Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium
Background: Sweeteners and sweetness enhancers (S&SE) are used to replace energy yielding sugars and maintain sweet taste in a wide range of products, but controversy exists about their effects on appetite and endocrine responses in reduced or no added sugar solid foods. The aim of the current s...
| Autores: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/69952 |
| Acesso em linha: | https://hdl.handle.net/10171/69952 |
| Access Level: | acceso abierto |
| Palavra-chave: | Sweeteners Endocrine response Sweetness enhancers Solid food Appetite Glycaemia |
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Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium |
| title |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium |
| spellingShingle |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium Gibbons, C. (Catherine)|||/items/428f7d30-bd11-48fc-ba3b-84f5007ee034 Sweeteners Endocrine response Sweetness enhancers Solid food Appetite Glycaemia |
| title_short |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium |
| title_full |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium |
| title_fullStr |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium |
| title_full_unstemmed |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium |
| title_sort |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortium |
| dc.creator.none.fl_str_mv |
Gibbons, C. (Catherine)|||/items/428f7d30-bd11-48fc-ba3b-84f5007ee034 Beaulieu, K. (Kristine)|||/items/22f79b69-93f7-42a6-8695-0c0e689a8725 Almirón-Roig, E. (Eva)|||/items/b81f0e28-3e49-4ac8-ba49-636f956e5315 Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e O'Hara, B. (Beverly)|||/items/921b476c-bfb5-4870-9eec-0dcc6b7ee91c O'Connor, D. (Dominic)|||/items/9936a48f-7a0e-4da4-98ce-5e0d3ad02291 Nazare, J.A. (Julie-Anne)|||/items/a06ca456-81fa-418f-84c4-6a6b976beedb Le Bail, A. (Alain)|||/items/d89abcdf-8d0d-4460-888b-6217bd0bd004 Rannou, C. (Cécile)|||/items/d47a39c1-a444-4413-8636-23a46ef21418 Hardman, C.H. (Charlotte A.)|||/items/48e7a6e8-0daa-4180-ac0c-b6ece0067bf7 Wilton, M. (Moon)|||/items/2711f000-b9a3-42c3-9083-39c2d498ee83 Kjølbæk, L. (Louise)|||/items/c55e8f75-5375-4429-a5d7-f6bea0a23978 Scott, C. (Corey)|||/items/8b255b42-a80e-4c42-bcb7-8dd5ff85c464 Moshoyiannis, H. (Hariklia)|||/items/f4c72a3f-d917-4bf0-8d1b-1a9e09cc57bf Raben, A. (Anne)|||/items/a0dd7aa4-c4fc-4661-8066-d76c26173901 Harrold, J.A. (Joanne A.)|||/items/eb3f9e48-c22b-44ff-9065-982a8a64cd8f Halford, J.C.G. (Jason C. G.)|||/items/b7b4e39e-b449-4951-8ffa-2a5645bf880c Finlayson, G. (Graham)|||/items/7c6bfe3b-7403-4ad2-8fc7-178aef24f593 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author |
Gibbons, C. (Catherine)|||/items/428f7d30-bd11-48fc-ba3b-84f5007ee034 |
| author_facet |
Gibbons, C. (Catherine)|||/items/428f7d30-bd11-48fc-ba3b-84f5007ee034 Beaulieu, K. (Kristine)|||/items/22f79b69-93f7-42a6-8695-0c0e689a8725 Almirón-Roig, E. (Eva)|||/items/b81f0e28-3e49-4ac8-ba49-636f956e5315 Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e O'Hara, B. (Beverly)|||/items/921b476c-bfb5-4870-9eec-0dcc6b7ee91c O'Connor, D. (Dominic)|||/items/9936a48f-7a0e-4da4-98ce-5e0d3ad02291 Nazare, J.A. (Julie-Anne)|||/items/a06ca456-81fa-418f-84c4-6a6b976beedb Le Bail, A. (Alain)|||/items/d89abcdf-8d0d-4460-888b-6217bd0bd004 Rannou, C. (Cécile)|||/items/d47a39c1-a444-4413-8636-23a46ef21418 Hardman, C.H. (Charlotte A.)|||/items/48e7a6e8-0daa-4180-ac0c-b6ece0067bf7 Wilton, M. (Moon)|||/items/2711f000-b9a3-42c3-9083-39c2d498ee83 Kjølbæk, L. (Louise)|||/items/c55e8f75-5375-4429-a5d7-f6bea0a23978 Scott, C. (Corey)|||/items/8b255b42-a80e-4c42-bcb7-8dd5ff85c464 Moshoyiannis, H. (Hariklia)|||/items/f4c72a3f-d917-4bf0-8d1b-1a9e09cc57bf Raben, A. (Anne)|||/items/a0dd7aa4-c4fc-4661-8066-d76c26173901 Harrold, J.A. (Joanne A.)|||/items/eb3f9e48-c22b-44ff-9065-982a8a64cd8f Halford, J.C.G. (Jason C. G.)|||/items/b7b4e39e-b449-4951-8ffa-2a5645bf880c Finlayson, G. (Graham)|||/items/7c6bfe3b-7403-4ad2-8fc7-178aef24f593 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author_role |
