation and were analyzed [age 62.4 +/- 11.3 years; 22 men; Model for End-Stage Liver Disease (MELD) 11.7 +/- 4.0; prior overt HE 33%; median 25-hydroxyvitamin D (25OHD) plasma level 12.7 mu gr/L] and 22 achieved 12 months assessment. At baseline, learning and memory (R = 0.382; p = 0.049) and working memory (R = 0.503; p = 0.047) subtests correlated with plasma 25OHD levels. In addition, processing speed (R = -0.42; p = 0.04), attention (R = -0.48; p = 0.04), Tinnetti balance (R = -0.656; p < 0.001) and Tinnetti score (R = -0.659; p < 0.001) were linked to neuroinflammation marker IL-1 beta. Patients with lower 25OHD had a greater proportion of TH1cells at baseline and a larger amelioration of IL-1 beta and IL-6 following supplementation. An improvement in working memory was found after 25OHD replacement (46.7 +/- 13 to 50 +/- 11; p = 0.047). Conclusions: This study supports that vitamin D supplementation modulates low-grade inflammation in decompensated cirrhosis providing cognitive benefits, particularly in working memory.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19149NutrientsISSN: 20726643reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p191492026-06-14T12:41:47Z
dc.title.none.fl_str_mv Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
title Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
spellingShingle Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
Diaz-Ruiz, R
vitamin D
cognitive function
liver cirrhosis
inflammation
human
title_short Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
title_full Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
title_fullStr Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
title_full_unstemmed Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
title_sort Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis
dc.creator.none.fl_str_mv Diaz-Ruiz, R
Poca, M
Roman, E
Panadero-Gomez, R
Cuyàs, B
Bañares, I
Morales, A
Puerto, M
Lopez-Esteban, R
Blazquez, E
Fernández-Castillo, M
Correa-Rocha, R
Rapado-Castro, M
Breton, I
Bañares, R
Soriano, G
Garcia-Martinez, R
author Diaz-Ruiz, R
author_facet Diaz-Ruiz, R
Poca, M
Roman, E
Panadero-Gomez, R
Cuyàs, B
Bañares, I
Morales, A
Puerto, M
Lopez-Esteban, R
Blazquez, E
Fernández-Castillo, M
Correa-Rocha, R
Rapado-Castro, M
Breton, I
Bañares, R
Soriano, G
Garcia-Martinez, R
author_role author
author2 Poca, M
Roman, E
Panadero-Gomez, R
Cuyàs, B
Bañares, I
Morales, A
Puerto, M
Lopez-Esteban, R
Blazquez, E
Fernández-Castillo, M
Correa-Rocha, R
Rapado-Castro, M
Breton, I
Bañares, R
Soriano, G
Garcia-Martinez, R
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv vitamin D
cognitive function
liver cirrhosis
inflammation
human
topic vitamin D
cognitive function
liver cirrhosis
inflammation
human
description Background/Objectives: Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic pathogenic role. Extraskeletal functions of vitamin D include immunomodulation, and its deficiency has been implicated in immune dysfunction and different forms of cognitive impairment. The aim was to assess changes in cognitive function and inflammation in decompensated patients with cirrhosis receiving vitamin D supplementation. Methods: Patients with cirrhosis discharged from decompensation in two tertiary hospitals in Spain (from September 2017 to January 2020) were assessed before, at 6 and 12 months after vitamin D supplementation. A comprehensive neuropsychological battery and neuroinflammatory markers were examined. In a subgroup of patients, peripheral immune blood cells were analyzed. Results: Thirty-nine patients were recruited. Of those, 27 completed the 6 months evaluation and were analyzed [age 62.4 +/- 11.3 years; 22 men; Model for End-Stage Liver Disease (MELD) 11.7 +/- 4.0; prior overt HE 33%; median 25-hydroxyvitamin D (25OHD) plasma level 12.7 mu gr/L] and 22 achieved 12 months assessment. At baseline, learning and memory (R = 0.382; p = 0.049) and working memory (R = 0.503; p = 0.047) subtests correlated with plasma 25OHD levels. In addition, processing speed (R = -0.42; p = 0.04), attention (R = -0.48; p = 0.04), Tinnetti balance (R = -0.656; p < 0.001) and Tinnetti score (R = -0.659; p < 0.001) were linked to neuroinflammation marker IL-1 beta. Patients with lower 25OHD had a greater proportion of TH1cells at baseline and a larger amelioration of IL-1 beta and IL-6 following supplementation. An improvement in working memory was found after 25OHD replacement (46.7 +/- 13 to 50 +/- 11; p = 0.047). Conclusions: This study supports that vitamin D supplementation modulates low-grade inflammation in decompensated cirrhosis providing cognitive benefits, particularly in working memory.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19149
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19149
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nutrients
ISSN: 20726643
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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