Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study

Agranulocitosis; Antitiroideos; Carbimazol

Detalhes bibliográficos
Autores: García Gómez, Carlos, Navarro, Elena, Alcázar, Victoria, López-Guzmán, Antonio, Arrieta, Francisco, EMMA, ANDA, Biagetti, Betina
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10579
Acesso em linha:https://hdl.handle.net/11351/10579
http://hdl.handle.net/11351/10579
Access Level:acceso abierto
Palavra-chave:Hipertiroïdisme - Tractament
Medicaments - Efectes secundaris
Agranulocitosi
DISEASES::Endocrine System Diseases::Thyroid Diseases::Hyperthyroidism
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Antithyroid Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::Agranulocytosis
Other subheadings::Other subheadings::Other subheadings::/chemically induced
ENFERMEDADES::enfermedades del sistema endocrino::enfermedades tiroideas::hipertiroidismo
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::antagonistas de hormonas::antitiroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos leucocitarios::leucopenia::agranulocitosis
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
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oai_identifier_str oai:recercat.cat:11351/10579
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
title Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
spellingShingle Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
García Gómez, Carlos
Hipertiroïdisme - Tractament
Medicaments - Efectes secundaris
Agranulocitosi
DISEASES::Endocrine System Diseases::Thyroid Diseases::Hyperthyroidism
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Antithyroid Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::Agranulocytosis
Other subheadings::Other subheadings::Other subheadings::/chemically induced
ENFERMEDADES::enfermedades del sistema endocrino::enfermedades tiroideas::hipertiroidismo
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::antagonistas de hormonas::antitiroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos leucocitarios::leucopenia::agranulocitosis
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
title_short Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
title_full Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
title_fullStr Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
title_full_unstemmed Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
title_sort Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter Study
dc.creator.none.fl_str_mv García Gómez, Carlos
Navarro, Elena
Alcázar, Victoria
López-Guzmán, Antonio
Arrieta, Francisco
EMMA, ANDA
Biagetti, Betina
author García Gómez, Carlos
author_facet García Gómez, Carlos
Navarro, Elena
Alcázar, Victoria
López-Guzmán, Antonio
Arrieta, Francisco
EMMA, ANDA
Biagetti, Betina
author_role author
author2 Navarro, Elena
Alcázar, Victoria
López-Guzmán, Antonio
Arrieta, Francisco
EMMA, ANDA
Biagetti, Betina
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[García Gómez C] Department of Endocrinology and Nutrition, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana (IDIPHISA), Madrid, Spain. Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain. [Navarro E] Department of Endocrinology and Nutrition, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Alcázar V] Department of Endocrinology and Nutrition, Hospital Universitario Severo Ochoa, Madrid, Spain. [López-Guzmán A] Department of Endocrinology and Nutrition, Complejo Asistencial de Ávila, Ávila, Spain. [Arrieta F] Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Anda E] Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, Pamplona, Spain. [Biagetti B] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hipertiroïdisme - Tractament
Medicaments - Efectes secundaris
Agranulocitosi
DISEASES::Endocrine System Diseases::Thyroid Diseases::Hyperthyroidism
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Antithyroid Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::Agranulocytosis
Other subheadings::Other subheadings::Other subheadings::/chemically induced
ENFERMEDADES::enfermedades del sistema endocrino::enfermedades tiroideas::hipertiroidismo
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::antagonistas de hormonas::antitiroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos leucocitarios::leucopenia::agranulocitosis
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
topic Hipertiroïdisme - Tractament
Medicaments - Efectes secundaris
Agranulocitosi
DISEASES::Endocrine System Diseases::Thyroid Diseases::Hyperthyroidism
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Antithyroid Agents
Other subheadings::Other subheadings::Other subheadings::/adverse effects
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::Agranulocytosis