author |
| author2 |
Beaulieu, K. (Kristine)|||/items/22f79b69-93f7-42a6-8695-0c0e689a8725 Almirón-Roig, E. (Eva)|||/items/b81f0e28-3e49-4ac8-ba49-636f956e5315 Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e O'Hara, B. (Beverly)|||/items/921b476c-bfb5-4870-9eec-0dcc6b7ee91c O'Connor, D. (Dominic)|||/items/9936a48f-7a0e-4da4-98ce-5e0d3ad02291 Nazare, J.A. (Julie-Anne)|||/items/a06ca456-81fa-418f-84c4-6a6b976beedb Le Bail, A. (Alain)|||/items/d89abcdf-8d0d-4460-888b-6217bd0bd004 Rannou, C. (Cécile)|||/items/d47a39c1-a444-4413-8636-23a46ef21418 Hardman, C.H. (Charlotte A.)|||/items/48e7a6e8-0daa-4180-ac0c-b6ece0067bf7 Wilton, M. (Moon)|||/items/2711f000-b9a3-42c3-9083-39c2d498ee83 Kjølbæk, L. (Louise)|||/items/c55e8f75-5375-4429-a5d7-f6bea0a23978 Scott, C. (Corey)|||/items/8b255b42-a80e-4c42-bcb7-8dd5ff85c464 Moshoyiannis, H. (Hariklia)|||/items/f4c72a3f-d917-4bf0-8d1b-1a9e09cc57bf Raben, A. (Anne)|||/items/a0dd7aa4-c4fc-4661-8066-d76c26173901 Harrold, J.A. (Joanne A.)|||/items/eb3f9e48-c22b-44ff-9065-982a8a64cd8f Halford, J.C.G. (Jason C. G.)|||/items/b7b4e39e-b449-4951-8ffa-2a5645bf880c Finlayson, G. (Graham)|||/items/7c6bfe3b-7403-4ad2-8fc7-178aef24f593 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Sweeteners Endocrine response Sweetness enhancers Solid food Appetite Glycaemia |
| topic |
Sweeteners Endocrine response Sweetness enhancers Solid food Appetite Glycaemia |
| description |
Background: Sweeteners and sweetness enhancers (S&SE) are used to replace energy yielding sugars and maintain sweet taste in a wide range of products, but controversy exists about their effects on appetite and endocrine responses in reduced or no added sugar solid foods. The aim of the current study was to evaluate the acute (1 day) and repeated (two-week daily) ingestive effects of 2 S&SE vs. sucrose formulations of biscuit with fruit filling on appetite and endocrine responses in adults with overweight and obesity. Methods: In a randomised crossover trial, 53 healthy adults (33 female, 20 male) with overweight/obesity in England and France consumed biscuits with fruit filling containing 1) sucrose, or reformulated with either 2) Stevia Rebaudioside M (StRebM) or 3) Neotame daily during three, two-week intervention periods with a two-week washout. The primary outcome was composite appetite score defined as [desire to eat + hunger + (100 − fullness) + prospective consumption]/4. Findings: Each formulation elicited a similar reduction in appetite sensations (3-h postprandial net iAUC). Postprandial insulin (2-h iAUC) was lower after Neotame (95% CI (0.093, 0.166); p < 0.001; d = −0.71) and StRebM (95% CI (0.133, 0.205); p < 0.001; d = −1.01) compared to sucrose, and glucose was lower after StRebM (95% CI (0.023, 0.171); p < 0.05; d = −0.39) but not after Neotame (95% CI (−0.007, 0.145); p = 0.074; d = −0.25) compared to sucrose. There were no differences between S&SE or sucrose formulations on ghrelin, glucagon-like peptide 1 or pancreatic polypeptide iAUCs. No clinically meaningful differences between acute vs. two-weeks of daily consumption were found. Interpretation: In conclusion, biscuits reformulated to replace sugar using StRebM or Neotame showed no differences in appetite or endocrine responses, acutely or after a two-week exposure, but can reduce postprandial insulin and glucose response in adults with overweight or obesity. Funding: The present study was funded by the Horizon 2020 program: Sweeteners and sweetness enhancers: impact on health, obesity, safety and sustainability (acronym: SWEET, grant no: 774293). |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-09-20 2024 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/69952 |
| url |
https://hdl.handle.net/10171/69952 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869422095802302464 |
