Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs

Hernández-Banqué, Carles|||0000-0003-4962-0086; Liu, Junhui|||0000-0002-2293-5814; Jové-Juncà, Teodor|||0000-0002-6436-3279; González-Rodríguez, Olga; Portero-Otín, Manuel|||0000-0002-1823-0299; Folch, Josep M.|||0000-0003-3689-1303; Quintanilla, Raquel|||0000-0003-3274-3434; Ballester Devis, Maria|||0000-0002-5413-4640

Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs

Fatty acids are a diverse group of lipid molecules that play essential roles in energy metabolism, cellular differentiation and signalling mechanisms. The objective of this study was to explore the genetic determinism of fatty acid composition across backfat, liver, muscle and plasma and its associa...

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Autores:	Hernández-Banqué, Carles\|\|\|0000-0003-4962-0086, Liu, Junhui\|\|\|0000-0002-2293-5814, Jové-Juncà, Teodor\|\|\|0000-0002-6436-3279, González-Rodríguez, Olga, Portero-Otín, Manuel\|\|\|0000-0002-1823-0299, Folch, Josep M.\|\|\|0000-0003-3689-1303, Quintanilla, Raquel\|\|\|0000-0003-3274-3434, Ballester Devis, Maria\|\|\|0000-0002-5413-4640
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:dnet:uabarcelona_::441146f49065ad6107e0d2816ac47586
Acceso en línea:	https://ddd.uab.cat/record/327871 https://dx.doi.org/urn:doi:10.1038/s41598-025-27713-3
Access Level:	acceso abierto
Palabra clave:	Fatty acid profiles Heritability Genetic correlations Immunity Pig Animal breeding Genetic association study Fatty acids