Other subheadings::Other subheadings::Other subheadings::/chemically induced
ENFERMEDADES::enfermedades del sistema endocrino::enfermedades tiroideas::hipertiroidismo
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::antagonistas de hormonas::antitiroideos
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos leucocitarios::leucopenia::agranulocitosis
Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
description Agranulocitosis; Antitiroideos; Carbimazol
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10579
http://hdl.handle.net/11351/10579
url https://hdl.handle.net/11351/10579
http://hdl.handle.net/11351/10579
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine;12(20)
https://doi.org/10.3390/jcm12206556
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422094008188928
spelling Therapeutic Management and Long-Term Outcome of Hyperthyroidism in Patients with Antithyroid-Induced Agranulocytosis: A Retrospective, Multicenter StudyGarcía Gómez, CarlosNavarro, ElenaAlcázar, VictoriaLópez-Guzmán, AntonioArrieta, FranciscoEMMA, ANDABiagetti, BetinaHipertiroïdisme - TractamentMedicaments - Efectes secundarisAgranulocitosiDISEASES::Endocrine System Diseases::Thyroid Diseases::HyperthyroidismCHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Antithyroid AgentsOther subheadings::Other subheadings::Other subheadings::/adverse effectsDISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::AgranulocytosisOther subheadings::Other subheadings::Other subheadings::/chemically inducedENFERMEDADES::enfermedades del sistema endocrino::enfermedades tiroideas::hipertiroidismoCOMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::antagonistas de hormonas::antitiroideosOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos leucocitarios::leucopenia::agranulocitosisOtros calificadores::Otros calificadores::Otros calificadores::/inducido químicamenteAgranulocitosis; Antitiroideos; CarbimazolAgranulocitosi; Antitiroïdals; CarbimazolAgranulocytosis; Antithyroid; CarbimazoleBackground: Antithyroid drug-induced agranulocytosis (AIA) (neutrophils <500/µL) is a rare but serious complication in the treatment of hyperthyroidism. Methodology: Adult patients with AIA who were followed up at 12 hospitals in Spain were retrospectively studied. A total of 29 patients were studied. The etiology of hyperthyroidism was distributed as follows: Graves’ disease (n = 21), amiodarone-induced thyrotoxicosis (n = 7), and hyperfunctioning multinodular goiter (n = 1). Twenty-one patients were treated with methimazole, as well as six patients with carbimazole and two patients with propylthiouracil. Results: The median (IQR) time to development of agranulocytosis was 6.0 (4.0–11.5) weeks. The most common presenting sign was fever accompanied by odynophagia. All of the patients required admission, reverse isolation, and broad-spectrum antibiotics; moreover, G-CSF was administered to 26 patients (89.7%). Twenty-one patients received definitive treatment, thirteen patients received surgery, nine patients received radioiodine, and one of the patients required both treatments. Spontaneous normalization of thyroid hormone values occurred in six patients (four patients with amiodarone-induced thyrotoxicosis and two patients with Graves’ disease), and two patients died of septic shock secondary to AIA. Conclusions: AIA is a potentially lethal complication that usually appears around 6 weeks after the initiation of antithyroid therapy. Multiple drugs are required to control hyperthyroidism before definitive treatment; additionally, in a significant percentage of patients (mainly in those treated with amiodarone), hyperthyroidism resolved spontaneously.MDPIInstitut Català de la Salut[García Gómez C] Department of Endocrinology and Nutrition, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana (IDIPHISA), Madrid, Spain. Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain. [Navarro E] Department of Endocrinology and Nutrition, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Alcázar V] Department of Endocrinology and Nutrition, Hospital Universitario Severo Ochoa, Madrid, Spain. [López-Guzmán A] Department of Endocrinology and Nutrition, Complejo Asistencial de Ávila, Ávila, Spain. [Arrieta F] Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Anda E] Department of Endocrinology and Nutrition, Complejo Hospitalario de Navarra, Pamplona, Spain. [Biagetti B] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/10579http://hdl.handle.net/11351/10579Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Clinical Medicine;12(20)https://doi.org/10.3390/jcm12206556Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/105792026-05-29T05:05:01Z
score 15,812455

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