Autophagy in Tissue Repair and Regeneration

Autophagy is a cellular recycling system that, through the sequestration and degradation of intracellular components regulates multiple cellular functions to maintain cellular homeostasis and survival. Dysregulation of autophagy is closely associated with the development of physiological alterations...

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Detalles Bibliográficos
Autores: Moreno-Blas, Daniel, Adell i Creixell, Teresa, González Estévez, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/219657
Acceso en línea:https://hdl.handle.net/2445/219657
Access Level:acceso abierto
Palabra clave:Autofàgia
Cèl·lules mare
Regeneració (Biologia)
Autophagy
Stem cells
Regeneration (Biology)
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spelling Autophagy in Tissue Repair and RegenerationMoreno-Blas, DanielAdell i Creixell, TeresaGonzález Estévez, CristinaAutofàgiaCèl·lules mareRegeneració (Biologia)AutophagyStem cellsRegeneration (Biology)Autophagy is a cellular recycling system that, through the sequestration and degradation of intracellular components regulates multiple cellular functions to maintain cellular homeostasis and survival. Dysregulation of autophagy is closely associated with the development of physiological alterations and human diseases, including the loss of regenerative capacity. Tissue regeneration is a highly complex process that relies on the coordinated interplay of several cellular processes, such as injury sensing, defense responses, cell proliferation, differentiation, migration, and cellular senescence. These processes act synergistically to repair or replace damaged tissues and restore their morphology and function. In this review, we examine the evidence supporting the involvement of the autophagy pathway in the different cellular mechanisms comprising the processes of regeneration and repair across different regenerative contexts. Additionally, we explore how modulating autophagy can enhance or accelerate regeneration and repair, highlighting autophagy as a promising therapeutic target in regenerative medicine for the development of autophagy-based treatments for human diseases.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/219657Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cells14040282Cells, 2025, vol. 14, num.4, p. 1-28https://doi.org/10.3390/cells14040282cc-by (c) Moreno-Blas, D. et al., 2025http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2196572026-05-27T06:46:51Z
dc.title.none.fl_str_mv Autophagy in Tissue Repair and Regeneration
title Autophagy in Tissue Repair and Regeneration
spellingShingle Autophagy in Tissue Repair and Regeneration
Moreno-Blas, Daniel
Autofàgia
Cèl·lules mare
Regeneració (Biologia)
Autophagy
Stem cells
Regeneration (Biology)
title_short Autophagy in Tissue Repair and Regeneration
title_full Autophagy in Tissue Repair and Regeneration
title_fullStr Autophagy in Tissue Repair and Regeneration
title_full_unstemmed Autophagy in Tissue Repair and Regeneration
title_sort Autophagy in Tissue Repair and Regeneration
dc.creator.none.fl_str_mv Moreno-Blas, Daniel
Adell i Creixell, Teresa
González Estévez, Cristina
author Moreno-Blas, Daniel
author_facet Moreno-Blas, Daniel
Adell i Creixell, Teresa
González Estévez, Cristina
author_role author
author2 Adell i Creixell, Teresa
González Estévez, Cristina
author2_role author
author
dc.subject.none.fl_str_mv Autofàgia
Cèl·lules mare
Regeneració (Biologia)
Autophagy
Stem cells
Regeneration (Biology)
topic Autofàgia
Cèl·lules mare
Regeneració (Biologia)
Autophagy
Stem cells
Regeneration (Biology)
description Autophagy is a cellular recycling system that, through the sequestration and degradation of intracellular components regulates multiple cellular functions to maintain cellular homeostasis and survival. Dysregulation of autophagy is closely associated with the development of physiological alterations and human diseases, including the loss of regenerative capacity. Tissue regeneration is a highly complex process that relies on the coordinated interplay of several cellular processes, such as injury sensing, defense responses, cell proliferation, differentiation, migration, and cellular senescence. These processes act synergistically to repair or replace damaged tissues and restore their morphology and function. In this review, we examine the evidence supporting the involvement of the autophagy pathway in the different cellular mechanisms comprising the processes of regeneration and repair across different regenerative contexts. Additionally, we explore how modulating autophagy can enhance or accelerate regeneration and repair, highlighting autophagy as a promising therapeutic target in regenerative medicine for the development of autophagy-based treatments for human diseases.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219657
url https://hdl.handle.net/2445/219657
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cells14040282
Cells, 2025, vol. 14, num.4, p. 1-28
https://doi.org/10.3390/cells14040282
dc.rights.none.fl_str_mv cc-by (c) Moreno-Blas, D. et al., 2025
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Moreno-Blas, D. et al., 2025
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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