Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country

Background: Chagas disease (CD) is a chronic parasitic disease caused by Trypanosoma cruzi and is endemic to continental Latin America. In Spain, the main transmission route is congenital. We aimed to assess adherence to regional recommendations of universal screening for CD during pregnancy in Lati...

Descripción completa

Detalles Bibliográficos
Autores: Llenas-García, Jara, Wikman-Jorgensen, Philip, Gil-Anguita, Concepción, Ramos- Sesma, Violeta, Torrus-Tendero, Diego, Martínez Goñi, Raquel, Romero-Nieto, Mónica, García-Abellán, Javier, Esteban-Giner, María José, Antelo, Karenina, Navarro-Cots, María, Buñuel, Fernando, Amador, Concepción, García García, Josefa, Gascón, Isabel, Ramos Rincón, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/39434
Acceso en línea:https://hdl.handle.net/11000/39434
Access Level:acceso abierto
Palabra clave:Chagas disease
Screening
Pregnant women
id ES_dfdcf3368239e19cb0e15660ad4ec51e
oai_identifier_str oai:dspace.umh.es:11000/39434
network_acronym_str ES
network_name_str España
repository_id_str
spelling Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic countryLlenas-García, JaraWikman-Jorgensen, PhilipGil-Anguita, ConcepciónRamos- Sesma, VioletaTorrus-Tendero, DiegoMartínez Goñi, RaquelRomero-Nieto, MónicaGarcía-Abellán, JavierEsteban-Giner, María JoséAntelo, KareninaNavarro-Cots, MaríaBuñuel, FernandoAmador, ConcepciónGarcía García, JosefaGascón, IsabelRamos Rincón, José ManuelChagas diseaseScreeningPregnant womenBackground: Chagas disease (CD) is a chronic parasitic disease caused by Trypanosoma cruzi and is endemic to continental Latin America. In Spain, the main transmission route is congenital. We aimed to assess adherence to regional recommendations of universal screening for CD during pregnancy in Latin American women in the province of Alicante from 2014 to 2018. Methodology/principal findings: Retrospective quality study using two data sources: 1) delivery records of Latin American women that gave birth in the 10 public hospitals of Alicante between January 2014 and December 2018; and 2) records of Chagas serologies carried out in those centers between May 2013 and December 2018. There were 3026 deliveries in Latin American women during the study period; 1178 (38.9%) underwent CD serology. Screening adherence ranged from 17.2% to 59.3% in the different health departments and was higher in Bolivian women (48.3%). Twenty-six deliveries (2.2%) had a positive screening; CD was confirmed in 23 (2%) deliveries of 21 women. Bolivians had the highest seroprevalence (21/112; 18.7%), followed by Colombians (1/333; 0.3%) and Ecuadorians (1/348; 0.3%). Of 21 CD-positive women (19 Bolivians, 1 Colombian, 1 Ecuadorian), infection was already known in 12 (57.1%), and 9 (42.9%) had already been treated. Only 1 of the 12 untreated women (8.3%) was treated postpartum. Follow-up started in 20 of the 23 (87.0%) neonates but was completed only in 11 (47.8%); no cases of congenital transmission were detected. Among the 1848 unscreened deliveries, we estimate 43 undiagnosed cases of CD and 1 to 2 undetected cases of congenital transmission. Conclusions/significance: Adherence to recommendations of systematic screening for CD in Latin American pregnant women in Alicante can be improved. Strategies to strengthen treatment of postpartum women and monitoring of exposed newborns are needed. Currently, there may be undetected cases of congenital transmission in our province.PLOSDepartamentos de la UMH::Medicina Clínica202620262021info:eu-repo/semantics/articleapplication/pdf14application/pdfhttps://hdl.handle.net/11000/39434reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.1371/journal.pntd.0009281info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/394342026-05-27T13:36:21Z
dc.title.none.fl_str_mv Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
title Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
spellingShingle Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
Llenas-García, Jara
Chagas disease
Screening
