MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor

BACKGROUND: MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this p...

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Detalhes bibliográficos
Autores: Kuypers, Kim PC, Torre Fornell, Rafael de la, Farré Albaladejo, Magí, Pizarro Lozano, Mª Nieves, Xicota Vila, Laura, 1987-, Ramaekers, Johannes G.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/33717
Acesso em linha:http://hdl.handle.net/10230/33717
http://dx.doi.org/10.1007/s00213-017-4699-1
Access Level:acceso abierto
Palavra-chave:5-HT2A receptor
Arousal
Cognitive bias
Ketanserin
MDMA
Oxytocin
Sound processing
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spelling MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptorKuypers, Kim PCTorre Fornell, Rafael de laFarré Albaladejo, MagíPizarro Lozano, Mª NievesXicota Vila, Laura, 1987-Ramaekers, Johannes G.5-HT2A receptorArousalCognitive biasKetanserinMDMAOxytocinSound processingBACKGROUND: MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this process. In addition, it is, however, unclear what the neurobiological mechanism underlying these MDMA effects on social behaviour is. Previously, studies have shown that MDMA-induced emotional excitability and positive mood are linked to the action on the serotonin (5-HT) 2A receptor. AIM: The present study aimed at investigating the effect of MDMA on processing of sounds (Processing of Affective Sounds Task (PAST)) and cognitive biases (Approach-Avoidance Task (AAT)) towards emotional and social stimuli and the role of 5-HT2A receptor in these effects. METHODS: Twenty healthy recreational users entered a 2 × 2, placebo-controlled, within-subject study with ketanserin (40 mg) as pre-treatment and MDMA (75 mg) as treatment. Behavioural (PAST, AAT) measures were conducted 90 min after treatment with MDMA, respectively, 120 min after ketanserin. Self-report mood measures and oxytocin concentrations were taken at baseline and before and after behavioural tests. RESULTS: Findings showed that MDMA reduced arousal elicited by negative sounds. This effect was counteracted by ketanserin pre-treatment, indicating involvement of the 5-HT2 receptor in this process. MDMA did not seem to induce a bias towards emotional and social stimuli. It increased positive and negative mood ratings and elevated oxytocin plasma concentrations. The reduction in arousal levels when listening to negative sounds was not related to the elevated subjective arousal. CONCLUSION: It is suggested that this decrease in arousal to negative stimuli reflects potentially a lowering of defences, a process that might play a role in the therapeutic process.Springer201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/33717http://dx.doi.org/10.1007/s00213-017-4699-1reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPsychopharmacology (Berl). 2018 Feb;235(2):481-90© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/337172026-05-29T05:05:01Z
dc.title.none.fl_str_mv MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
title MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
spellingShingle MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
Kuypers, Kim PC
5-HT2A receptor
Arousal
Cognitive bias
Ketanserin
MDMA
Oxytocin
Sound processing
title_short MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
title_full MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
title_fullStr MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
title_full_unstemmed MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
title_sort MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
dc.creator.none.fl_str_mv Kuypers, Kim PC
Torre Fornell, Rafael de la
Farré Albaladejo, Magí
Pizarro Lozano, Mª Nieves
Xicota Vila, Laura, 1987-
Ramaekers, Johannes G.
author Kuypers, Kim PC
author_facet Kuypers, Kim PC
Torre Fornell, Rafael de la
Farré Albaladejo, Magí
Pizarro Lozano, Mª Nieves
Xicota Vila, Laura, 1987-
Ramaekers, Johannes G.
author_role author
author2 Torre Fornell, Rafael de la
Farré Albaladejo, Magí
Pizarro Lozano, Mª Nieves
Xicota Vila, Laura, 1987-
Ramaekers, Johannes G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv 5-HT2A receptor
Arousal
Cognitive bias
Ketanserin
MDMA
Oxytocin
Sound processing
topic 5-HT2A receptor
Arousal
Cognitive bias
Ketanserin
MDMA
Oxytocin
Sound processing
description BACKGROUND: MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this process. In addition, it is, however, unclear what the neurobiological mechanism underlying these MDMA effects on social behaviour is. Previously, studies have shown that MDMA-induced emotional excitability and positive mood are linked to the action on the serotonin (5-HT) 2A receptor. AIM: The present study aimed at investigating the effect of MDMA on processing of sounds (Processing of Affective Sounds Task (PAST)) and cognitive biases (Approach-Avoidance Task (AAT)) towards emotional and social stimuli and the role of 5-HT2A receptor in these effects. METHODS: Twenty healthy recreational users entered a 2 × 2, placebo-controlled, within-subject study with ketanserin (40 mg) as pre-treatment and MDMA (75 mg) as treatment. Behavioural (PAST, AAT) measures were conducted 90 min after treatment with MDMA, respectively, 120 min after ketanserin. Self-report mood measures and oxytocin concentrations were taken at baseline and before and after behavioural tests. RESULTS: Findings showed that MDMA reduced arousal elicited by negative sounds. This effect was counteracted by ketanserin pre-treatment, indicating involvement of the 5-HT2 receptor in this process. MDMA did not seem to induce a bias towards emotional and social stimuli. It increased positive and negative mood ratings and elevated oxytocin plasma concentrations. The reduction in arousal levels when listening to negative sounds was not related to the elevated subjective arousal. CONCLUSION: It is suggested that this decrease in arousal to negative stimuli reflects potentially a lowering of defences, a process that might play a role in the therapeutic process.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/33717
http://dx.doi.org/10.1007/s00213-017-4699-1
url http://hdl.handle.net/10230/33717
http://dx.doi.org/10.1007/s00213-017-4699-1
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Psychopharmacology (Berl). 2018 Feb;235(2):481-90
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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