Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study
Background The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability of an expert team and the volume of surgeries performed. Data on the outcomes of TSS for PA are scarce in our country. TESSPAIN evaluates TSS outcomes in Spanish cen...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p19548 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19548 |
| Access Level: | acceso abierto |
| Palabra clave: | transsphenoidal surgery pituitary adenoma surgical complications success rate surgical experience surgical specialization |
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Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter studyPaja, MSoto, AHanzu, FAGuerrero-Pérez, FCámara, RMoure, DGálvez, ASimó-Servat, AVillar-Taibo, RCalatayud, MVicente, ARecio-Córdova, JMSerra, GRojas-Marcos, PMParra-Ramírez, PAraujo-Castro, MLibrizzi, SIrigaray, AOllero, DAznar, SMuñoz, FAulinas, AGonzález-Fernández, LGarcía-Centeno, REgaña, NGonzález-Vidal, TMenéndez, EDelgado, AMAbarca, JSottile, JPicó, AMNovo, COrtiz, ITenorio, Cde León, Rde Pablos-Velasco, PCrespo, CPeñalver, DDíaz-Soto, GPuig-Domingo, MBiagetti, Btranssphenoidal surgerypituitary adenomasurgical complicationssuccess ratesurgical experiencesurgical specializationBackground The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability of an expert team and the volume of surgeries performed. Data on the outcomes of TSS for PA are scarce in our country. TESSPAIN evaluates TSS outcomes in Spanish centers to assess the influence of surgical volume and specialized neurosurgical teams on success and complication rates. Methods A retrospective, nationwide, study of Spanish centers performing TSS between January 2018 and December 2022. Centers were classified as high volume (HV) [n=11, defined as centers with recognized expertise in Spain or those performing more than 25 TSS/year] or non-HV. Data collection included surgical success rates, complications, and pituitary adenoma resectability (R-PA). Additional analyses evaluated the impact of dedicated neurosurgical teams (DNT) within HV centers. Results A total of 2815 TSS from 29 Spanish centers were included (1421 NSPA, 436 GH-secreting, 323 Cushing's disease, 127 PRL-secreting and 25 TSH-secreting PA). The overall success rate was 50.5%, 76.8% for R-PA. HV centers had a higher overall success rate (53.1 vs. 47.7%; p=0.03). Better TSS outcomes for NSPA accounted for this difference. The overall TSS complication rate was 22.1%, which was higher for NSPA than for SPA (25.0 vs. 17.7%). The overall complication rate of TSS for PA was significantly higher in non-HV centers than in HV centers (24 vs 20.4.0; p <0.01). Centers with a DNT showed a trend to higher success rate in R-PA, while having a lower overall incidence of complications in TSS for PA than HV centers without a DNT (18.5 vs. 23.0; p=0.058), mainly reducing the rate of permanent ADH deficiency in all TSS for PA (2.7 vs. 8.4%; p<0.001). Conclusion Higher surgical volume and DNT are associated with improved TSS outcomes for PA in Spain. Our results support the recommendation of concentration of pituitary surgery in a reduced number of centers of expertise in our country in order to improve the success rate and reduce complications, mainly postoperative ADH deficiency.FRONTIERS MEDIA SA2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19548Frontiers in EndocrinologyISSN: 16642392reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p195482026-06-14T12:41:47Z |
| dc.title.none.fl_str_mv |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study |
| title |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study |
| spellingShingle |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study Paja, M transsphenoidal surgery pituitary adenoma surgical complications success rate surgical experience surgical specialization |
| title_short |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study |
| title_full |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study |
| title_fullStr |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study |
| title_full_unstemmed |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study |
| title_sort |
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study |
| dc.creator.none.fl_str_mv |
