Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention

The consumption of low-alcohol fermented beverages has been related to cardiovascular health improvements. Although the underlying mechanism is not completely understood, (poly)phenols have been proposed as one of the mediators. The objective of this study was to evaluate the impact of a controlled...

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Autores: Hinojosa-Nogueira, Daniel, Díaz-Perdigones, Cristina María, García-López, María José, Marcos, Ascensión, Portillo, María P., Lamuela Raventós, Rosa Ma., Subiri-Verdugo, Alba, Nova, Esther, Milton-Laskibar, Iñaki, Galkina, Polina, Tinahones, Francisco J., Moreno-Indias, Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/223561
Acceso en línea:https://hdl.handle.net/2445/223561
Access Level:acceso abierto
Palabra clave:Polifenols
Fenols
Cervesa
Antioxidants
Polyphenols
Phenols
Beer
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spelling Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary InterventionHinojosa-Nogueira, DanielDíaz-Perdigones, Cristina MaríaGarcía-López, María JoséMarcos, AscensiónPortillo, María P.Lamuela Raventós, Rosa Ma.Subiri-Verdugo, AlbaNova, EstherMilton-Laskibar, IñakiGalkina, PolinaTinahones, Francisco J.Moreno-Indias, IsabelPolifenolsFenolsCervesaAntioxidantsPolyphenolsPhenolsBeerAntioxidantsThe consumption of low-alcohol fermented beverages has been related to cardiovascular health improvements. Although the underlying mechanism is not completely understood, (poly)phenols have been proposed as one of the mediators. The objective of this study was to evaluate the impact of a controlled intervention with beer on (poly)phenols metabolism in individuals with and without metabolic syndrome (MetS). 20 participants (MetS and control) who consumed a standardized amount of beer during 6 weeks were recruited. Phenolic compounds were assessed in urine. Different changes in phenolic compounds associated with chronic beer consumption were found, particularly related to hesperetin conjugates and to the degradation of phenolic compounds derived from flavonoids and lignans. Noteworthily, MetS and control participants differed in baseline urine phenolic compound profiles and in their metabolization. Significant differences were found in the production and excretion of key (poly)phenols-derived metabolites, such as increased naringenin phase II conjugates in healthy subjects, or increased bacterial flavonoid catabolites. Certain relationships were observed between the phenolic compounds with metabolic and anthropometric variables. These findings suggest that beer-derived (poly)phenols are differentially metabolized according to metabolic-health status, and that they may contribute to certain metabolic health benefits through the modulation of specific metabolic pathways.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/223561Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/molecules30142932Molecules, 2025, vol. 30, num.14https://doi.org/10.3390/molecules30142932cc-by (c) Hinojosa-Nogueira, D. et al., 2025http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2235612026-05-27T06:46:51Z
dc.title.none.fl_str_mv Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
title Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
spellingShingle Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
Hinojosa-Nogueira, Daniel
Polifenols
Fenols
Cervesa
Antioxidants
Polyphenols
Phenols
Beer
Antioxidants
title_short Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
title_full Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
title_fullStr Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
title_full_unstemmed Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
title_sort Beer-Derived (Poly)phenol Metabolism in Individuals With and Without Metabolic Syndrome: A Comparative Dietary Intervention
dc.creator.none.fl_str_mv Hinojosa-Nogueira, Daniel
Díaz-Perdigones, Cristina María
García-López, María José
Marcos, Ascensión
Portillo, María P.
Lamuela Raventós, Rosa Ma.
Subiri-Verdugo, Alba
Nova, Esther
Milton-Laskibar, Iñaki
Galkina, Polina
Tinahones, Francisco J.
Moreno-Indias, Isabel
author Hinojosa-Nogueira, Daniel
author_facet Hinojosa-Nogueira, Daniel
Díaz-Perdigones, Cristina María
García-López, María José
Marcos, Ascensión
Portillo, María P.
Lamuela Raventós, Rosa Ma.
Subiri-Verdugo, Alba
Nova, Esther
Milton-Laskibar, Iñaki
Galkina, Polina
Tinahones, Francisco J.
Moreno-Indias, Isabel
author_role author
author2 Díaz-Perdigones, Cristina María
García-López, María José
Marcos, Ascensión
Portillo, María P.
Lamuela Raventós, Rosa Ma.
Subiri-Verdugo, Alba
Nova, Esther
Milton-Laskibar, Iñaki
Galkina, Polina
Tinahones, Francisco J.
Moreno-Indias, Isabel
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Polifenols
Fenols
Cervesa
Antioxidants
Polyphenols
Phenols
Beer
Antioxidants
topic Polifenols
Fenols
Cervesa
Antioxidants
Polyphenols
Phenols
Beer
Antioxidants
description The consumption of low-alcohol fermented beverages has been related to cardiovascular health improvements. Although the underlying mechanism is not completely understood, (poly)phenols have been proposed as one of the mediators. The objective of this study was to evaluate the impact of a controlled intervention with beer on (poly)phenols metabolism in individuals with and without metabolic syndrome (MetS). 20 participants (MetS and control) who consumed a standardized amount of beer during 6 weeks were recruited. Phenolic compounds were assessed in urine. Different changes in phenolic compounds associated with chronic beer consumption were found, particularly related to hesperetin conjugates and to the degradation of phenolic compounds derived from flavonoids and lignans. Noteworthily, MetS and control participants differed in baseline urine phenolic compound profiles and in their metabolization. Significant differences were found in the production and excretion of key (poly)phenols-derived metabolites, such as increased naringenin phase II conjugates in healthy subjects, or increased bacterial flavonoid catabolites. Certain relationships were observed between the phenolic compounds with metabolic and anthropometric variables. These findings suggest that beer-derived (poly)phenols are differentially metabolized according to metabolic-health status, and that they may contribute to certain metabolic health benefits through the modulation of specific metabolic pathways.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223561
url https://hdl.handle.net/2445/223561
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/molecules30142932
Molecules, 2025, vol. 30, num.14
https://doi.org/10.3390/molecules30142932
dc.rights.none.fl_str_mv cc-by (c) Hinojosa-Nogueira, D. et al., 2025
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Hinojosa-Nogueira, D. et al., 2025
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422093496483840
score 15,81155

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