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spelling	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigsHernández-Banqué, Carles\|\|\|0000-0003-4962-0086Liu, Junhui\|\|\|0000-0002-2293-5814Jové-Juncà, Teodor\|\|\|0000-0002-6436-3279González-Rodríguez, OlgaPortero-Otín, Manuel\|\|\|0000-0002-1823-0299Folch, Josep M.\|\|\|0000-0003-3689-1303Quintanilla, Raquel\|\|\|0000-0003-3274-3434Ballester Devis, Maria\|\|\|0000-0002-5413-4640Fatty acid profilesHeritabilityGenetic correlationsImmunityPigAnimal breedingGenetic association studyFatty acidsFatty acids are a diverse group of lipid molecules that play essential roles in energy metabolism, cellular differentiation and signalling mechanisms. The objective of this study was to explore the genetic determinism of fatty acid composition across backfat, liver, muscle and plasma and its association with immunocompetence and performance traits in pigs. Fatty acid profiles were analysed in 432 commercial Duroc pigs. High heritability was found for most fatty acids in backfat and for long-chain polyunsaturated fatty acids in liver, while muscle and plasma showed medium to low heritabilities. Strong genetic correlations were observed between the relative abundance of γδ T cells and cytotoxic T cells with the lipid profiles of backfat and muscle, with opposite patterns between these cell types. Muscle unsaturated fatty acids were positively correlated with phagocytosis capacity and red blood cell traits, and negatively with plasma cortisol. Acute phase proteins showed similar correlations with liver lipids but opposite with some plasma fatty acids. Lean meat and fatness traits were particularly associated to the backfat fatty acid composition, showing opposite correlation patterns, while pH was strongly correlated with the liver fatty acid profile. These results demonstrated the specific lipid profiles of backfat, liver, muscle and plasma, their genetic determinism, and their relationships with immunity and production traits. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/327871https://dx.doi.org/urn:doi:10.1038/s41598-025-27713-3reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 PID2023-148961OB-C21Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-112677RB-C21Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PRE2021-097825Generalitat de Catalunya https://doi.org/10.13039/501100002809 2021-SGR-01552open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::441146f49065ad6107e0d2816ac475862026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
spellingShingle	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs Hernández-Banqué, Carles\|\|\|0000-0003-4962-0086 Fatty acid profiles Heritability Genetic correlations Immunity Pig Animal breeding Genetic association study Fatty acids
title_short	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_full	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_fullStr	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_full_unstemmed	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_sort	Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
dc.creator.none.fl_str_mv	Hernández-Banqué, Carles\|\|\|0000-0003-4962-0086 Liu, Junhui\|\|\|0000-0002-2293-5814 Jové-Juncà, Teodor\|\|\|0000-0002-6436-3279 González-Rodríguez, Olga Portero-Otín, Manuel\|\|\|0000-0002-1823-0299 Folch, Josep M.\|\|\|0000-0003-3689-1303 Quintanilla, Raquel\|\|\|0000-0003-3274-3434 Ballester Devis, Maria\|\|\|0000-0002-5413-4640
author	Hernández-Banqué, Carles\|\|\|0000-0003-4962-0086
author_facet	Hernández-Banqué, Carles\|\|\|0000-0003-4962-0086 Liu, Junhui\|\|\|0000-0002-2293-5814 Jové-Juncà, Teodor\|\|\|0000-0002-6436-3279 González-Rodríguez, Olga Portero-Otín, Manuel\|\|\|0000-0002-1823-0299 Folch, Josep M.\|\|\|0000-0003-3689-1303 Quintanilla, Raquel\|\|\|0000-0003-3274-3434 Ballester Devis, Maria\|\|\|0000-0002-5413-4640
author_role	author
author2	Liu, Junhui\|\|\|0000-0002-2293-5814 Jové-Juncà, Teodor\|\|\|0000-0002-6436-3279 González-Rodríguez, Olga Portero-Otín, Manuel\|\|\|0000-0002-1823-0299 Folch, Josep M.\|\|\|0000-0003-3689-1303 Quintanilla, Raquel\|\|\|0000-0003-3274-3434 Ballester Devis, Maria\|\|\|0000-0002-5413-4640
author2_role	author author author author author author author
dc.subject.none.fl_str_mv	Fatty acid profiles Heritability Genetic correlations Immunity Pig Animal breeding Genetic association study Fatty acids
topic	Fatty acid profiles Heritability Genetic correlations Immunity Pig Animal breeding Genetic association study Fatty acids
description	Fatty acids are a diverse group of lipid molecules that play essential roles in energy metabolism, cellular differentiation and signalling mechanisms. The objective of this study was to explore the genetic determinism of fatty acid composition across backfat, liver, muscle and plasma and its association with immunocompetence and performance traits in pigs. Fatty acid profiles were analysed in 432 commercial Duroc pigs. High heritability was found for most fatty acids in backfat and for long-chain polyunsaturated fatty acids in liver, while muscle and plasma showed medium to low heritabilities. Strong genetic correlations were observed between the relative abundance of γδ T cells and cytotoxic T cells with the lipid profiles of backfat and muscle, with opposite patterns between these cell types. Muscle unsaturated fatty acids were positively correlated with phagocytosis capacity and red blood cell traits, and negatively with plasma cortisol. Acute phase proteins showed similar correlations with liver lipids but opposite with some plasma fatty acids. Lean meat and fatness traits were particularly associated to the backfat fatty acid composition, showing opposite correlation patterns, while pH was strongly correlated with the liver fatty acid profile. These results demonstrated the specific lipid profiles of backfat, liver, muscle and plasma, their genetic determinism, and their relationships with immunity and production traits.
publishDate	2025
dc.date.none.fl_str_mv	2 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/327871 https://dx.doi.org/urn:doi:10.1038/s41598-025-27713-3
url	https://ddd.uab.cat/record/327871 https://dx.doi.org/urn:doi:10.1038/s41598-025-27713-3
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Ministerio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 PID2023-148961OB-C21 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-112677RB-C21 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PRE2021-097825 Generalitat de Catalunya https://doi.org/10.13039/501100002809 2021-SGR-01552
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs

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