Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance

Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic syndrome, or type 2 diabetes. Accordingly, great efforts have been carried out to e...

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Autores: Boughanem, Hatim, Yubero-Serrano, Elena M., López-Miranda, José, Tinahones, Francisco J., Macias-Gonzalez, Manuel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18239
Acceso en línea:http://hdl.handle.net/20.500.12105/18239
Access Level:acceso abierto
Palabra clave:IGFBP2
Obesity
Insulin resistance
Lifestyle modification
Epigenetic
Proteína 2 de unión a factor de crecimiento similar a la insulina
Obesidad
Resistencia a la insulina
Estilo de vida
Epigénesis genética
Diabetes Mellitus, Type 2
Humans
Insulin-Like Growth Factor Binding Protein 2
Insulin Resistance
Quality of Life
Molecular Structure
Exercise
Diet
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spelling Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin ResistanceBoughanem, HatimYubero-Serrano, Elena M.López-Miranda, JoséTinahones, Francisco J.Macias-Gonzalez, ManuelIGFBP2ObesityInsulin resistanceLifestyle modificationEpigeneticProteína 2 de unión a factor de crecimiento similar a la insulinaObesidadResistencia a la insulinaEstilo de vidaEpigénesis genéticaDiabetes Mellitus, Type 2HumansInsulin-Like Growth Factor Binding Protein 2Insulin ResistanceObesityQuality of LifeMolecular StructureExerciseDietEvidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic syndrome, or type 2 diabetes. Accordingly, great efforts have been carried out to explore the role of IGFBP2 in obesity state and insulin-related diseases, which it is typically found decreased. However, the physiological pathways have not been explored yet, and the relevance of IGFBP2 as an important pathway integrator of metabolic disorders is still unknown. Here, we review and discuss the molecular structure of IGFBP2 as the first element of regulating the expression of IGFBP2. We highlight an update of the association between low serum IGFBP2 and an increased risk of obesity, type 2 diabetes, metabolic syndrome, and low insulin sensitivity. We hypothesize mechanisms of IGFBP2 on the development of obesity and insulin resistance in an insulin-independent manner, which meant that could be evaluated as a therapeutic target. Finally, we cover the most interesting lifestyle modifications that regulate IGFBP2, since lifestyle factors (diet and/or physical activity) are associated with important variations in serum IGFBP2.Multidisciplinary Digital Publishing Institute (MDPI)[Boughanem,H; Tinahones,FJ; Macias-Gonzalez,M] Department of Endocrinology and Nutrition, Institute of Biomedical Research Institute in Malaga (IBIMA), Virgen de la Victoria University Hospital, Málaga, Spain. [Yubero-Serrano,EM; López-Miranda,J] Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Yubero-Serrano,EM; López-Miranda,J; Tinahones,FJ; Macias-Gonzalez,M] CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain.20242024-02-1920212021-01-2420212021-01-24research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18239reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/182392026-06-12T12:43:37Z
dc.title.none.fl_str_mv Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
title Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
spellingShingle Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
Boughanem, Hatim
IGFBP2
Obesity
Insulin resistance
Lifestyle modification
Epigenetic
Proteína 2 de unión a factor de crecimiento similar a la insulina
Obesidad
Resistencia a la insulina
Estilo de vida
Epigénesis genética
Diabetes Mellitus, Type 2
Humans
Insulin-Like Growth Factor Binding Protein 2
Insulin Resistance
Obesity
Quality of Life
Molecular Structure
Exercise
Diet
title_short Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
title_full Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
title_fullStr Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
title_full_unstemmed Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
title_sort Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
dc.creator.none.fl_str_mv Boughanem, Hatim
Yubero-Serrano, Elena M.
López-Miranda, José
Tinahones, Francisco J.
Macias-Gonzalez, Manuel
author Boughanem, Hatim
author_facet Boughanem, Hatim
Yubero-Serrano, Elena M.
López-Miranda, José
Tinahones, Francisco J.
Macias-Gonzalez, Manuel
author_role author
author2 Yubero-Serrano, Elena M.
López-Miranda, José
Tinahones, Francisco J.
Macias-Gonzalez, Manuel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv [Boughanem,H; Tinahones,FJ; Macias-Gonzalez,M] Department of Endocrinology and Nutrition, Institute of Biomedical Research Institute in Malaga (IBIMA), Virgen de la Victoria University Hospital, Málaga, Spain. [Yubero-Serrano,EM; López-Miranda,J] Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Yubero-Serrano,EM; López-Miranda,J; Tinahones,FJ; Macias-Gonzalez,M] CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain.
dc.subject.none.fl_str_mv IGFBP2
Obesity
Insulin resistance
Lifestyle modification
Epigenetic
Proteína 2 de unión a factor de crecimiento similar a la insulina
Obesidad
Resistencia a la insulina
Estilo de vida
Epigénesis genética
Diabetes Mellitus, Type 2
Humans
Insulin-Like Growth Factor Binding Protein 2
Insulin Resistance
Obesity
Quality of Life
Molecular Structure
Exercise
Diet
topic IGFBP2
Obesity
Insulin resistance
Lifestyle modification
Epigenetic
Proteína 2 de unión a factor de crecimiento similar a la insulina
Obesidad
Resistencia a la insulina
Estilo de vida
Epigénesis genética
Diabetes Mellitus, Type 2
Humans
Insulin-Like Growth Factor Binding Protein 2
Insulin Resistance
Obesity
Quality of Life
Molecular Structure
Exercise
Diet
description Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic syndrome, or type 2 diabetes. Accordingly, great efforts have been carried out to explore the role of IGFBP2 in obesity state and insulin-related diseases, which it is typically found decreased. However, the physiological pathways have not been explored yet, and the relevance of IGFBP2 as an important pathway integrator of metabolic disorders is still unknown. Here, we review and discuss the molecular structure of IGFBP2 as the first element of regulating the expression of IGFBP2. We highlight an update of the association between low serum IGFBP2 and an increased risk of obesity, type 2 diabetes, metabolic syndrome, and low insulin sensitivity. We hypothesize mechanisms of IGFBP2 on the development of obesity and insulin resistance in an insulin-independent manner, which meant that could be evaluated as a therapeutic target. Finally, we cover the most interesting lifestyle modifications that regulate IGFBP2, since lifestyle factors (diet and/or physical activity) are associated with important variations in serum IGFBP2.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-24
2021
2021-01-24
2024
2024-02-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18239
url http://hdl.handle.net/20.500.12105/18239
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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