Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.

Pronóstíoc en mieloma de pacientes ancianos

Detalles Bibliográficos
Autores: García Sanz, Ramón, González-Fraile, M I, Mateo, G, Hernández, J M, López-Berges, M C, de las Heras, N, Fernández-Calvo, J, Ortega, F, Portero, J A, Bárez, A, Galende, J, Orfao de Matos Correia e Vale, José Alberto, San Miguel, J F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/163045
Acceso en línea:http://hdl.handle.net/10366/163045
Access Level:acceso abierto
Palabra clave:Myeloma
S-Phase
prognosis
elderly
Prognosis
Aged
Multiple Myeloma
Prospective Studies
Risk Factors
Cell Proliferation
3205.04 Hematología
pronóstico
anciano
mieloma múltiple
factores de riesgo
proliferación celular
estudios prospectivos
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spelling Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.García Sanz, RamónGonzález-Fraile, M IMateo, GHernández, J MLópez-Berges, M Cde las Heras, NFernández-Calvo, JOrtega, FPortero, J ABárez, AGalende, JOrfao de Matos Correia e Vale, José AlbertoSan Miguel, J FMyelomaS-PhaseprognosiselderlyPrognosisAgedMultiple MyelomaProspective StudiesRisk FactorsCell Proliferation3205.04 Hematologíapronósticoancianomieloma múltiplefactores de riesgoproliferación celularestudios prospectivosPronóstíoc en mieloma de pacientes ancianos[EN]Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivariate analysis identified 4 factors with independent unfavorable prognostic influence: high percentage of S-phase bone marrow plasma cells (>2.5%); elevated beta(2) microglobulin (B2M) (>4 mg/L); age >80 years old; and LDH serum levels (above normal limit). The S-phase value was the most powerful independent prognostic factor to discriminate subgroups of patients with different prognosis. Thus, 3 main risk categories could be identified according to S-phase values: </=1%, 1-3% and >3%, with median survivals of 34, 22 and 12 months, respectively (p < 0.0001). Our study also proved the value for elderly patients of the recently developed International Score System (ISS) based on B2M and albumin. Furthermore, the number of S-phase cells helped to subdivide the ISS III Group identifying a subset of patients with very poor prognosis defined by an additional high S-phase, who displayed a median survival of only 8 months. These results demonstrate that elderly patients can be accurately classified according to prognosis, which may be particularly valuable when comparing the efficacy of new treatment strategies. Moreover, our results underline the high prognostic value of proliferative activity of PC, a parameter that should be considered in routine laboratory investigations of MM.HUISA USALUSALWiley202520252004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/163045reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglés1;1CC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1630452026-06-07T06:28:51Z
dc.title.none.fl_str_mv Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
title Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
spellingShingle Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
García Sanz, Ramón
Myeloma
S-Phase
prognosis
elderly
Prognosis
Aged
Multiple Myeloma
Prospective Studies
Risk Factors
Cell Proliferation
3205.04 Hematología
pronóstico
anciano
mieloma múltiple
factores de riesgo
proliferación celular
estudios prospectivos
title_short Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
title_full Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
title_fullStr Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
title_full_unstemmed Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
title_sort Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.
dc.creator.none.fl_str_mv García Sanz, Ramón
González-Fraile, M I
Mateo, G
Hernández, J M
López-Berges, M C
de las Heras, N
Fernández-Calvo, J
Ortega, F
Portero, J A
Bárez, A
Galende, J
Orfao de Matos Correia e Vale, José Alberto
San Miguel, J F
author García Sanz, Ramón
author_facet García Sanz, Ramón
González-Fraile, M I
Mateo, G
Hernández, J M
López-Berges, M C
de las Heras, N
Fernández-Calvo, J
Ortega, F
Portero, J A
Bárez, A
Galende, J
Orfao de Matos Correia e Vale, José Alberto
San Miguel, J F
author_role author
author2 González-Fraile, M I
Mateo, G
Hernández, J M
López-Berges, M C
de las Heras, N
Fernández-Calvo, J
Ortega, F
Portero, J A
Bárez, A
Galende, J
Orfao de Matos Correia e Vale, José Alberto
San Miguel, J F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Myeloma
S-Phase
prognosis
elderly
Prognosis
Aged
Multiple Myeloma
Prospective Studies
Risk Factors
Cell Proliferation
3205.04 Hematología
pronóstico
anciano
mieloma múltiple
factores de riesgo
proliferación celular
estudios prospectivos
topic Myeloma
S-Phase
prognosis
elderly
Prognosis
Aged
Multiple Myeloma
Prospective Studies
Risk Factors
Cell Proliferation
3205.04 Hematología
pronóstico
anciano
mieloma múltiple
factores de riesgo
proliferación celular
estudios prospectivos
description Pronóstíoc en mieloma de pacientes ancianos
publishDate 2004
dc.date.none.fl_str_mv 2004
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/163045
url http://hdl.handle.net/10366/163045
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 1;1
dc.rights.none.fl_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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