Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system
Hyperoxia is used in order to counteract hypoxia effects in the TME (tumor microenvironment), which are described to boost the malignant tumor phenotype and poor prognosis. The reduction of tumor hypoxic state through the formation of a non-aberrant vasculature or an increase in the toxicity of the...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:dadun_______::22d9a7574b5fc5185b2e6f0f0f07d25b |
| Acceso en línea: | https://hdl.handle.net/10171/124383 |
| Access Level: | acceso abierto |
| Palabra clave: | Hyperoxia Hypoxia Immunotherapy Inflammation Tumor microenvironment |
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Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune systemHerrera-Campos, A.B. (Ana Belén)|||/items/2049748b-1748-4e08-940b-4bb265b59972Zamudio-Martinez, E. (Esteban)|||/items/583f9b8d-5a10-46e9-ac54-85c250c79c4aDelgado-Bellido, D. (Daniel)|||/items/e6a02c52-1530-4de4-b860-9c3653398a46Fernández-Cortés, M. (Mónica)|||/items/f6e75e82-e51b-4df6-be80-d4e817e42748Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596Oliver, F.J. (F. Javier)|||/items/095cbbd2-89b7-4779-b5c7-085b2d6a1443Garcia-Diaz, A. (Angel)|||/items/da88ab38-e126-4ca0-939e-ab03126634e2HyperoxiaHypoxiaImmunotherapyInflammationTumor microenvironmentHyperoxia is used in order to counteract hypoxia effects in the TME (tumor microenvironment), which are described to boost the malignant tumor phenotype and poor prognosis. The reduction of tumor hypoxic state through the formation of a non-aberrant vasculature or an increase in the toxicity of the therapeutic agent improves the efficacy of therapies such as chemotherapy. Radiotherapy efficacy has also improved, where apoptotic mechanisms seem to be implicated. Moreover, hyperoxia increases the antitumor immunity through diverse pathways, leading to an immunopermissive TME. Although hyperoxia is an approved treatment for preventing and treating hypoxemia, it has harmful side-effects. Prolonged exposure to high oxygen levels may cause acute lung injury, characterized by an exacerbated immune response, and the destruction of the alveolar-capillary barrier. Furthermore, under this situation, the high concentration of ROS may cause toxicity that will lead not only to cell death but also to an increase in chemoattractant and proinflammatory cytokine secretion. This would end in a lung leukocyte recruitment and, therefore, lung damage. Moreover, unregulated inflammation causes different consequences promoting tumor development and metastasis. This process is known as protumor inflammation, where different cell types and molecules are implicated; for instance, IL-1β has been described as a key cytokine. Although current results show benefits over cancer therapies using hyperoxia, further studies need to be conducted, not only to improve tumor regression, but also to prevent its collateral damage.MDPIDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/124383reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dnet:dadun_______::22d9a7574b5fc5185b2e6f0f0f07d25b2026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system |
| title |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system |
| spellingShingle |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system Herrera-Campos, A.B. (Ana Belén)|||/items/2049748b-1748-4e08-940b-4bb265b59972 Hyperoxia Hypoxia Immunotherapy Inflammation Tumor microenvironment |
| title_short |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system |
| title_full |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system |
| title_fullStr |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system |
| title_full_unstemmed |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system |
| title_sort |
Implications of hyperoxia over the tumor microenvironment: an overview highlighting the importance of the immune system |
| dc.creator.none.fl_str_mv |
Herrera-Campos, A.B. (Ana Belén)|||/items/2049748b-1748-4e08-940b-4bb265b59972 Zamudio-Martinez, E. (Esteban)|||/items/583f9b8d-5a10-46e9-ac54-85c250c79c4a Delgado-Bellido, D. (Daniel)|||/items/e6a02c52-1530-4de4-b860-9c3653398a46 Fernández-Cortés, M. (Mónica)|||/items/f6e75e82-e51b-4df6-be80-d4e817e42748 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Oliver, F.J. (F. Javier)|||/items/095cbbd2-89b7-4779-b5c7-085b2d6a1443 Garcia-Diaz, A. (Angel)|||/items/da88ab38-e126-4ca0-939e-ab03126634e2 |
| author |
Herrera-Campos, A.B. (Ana Belén)|||/items/2049748b-1748-4e08-940b-4bb265b59972 |
| author_facet |
Herrera-Campos, A.B. (Ana Belén)|||/items/2049748b-1748-4e08-940b-4bb265b59972 Zamudio-Martinez, E. (Esteban)|||/items/583f9b8d-5a10-46e9-ac54-85c250c79c4a Delgado-Bellido, D. (Daniel)|||/items/e6a02c52-1530-4de4-b860-9c3653398a46 Fernández-Cortés, M. (Mónica)|||/items/f6e75e82-e51b-4df6-be80-d4e817e42748 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Oliver, F.J. (F. Javier)|||/items/095cbbd2-89b7-4779-b5c7-085b2d6a1443 Garcia-Diaz, A. (Angel)|||/items/da88ab38-e126-4ca0-939e-ab03126634e2 |
| author_role |
author |
| author2 |
Zamudio-Martinez, E. (Esteban)|||/items/583f9b8d-5a10-46e9-ac54-85c250c79c4a Delgado-Bellido, D. (Daniel)|||/items/e6a02c52-1530-4de4-b860-9c3653398a46 Fernández-Cortés, M. (Mónica)|||/items/f6e75e82-e51b-4df6-be80-d4e817e42748 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Oliver, F.J. (F. Javier)|||/items/095cbbd2-89b7-4779-b5c7-085b2d6a1443 Garcia-Diaz, A. (Angel)|||/items/da88ab38-e126-4ca0-939e-ab03126634e2 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Hyperoxia Hypoxia Immunotherapy Inflammation Tumor microenvironment |
| topic |
Hyperoxia Hypoxia Immunotherapy Inflammation Tumor microenvironment |
| description |
Hyperoxia is used in order to counteract hypoxia effects in the TME (tumor microenvironment), which are described to boost the malignant tumor phenotype and poor prognosis. The reduction of tumor hypoxic state through the formation of a non-aberrant vasculature or an increase in the toxicity of the therapeutic agent improves the efficacy of therapies such as chemotherapy. Radiotherapy efficacy has also improved, where apoptotic mechanisms seem to be implicated. Moreover, hyperoxia increases the antitumor immunity through diverse pathways, leading to an immunopermissive TME. Although hyperoxia is an approved treatment for preventing and treating hypoxemia, it has harmful side-effects. Prolonged exposure to high oxygen levels may cause acute lung injury, characterized by an exacerbated immune response, and the destruction of the alveolar-capillary barrier. Furthermore, under this situation, the high concentration of ROS may cause toxicity that will lead not only to cell death but also to an increase in chemoattractant and proinflammatory cytokine secretion. This would end in a lung leukocyte recruitment and, therefore, lung damage. Moreover, unregulated inflammation causes different consequences promoting tumor development and metastasis. This process is known as protumor inflammation, where different cell types and molecules are implicated; for instance, IL-1β has been described as a key cytokine. Although current results show benefits over cancer therapies using hyperoxia, further studies need to be conducted, not only to improve tumor regression, but also to prevent its collateral damage. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/124383 |
| url |
https://hdl.handle.net/10171/124383 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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