The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2

Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD)....

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Autores: Gispert, Juan Domingo|||0000-0002-6155-0642, Monté, Gemma C., Suárez-Calvet, Marc|||0000-0002-2993-569X, Falcon, Carles, Tucholka, Alan, Rojas Codina, Santiago|||0000-0003-1834-7822, Rami Gonzalez, Lorena|||0000-0002-7411-1921, Sanchez-Valle, Raquel|||0000-0001-7750-896X, Llado Plarrumani, Albert|||0000-0002-5066-4150, Kleinberger, Gernot|||0000-0002-5811-8226, Haass, Christian|||0000-0002-4869-1627, Molinuevo, José Luis|||0000-0003-0485-6001
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186139
Acceso en línea:https://ddd.uab.cat/record/186139
https://dx.doi.org/urn:doi:10.1016/j.dadm.2016.12.002
Access Level:acceso abierto
Palabra clave:Astrogliosis
Microgliosis
TREM2
Glial biomarkers
Inflammation
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spelling The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2Gispert, Juan Domingo|||0000-0002-6155-0642Monté, Gemma C.Suárez-Calvet, Marc|||0000-0002-2993-569XFalcon, CarlesTucholka, AlanRojas Codina, Santiago|||0000-0003-1834-7822Rami Gonzalez, Lorena|||0000-0002-7411-1921Sanchez-Valle, Raquel|||0000-0001-7750-896XLlado Plarrumani, Albert|||0000-0002-5066-4150Kleinberger, Gernot|||0000-0002-5811-8226Haass, Christian|||0000-0002-4869-1627Molinuevo, José Luis|||0000-0003-0485-6001AstrogliosisMicrogliosisTREM2Glial biomarkersInflammationAmong other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). Brain magnetic resonance imaging (MRI) scans were acquired in 110 participants (49 control; 19 preclinical; 27 mild cognitive impairment [MCI] due to AD; 15 mild AD dementia) and CSF concentrations of YKL-40 and sTREM2 were determined. Differences in CSF biomarker concentrations and interactions in their association with gray-matter volume according to APOE ε4 status were sought after. Preclinical and MCI carriers showed higher YKL-40 levels. There was a significant interaction in the association between YKL-40 levels and gray-matter volume according to ε4 status. No similar effects could be detected for sTREM2 levels. Our findings are indicative of an increased astroglial activation in APOE ε4 carriers while both groups displayed similar levels of CSF AD core biomarkers. 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186139https://dx.doi.org/urn:doi:10.1016/j.dadm.2016.12.002reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI14-00282open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1861392026-06-06T12:50:31Z
dc.title.none.fl_str_mv The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
title The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
spellingShingle The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
Gispert, Juan Domingo|||0000-0002-6155-0642
Astrogliosis
Microgliosis
TREM2
Glial biomarkers
Inflammation
title_short The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
title_full The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
title_fullStr The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
title_full_unstemmed The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
title_sort The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
dc.creator.none.fl_str_mv Gispert, Juan Domingo|||0000-0002-6155-0642
Monté, Gemma C.
Suárez-Calvet, Marc|||0000-0002-2993-569X
Falcon, Carles
Tucholka, Alan
Rojas Codina, Santiago|||0000-0003-1834-7822
Rami Gonzalez, Lorena|||0000-0002-7411-1921
Sanchez-Valle, Raquel|||0000-0001-7750-896X
Llado Plarrumani, Albert|||0000-0002-5066-4150
Kleinberger, Gernot|||0000-0002-5811-8226
Haass, Christian|||0000-0002-4869-1627
Molinuevo, José Luis|||0000-0003-0485-6001
author Gispert, Juan Domingo|||0000-0002-6155-0642
author_facet Gispert, Juan Domingo|||0000-0002-6155-0642
Monté, Gemma C.
Suárez-Calvet, Marc|||0000-0002-2993-569X
Falcon, Carles
Tucholka, Alan
Rojas Codina, Santiago|||0000-0003-1834-7822
Rami Gonzalez, Lorena|||0000-0002-7411-1921
Sanchez-Valle, Raquel|||0000-0001-7750-896X
Llado Plarrumani, Albert|||0000-0002-5066-4150
Kleinberger, Gernot|||0000-0002-5811-8226
Haass, Christian|||0000-0002-4869-1627
Molinuevo, José Luis|||0000-0003-0485-6001
author_role author
author2 Monté, Gemma C.
Suárez-Calvet, Marc|||0000-0002-2993-569X
Falcon, Carles
Tucholka, Alan
Rojas Codina, Santiago|||0000-0003-1834-7822
Rami Gonzalez, Lorena|||0000-0002-7411-1921
Sanchez-Valle, Raquel|||0000-0001-7750-896X
Llado Plarrumani, Albert|||0000-0002-5066-4150
Kleinberger, Gernot|||0000-0002-5811-8226
Haass, Christian|||0000-0002-4869-1627
Molinuevo, José Luis|||0000-0003-0485-6001
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Astrogliosis
Microgliosis
TREM2
Glial biomarkers
Inflammation
topic Astrogliosis
Microgliosis
TREM2
Glial biomarkers
Inflammation
description Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). Brain magnetic resonance imaging (MRI) scans were acquired in 110 participants (49 control; 19 preclinical; 27 mild cognitive impairment [MCI] due to AD; 15 mild AD dementia) and CSF concentrations of YKL-40 and sTREM2 were determined. Differences in CSF biomarker concentrations and interactions in their association with gray-matter volume according to APOE ε4 status were sought after. Preclinical and MCI carriers showed higher YKL-40 levels. There was a significant interaction in the association between YKL-40 levels and gray-matter volume according to ε4 status. No similar effects could be detected for sTREM2 levels. Our findings are indicative of an increased astroglial activation in APOE ε4 carriers while both groups displayed similar levels of CSF AD core biomarkers.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186139
https://dx.doi.org/urn:doi:10.1016/j.dadm.2016.12.002
url https://ddd.uab.cat/record/186139
https://dx.doi.org/urn:doi:10.1016/j.dadm.2016.12.002
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI14-00282
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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