| spelling |
Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity—a randomised crossover trial from the SWEET consortiumGibbons, C. (Catherine)|||/items/428f7d30-bd11-48fc-ba3b-84f5007ee034Beaulieu, K. (Kristine)|||/items/22f79b69-93f7-42a6-8695-0c0e689a8725Almirón-Roig, E. (Eva)|||/items/b81f0e28-3e49-4ac8-ba49-636f956e5315Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20eO'Hara, B. (Beverly)|||/items/921b476c-bfb5-4870-9eec-0dcc6b7ee91cO'Connor, D. (Dominic)|||/items/9936a48f-7a0e-4da4-98ce-5e0d3ad02291Nazare, J.A. (Julie-Anne)|||/items/a06ca456-81fa-418f-84c4-6a6b976beedbLe Bail, A. (Alain)|||/items/d89abcdf-8d0d-4460-888b-6217bd0bd004Rannou, C. (Cécile)|||/items/d47a39c1-a444-4413-8636-23a46ef21418Hardman, C.H. (Charlotte A.)|||/items/48e7a6e8-0daa-4180-ac0c-b6ece0067bf7Wilton, M. (Moon)|||/items/2711f000-b9a3-42c3-9083-39c2d498ee83Kjølbæk, L. (Louise)|||/items/c55e8f75-5375-4429-a5d7-f6bea0a23978Scott, C. (Corey)|||/items/8b255b42-a80e-4c42-bcb7-8dd5ff85c464Moshoyiannis, H. (Hariklia)|||/items/f4c72a3f-d917-4bf0-8d1b-1a9e09cc57bfRaben, A. (Anne)|||/items/a0dd7aa4-c4fc-4661-8066-d76c26173901Harrold, J.A. (Joanne A.)|||/items/eb3f9e48-c22b-44ff-9065-982a8a64cd8fHalford, J.C.G. (Jason C. G.)|||/items/b7b4e39e-b449-4951-8ffa-2a5645bf880cFinlayson, G. (Graham)|||/items/7c6bfe3b-7403-4ad2-8fc7-178aef24f593Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131SweetenersEndocrine responseSweetness enhancersSolid foodAppetiteGlycaemiaBackground: Sweeteners and sweetness enhancers (S&SE) are used to replace energy yielding sugars and maintain sweet taste in a wide range of products, but controversy exists about their effects on appetite and endocrine responses in reduced or no added sugar solid foods. The aim of the current study was to evaluate the acute (1 day) and repeated (two-week daily) ingestive effects of 2 S&SE vs. sucrose formulations of biscuit with fruit filling on appetite and endocrine responses in adults with overweight and obesity. Methods: In a randomised crossover trial, 53 healthy adults (33 female, 20 male) with overweight/obesity in England and France consumed biscuits with fruit filling containing 1) sucrose, or reformulated with either 2) Stevia Rebaudioside M (StRebM) or 3) Neotame daily during three, two-week intervention periods with a two-week washout. The primary outcome was composite appetite score defined as [desire to eat + hunger + (100 − fullness) + prospective consumption]/4. Findings: Each formulation elicited a similar reduction in appetite sensations (3-h postprandial net iAUC). Postprandial insulin (2-h iAUC) was lower after Neotame (95% CI (0.093, 0.166); p < 0.001; d = −0.71) and StRebM (95% CI (0.133, 0.205); p < 0.001; d = −1.01) compared to sucrose, and glucose was lower after StRebM (95% CI (0.023, 0.171); p < 0.05; d = −0.39) but not after Neotame (95% CI (−0.007, 0.145); p = 0.074; d = −0.25) compared to sucrose. There were no differences between S&SE or sucrose formulations on ghrelin, glucagon-like peptide 1 or pancreatic polypeptide iAUCs. No clinically meaningful differences between acute vs. two-weeks of daily consumption were found. Interpretation: In conclusion, biscuits reformulated to replace sugar using StRebM or Neotame showed no differences in appetite or endocrine responses, acutely or after a two-week exposure, but can reduce postprandial insulin and glucose response in adults with overweight or obesity. Funding: The present study was funded by the Horizon 2020 program: Sweeteners and sweetness enhancers: impact on health, obesity, safety and sustainability (acronym: SWEET, grant no: 774293).ElsevierDadun. Depósito Académico Digital Universidad de Navarra20242024-09-2020242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/69952reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/699522026-06-21T12:47:57Z |
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15.811543 |