Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma

Adrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes. Loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1) cause primary adrenal insufficiency and as a key degradative enzyme in the...

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Detalhes bibliográficos
Autores: Williams, Jack L., Smith, Chris, Hall, Charlotte, Khaled, Zakaa, Maharaj, Avinaash, Kwong, Ruth, Pittaway, James, Casas, Josefina, Parvanta, Laila, Abdel-Aziz, Tarek Ezzat, Palazzo, Fausto, Chung, Teng-Teng, Guasti, Leonardo, Metherell, Lou, Prasad, Rathi
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/287870
Acesso em linha:http://hdl.handle.net/10261/287870
https://api.elsevier.com/content/abstract/scopus_id/85146412492
Access Level:Acceso aberto
Palavra-chave:Sphingosine-1-phosphate lyase
SGPL1
Adrenocortical carcinoma
Sphingolipids
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spelling Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinomaWilliams, Jack L.Smith, ChrisHall, CharlotteKhaled, ZakaaMaharaj, AvinaashKwong, RuthPittaway, JamesCasas, JosefinaParvanta, LailaAbdel-Aziz, Tarek EzzatPalazzo, FaustoChung, Teng-TengGuasti, LeonardoMetherell, LouPrasad, RathiSphingosine-1-phosphate lyaseSGPL1Adrenocortical carcinomaSphingolipidsAdrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes. Loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1) cause primary adrenal insufficiency and as a key degradative enzyme in the sphingolipid pathway, SGPL1 also influences the balance of pro-proliferative and pro-apoptotic sphingolipids. We, therefore, hypothesized increased SGPL1 may be linked to increased disease severity in ACC.This work was supported by Barts Charity grants MGU0361 to L.M. and R.P.; MGU0438 to L.M.; MGU0528 to R.K.; MGU0436 to L.G.; Government of Trinidad and Tobago Research Fellowship to A.M.; Medical Research Council (MRC) UK Clinical Academic Research Partner grant (MR/T02402X/1) to R.P. and MRC clinical research fellowships (MR/S022155/1) to J.P. and (MR/W015935/1) to R.K.Peer reviewedOxford University PressWilliams, Jack L. [0000-0002-1289-6671]Metherell, Lou [0000-0002-0530-3524]Prasad, Rathi [0000-0001-6360-7246]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/287870https://api.elsevier.com/content/abstract/scopus_id/85146412492reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésEuropean journal of endocrinologyhttps://doi.org/10.1093/ejendo/lvac007Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2878702026-05-22T06:33:51Z
dc.title.none.fl_str_mv Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
title Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
spellingShingle Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
Williams, Jack L.
Sphingosine-1-phosphate lyase
SGPL1
Adrenocortical carcinoma
Sphingolipids
title_short Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
title_full Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
title_fullStr Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
title_full_unstemmed Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
title_sort Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
dc.creator.none.fl_str_mv Williams, Jack L.
Smith, Chris
Hall, Charlotte
Khaled, Zakaa
Maharaj, Avinaash
Kwong, Ruth
Pittaway, James
Casas, Josefina
Parvanta, Laila
Abdel-Aziz, Tarek Ezzat
Palazzo, Fausto
Chung, Teng-Teng
Guasti, Leonardo
Metherell, Lou
Prasad, Rathi
author Williams, Jack L.
author_facet Williams, Jack L.
Smith, Chris
Hall, Charlotte
Khaled, Zakaa
Maharaj, Avinaash
Kwong, Ruth
Pittaway, James
Casas, Josefina
Parvanta, Laila
Abdel-Aziz, Tarek Ezzat
Palazzo, Fausto
Chung, Teng-Teng
Guasti, Leonardo
Metherell, Lou
Prasad, Rathi
author_role author
author2 Smith, Chris
Hall, Charlotte
Khaled, Zakaa
Maharaj, Avinaash
Kwong, Ruth
Pittaway, James
Casas, Josefina
Parvanta, Laila
Abdel-Aziz, Tarek Ezzat
Palazzo, Fausto
Chung, Teng-Teng
Guasti, Leonardo
Metherell, Lou
Prasad, Rathi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Williams, Jack L. [0000-0002-1289-6671]
Metherell, Lou [0000-0002-0530-3524]
Prasad, Rathi [0000-0001-6360-7246]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Sphingosine-1-phosphate lyase
SGPL1
Adrenocortical carcinoma
Sphingolipids
topic Sphingosine-1-phosphate lyase
SGPL1
Adrenocortical carcinoma
Sphingolipids
description Adrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes. Loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1) cause primary adrenal insufficiency and as a key degradative enzyme in the sphingolipid pathway, SGPL1 also influences the balance of pro-proliferative and pro-apoptotic sphingolipids. We, therefore, hypothesized increased SGPL1 may be linked to increased disease severity in ACC.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/287870
https://api.elsevier.com/content/abstract/scopus_id/85146412492
url http://hdl.handle.net/10261/287870
https://api.elsevier.com/content/abstract/scopus_id/85146412492
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European journal of endocrinology
https://doi.org/10.1093/ejendo/lvac007
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422046274912256
score 15.811543

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