Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique
The RTS,S/AS01 - " vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 clinical trial using a 3-dose immunization schedule. A fourth-dose 18 months after the primary vaccination was shown to restore the waning efficacy. However, only total IgG against the immunodomi...
| Autores: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/182854 |
| Acceso en línea: | https://hdl.handle.net/2445/182854 |
| Access Level: | acceso abierto |
| Palabra clave: | Vacuna de la malària Pediatria Assaigs clínics Malaria vaccine Pediatrics Clinical trials |
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Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in MozambiqueSánchez, LinaVidal, MartaJairoce, Chenjerai Tobias SixpenceAguilar, RuthUbillos, ItziarCuamba, InocenciaNhabomba, Augusto J.Williams, Nana AbaDíez Padrisa, NúriaCavanagh, DavidAngov, EvelinaCoppel, Ross L.Gaur, DeepakBeeson, James G.Dutta, SheetijAide, Pedro Carlos PaulinoCampo, Joseph J.Moncunill Piñas, GemmaDobaño, Carlota, 1969-Vacuna de la malàriaPediatriaAssaigs clínicsMalaria vaccinePediatricsClinical trialsThe RTS,S/AS01 - " vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 clinical trial using a 3-dose immunization schedule. A fourth-dose 18 months after the primary vaccination was shown to restore the waning efficacy. However, only total IgG against the immunodominant malaria vaccine epitope has been analyzed following the booster. To better characterize the magnitude, nature, and longevity of the immune response to the booster, we measured levels of total IgM, IgG, and IgG" - " subclasses against three constructs of the circumsporozoite protein (CSP) and the hepatitis B surface antigen (HBsAg, also present in RTS,S) by quantitative suspension array technology in 50 subjects in the phase 3 trial in Manhi\xC3\xA7a, Mozambique. To explore the impact of vaccination on naturally acquired immune responses, we measured antibodies to " - " antigens not included in RTS,S. We found increased IgG, IgG1, IgG3 and IgG4, but not IgG2 nor IgM, levels against vaccine antigens 1 month after the fourth dose. Overall, antibody responses to the booster dose were lower than the initial peak response to primary immunization and children had higher IgG and IgG1 levels than infants. Higher anti-Rh5 IgG and IgG" - " levels were detected after the booster dose, suggesting that RTS,S partial protection could increase some blood stage antibody responses. Our work shows that the response to the RTS,S/AS01" - " booster dose is different from the primary vaccine immune response and highlights the dynamic changes in subclass antibody patterns upon the vaccine booster and with acquisition of adaptive immunity to malaria."[London] : Springer Nature in partnership with the Sealy Center for Vaccine Development, [2016]-2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/182854Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/ 10.1038/s41541-020-0192-7NPJ vaccines , 2020 , vol. 5 , num. 46http://dx.doi.org/ 10.1038/s41541-020-0192-7cc by (c) Sánchez, Lina et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1828542026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique |
| title |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique |
| spellingShingle |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique Sánchez, Lina Vacuna de la malària Pediatria Assaigs clínics Malaria vaccine Pediatrics Clinical trials |
| title_short |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique |
| title_full |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique |
| title_fullStr |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique |
| title_full_unstemmed |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique |
| title_sort |
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique |
| dc.creator.none.fl_str_mv |
Sánchez, Lina Vidal, Marta Jairoce, Chenjerai Tobias Sixpence Aguilar, Ruth Ubillos, Itziar Cuamba, Inocencia Nhabomba, Augusto J. Williams, Nana Aba Díez Padrisa, Núria Cavanagh, David Angov, Evelina Coppel, Ross L. Gaur, Deepak Beeson, James G. Dutta, Sheetij Aide, Pedro Carlos Paulino Campo, Joseph J. Moncunill Piñas, Gemma Dobaño, Carlota, 1969- |
| author |
Sánchez, Lina |
| author_facet |
Sánchez, Lina Vidal, Marta Jairoce, Chenjerai Tobias Sixpence Aguilar, Ruth Ubillos, Itziar Cuamba, Inocencia Nhabomba, Augusto J. Williams, Nana Aba Díez Padrisa, Núria Cavanagh, David Angov, Evelina Coppel, Ross L. Gaur, Deepak Beeson, James G. Dutta, Sheetij Aide, Pedro Carlos Paulino Campo, Joseph J. Moncunill Piñas, Gemma Dobaño, Carlota, 1969- |
| author_role |
author |
| author2 |
Vidal, Marta Jairoce, Chenjerai Tobias Sixpence Aguilar, Ruth Ubillos, Itziar Cuamba, Inocencia Nhabomba, Augusto J. Williams, Nana Aba Díez Padrisa, Núria Cavanagh, David Angov, Evelina Coppel, Ross L. Gaur, Deepak Beeson, James G. Dutta, Sheetij Aide, Pedro Carlos Paulino Campo, Joseph J. Moncunill Piñas, Gemma Dobaño, Carlota, 1969- |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Vacuna de la malària Pediatria Assaigs clínics Malaria vaccine Pediatrics Clinical trials |
| topic |
Vacuna de la malària Pediatria Assaigs clínics Malaria vaccine Pediatrics Clinical trials |
| description |
The RTS,S/AS01 - " vaccine has shown consistent but partial vaccine efficacy in a pediatric phase 3 clinical trial using a 3-dose immunization schedule. A fourth-dose 18 months after the primary vaccination was shown to restore the waning efficacy. However, only total IgG against the immunodominant malaria vaccine epitope has been analyzed following the booster. To better characterize the magnitude, nature, and longevity of the immune response to the booster, we measured levels of total IgM, IgG, and IgG" - " subclasses against three constructs of the circumsporozoite protein (CSP) and the hepatitis B surface antigen (HBsAg, also present in RTS,S) by quantitative suspension array technology in 50 subjects in the phase 3 trial in Manhi\xC3\xA7a, Mozambique. To explore the impact of vaccination on naturally acquired immune responses, we measured antibodies to " - " antigens not included in RTS,S. We found increased IgG, IgG1, IgG3 and IgG4, but not IgG2 nor IgM, levels against vaccine antigens 1 month after the fourth dose. Overall, antibody responses to the booster dose were lower than the initial peak response to primary immunization and children had higher IgG and IgG1 levels than infants. Higher anti-Rh5 IgG and IgG" - " levels were detected after the booster dose, suggesting that RTS,S partial protection could increase some blood stage antibody responses. Our work shows that the response to the RTS,S/AS01" - " booster dose is different from the primary vaccine immune response and highlights the dynamic changes in subclass antibody patterns upon the vaccine booster and with acquisition of adaptive immunity to malaria." |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/182854 |
| url |
https://hdl.handle.net/2445/182854 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/ 10.1038/s41541-020-0192-7 NPJ vaccines , 2020 , vol. 5 , num. 46 http://dx.doi.org/ 10.1038/s41541-020-0192-7 |
| dc.rights.none.fl_str_mv |
cc by (c) Sánchez, Lina et al., 2020 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by (c) Sánchez, Lina et al., 2020 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
[London] : Springer Nature in partnership with the Sealy Center for Vaccine Development, [2016]- |
| publisher.none.fl_str_mv |
[London] : Springer Nature in partnership with the Sealy Center for Vaccine Development, [2016]- |
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Articles publicats en revistes (ISGlobal) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15,300719 |