Pregnant women
title_short Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
title_full Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
title_fullStr Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
title_full_unstemmed Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
title_sort Chagas disease screening in pregnant Latin American women: Adherence to a systematic screening protocol in a non-endemic country
dc.creator.none.fl_str_mv Llenas-García, Jara
Wikman-Jorgensen, Philip
Gil-Anguita, Concepción
Ramos- Sesma, Violeta
Torrus-Tendero, Diego
Martínez Goñi, Raquel
Romero-Nieto, Mónica
García-Abellán, Javier
Esteban-Giner, María José
Antelo, Karenina
Navarro-Cots, María
Buñuel, Fernando
Amador, Concepción
García García, Josefa
Gascón, Isabel
Ramos Rincón, José Manuel
author Llenas-García, Jara
author_facet Llenas-García, Jara
Wikman-Jorgensen, Philip
Gil-Anguita, Concepción
Ramos- Sesma, Violeta
Torrus-Tendero, Diego
Martínez Goñi, Raquel
Romero-Nieto, Mónica
García-Abellán, Javier
Esteban-Giner, María José
Antelo, Karenina
Navarro-Cots, María
Buñuel, Fernando
Amador, Concepción
García García, Josefa
Gascón, Isabel
Ramos Rincón, José Manuel
author_role author
author2 Wikman-Jorgensen, Philip
Gil-Anguita, Concepción
Ramos- Sesma, Violeta
Torrus-Tendero, Diego
Martínez Goñi, Raquel
Romero-Nieto, Mónica
García-Abellán, Javier
Esteban-Giner, María José
Antelo, Karenina
Navarro-Cots, María
Buñuel, Fernando
Amador, Concepción
García García, Josefa
Gascón, Isabel
Ramos Rincón, José Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Medicina Clínica
dc.subject.none.fl_str_mv Chagas disease
Screening
Pregnant women
topic Chagas disease
Screening
Pregnant women
description Background: Chagas disease (CD) is a chronic parasitic disease caused by Trypanosoma cruzi and is endemic to continental Latin America. In Spain, the main transmission route is congenital. We aimed to assess adherence to regional recommendations of universal screening for CD during pregnancy in Latin American women in the province of Alicante from 2014 to 2018. Methodology/principal findings: Retrospective quality study using two data sources: 1) delivery records of Latin American women that gave birth in the 10 public hospitals of Alicante between January 2014 and December 2018; and 2) records of Chagas serologies carried out in those centers between May 2013 and December 2018. There were 3026 deliveries in Latin American women during the study period; 1178 (38.9%) underwent CD serology. Screening adherence ranged from 17.2% to 59.3% in the different health departments and was higher in Bolivian women (48.3%). Twenty-six deliveries (2.2%) had a positive screening; CD was confirmed in 23 (2%) deliveries of 21 women. Bolivians had the highest seroprevalence (21/112; 18.7%), followed by Colombians (1/333; 0.3%) and Ecuadorians (1/348; 0.3%). Of 21 CD-positive women (19 Bolivians, 1 Colombian, 1 Ecuadorian), infection was already known in 12 (57.1%), and 9 (42.9%) had already been treated. Only 1 of the 12 untreated women (8.3%) was treated postpartum. Follow-up started in 20 of the 23 (87.0%) neonates but was completed only in 11 (47.8%); no cases of congenital transmission were detected. Among the 1848 unscreened deliveries, we estimate 43 undiagnosed cases of CD and 1 to 2 undetected cases of congenital transmission. Conclusions/significance: Adherence to recommendations of systematic screening for CD in Latin American pregnant women in Alicante can be improved. Strategies to strengthen treatment of postpartum women and monitoring of exposed newborns are needed. Currently, there may be undetected cases of congenital transmission in our province.
publishDate 2021
dc.date.none.fl_str_mv 2021
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/39434
url https://hdl.handle.net/11000/39434
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.1371/journal.pntd.0009281
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
14
application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422102568763392
score 15,81155

Similares en LA Referencia