Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis

Artículo con 9 páginas y 2 figuras.

Detalles Bibliográficos
Autores: Sevilla, Lisa M., Pérez, Paloma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/193968
Acceso en línea:http://hdl.handle.net/10261/193968
Access Level:acceso abierto
Palabra clave:Glucocorticoid-induced-leucine-zipper (GILZ/TSC22D3)
Glucocorticoids (GCs)
Immune cells
Keratinocytes
Psoriasis
Signaling
Skin inflammation
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spelling Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in PsoriasisSevilla, Lisa M.Pérez, PalomaGlucocorticoid-induced-leucine-zipper (GILZ/TSC22D3)Glucocorticoids (GCs)Immune cellsKeratinocytesPsoriasisSignalingSkin inflammationArtículo con 9 páginas y 2 figuras.Psoriasis is a prevalent chronic inflammatory human disease initiated by impaired function of immune cells and epidermal keratinocytes, resulting in increased cytokine production and hyperproliferation, leading to skin lesions. Overproduction of Th1- and Th17-cytokines including interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-23, IL-17, and IL-22, is a major driver of the disease. Glucocorticoids (GCs) represent the mainstay protocol for treating psoriasis as they modulate epidermal differentiation and are potent anti-inflammatory compounds. The development of safer GC-based therapies is a high priority due to potentially severe adverse effects associated with prolonged GC use. Specific efforts have focused on downstream anti-inflammatory effectors of GC-signaling such as GC-Induced-Leucine-Zipper (GILZ), which suppresses Th17 responses and antagonizes multiple pro-inflammatory signaling pathways involved in psoriasis, including AP-1, NF-κB, STAT3, and ROR-γt. Here we review evidence regarding defective GC signaling, GC receptor (GR) function, and GILZ in psoriasis. We discuss seemingly contradicting data on the loss- and gain-of-function of GILZ in the imiquimod-induced mouse model of psoriasis. We also present potential therapeutic strategies aimed to restore GC-related pathways.This work was supported by a grant of MINECO, Spanish Government grant SAF2017-88046-R.Peer reviewedFrontiers MediaMinisterio de Economía y Competitividad (España)Pérez, Paloma [0000-0002-7166-2824]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/193968reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-88046-Rhttp://dx.doi.org/10.3389/fimmu.2019.02220Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1939682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
title Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
spellingShingle Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
Sevilla, Lisa M.
Glucocorticoid-induced-leucine-zipper (GILZ/TSC22D3)
Glucocorticoids (GCs)
Immune cells
Keratinocytes
Psoriasis
Signaling
Skin inflammation
title_short Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
title_full Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
title_fullStr Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
title_full_unstemmed Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
title_sort Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis
dc.creator.none.fl_str_mv Sevilla, Lisa M.
Pérez, Paloma
author Sevilla, Lisa M.
author_facet Sevilla, Lisa M.
Pérez, Paloma
author_role author
author2 Pérez, Paloma
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Pérez, Paloma [0000-0002-7166-2824]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Glucocorticoid-induced-leucine-zipper (GILZ/TSC22D3)
Glucocorticoids (GCs)
Immune cells
Keratinocytes
Psoriasis
Signaling
Skin inflammation
topic Glucocorticoid-induced-leucine-zipper (GILZ/TSC22D3)
Glucocorticoids (GCs)
Immune cells
Keratinocytes
Psoriasis
Signaling
Skin inflammation
description Artículo con 9 páginas y 2 figuras.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/193968
url http://hdl.handle.net/10261/193968
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-88046-R
http://dx.doi.org/10.3389/fimmu.2019.02220
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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