Paja, M Soto, A Hanzu, FA Guerrero-Pérez, F Cámara, R Moure, D Gálvez, A Simó-Servat, A Villar-Taibo, R Calatayud, M Vicente, A Recio-Córdova, JM Serra, G Rojas-Marcos, PM Parra-Ramírez, P Araujo-Castro, M Librizzi, S Irigaray, A Ollero, D Aznar, S Muñoz, F Aulinas, A González-Fernández, L García-Centeno, R Egaña, N González-Vidal, T Menéndez, E Delgado, AM Abarca, J Sottile, J Picó, AM Novo, C Ortiz, I Tenorio, C de León, R de Pablos-Velasco, P Crespo, C Peñalver, D Díaz-Soto, G Puig-Domingo, M Biagetti, B |
| author |
Paja, M |
| author_facet |
Paja, M Soto, A Hanzu, FA Guerrero-Pérez, F Cámara, R Moure, D Gálvez, A Simó-Servat, A Villar-Taibo, R Calatayud, M Vicente, A Recio-Córdova, JM Serra, G Rojas-Marcos, PM Parra-Ramírez, P Araujo-Castro, M Librizzi, S Irigaray, A Ollero, D Aznar, S Muñoz, F Aulinas, A González-Fernández, L García-Centeno, R Egaña, N González-Vidal, T Menéndez, E Delgado, AM Abarca, J Sottile, J Picó, AM Novo, C Ortiz, I Tenorio, C de León, R de Pablos-Velasco, P Crespo, C Peñalver, D Díaz-Soto, G Puig-Domingo, M Biagetti, B |
| author_role |
author |
| author2 |
Soto, A Hanzu, FA Guerrero-Pérez, F Cámara, R Moure, D Gálvez, A Simó-Servat, A Villar-Taibo, R Calatayud, M Vicente, A Recio-Córdova, JM Serra, G Rojas-Marcos, PM Parra-Ramírez, P Araujo-Castro, M Librizzi, S Irigaray, A Ollero, D Aznar, S Muñoz, F Aulinas, A González-Fernández, L García-Centeno, R Egaña, N González-Vidal, T Menéndez, E Delgado, AM Abarca, J Sottile, J Picó, AM Novo, C Ortiz, I Tenorio, C de León, R de Pablos-Velasco, P Crespo, C Peñalver, D Díaz-Soto, G Puig-Domingo, M Biagetti, B |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
transsphenoidal surgery pituitary adenoma surgical complications success rate surgical experience surgical specialization |
| topic |
transsphenoidal surgery pituitary adenoma surgical complications success rate surgical experience surgical specialization |
| description |
Background The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability of an expert team and the volume of surgeries performed. Data on the outcomes of TSS for PA are scarce in our country. TESSPAIN evaluates TSS outcomes in Spanish centers to assess the influence of surgical volume and specialized neurosurgical teams on success and complication rates. Methods A retrospective, nationwide, study of Spanish centers performing TSS between January 2018 and December 2022. Centers were classified as high volume (HV) [n=11, defined as centers with recognized expertise in Spain or those performing more than 25 TSS/year] or non-HV. Data collection included surgical success rates, complications, and pituitary adenoma resectability (R-PA). Additional analyses evaluated the impact of dedicated neurosurgical teams (DNT) within HV centers. Results A total of 2815 TSS from 29 Spanish centers were included (1421 NSPA, 436 GH-secreting, 323 Cushing's disease, 127 PRL-secreting and 25 TSH-secreting PA). The overall success rate was 50.5%, 76.8% for R-PA. HV centers had a higher overall success rate (53.1 vs. 47.7%; p=0.03). Better TSS outcomes for NSPA accounted for this difference. The overall TSS complication rate was 22.1%, which was higher for NSPA than for SPA (25.0 vs. 17.7%). The overall complication rate of TSS for PA was significantly higher in non-HV centers than in HV centers (24 vs 20.4.0; p <0.01). Centers with a DNT showed a trend to higher success rate in R-PA, while having a lower overall incidence of complications in TSS for PA than HV centers without a DNT (18.5 vs. 23.0; p=0.058), mainly reducing the rate of permanent ADH deficiency in all TSS for PA (2.7 vs. 8.4%; p<0.001). Conclusion Higher surgical volume and DNT are associated with improved TSS outcomes for PA in Spain. Our results support the recommendation of concentration of pituitary surgery in a reduced number of centers of expertise in our country in order to improve the success rate and reduce complications, mainly postoperative ADH deficiency. |
| publishDate |
2025 |
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2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19548 |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19548 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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FRONTIERS MEDIA SA |
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FRONTIERS MEDIA SA |
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Frontiers in Endocrinology ISSN: 16642392 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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