Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering

In tissue engineering the design and optimization of biodegradable polymeric scaffolds with a 3D-structure is an important field. The porous scaffold provide the cells with an adequate biomechanical environment that allows mechanotransduction signals for cell differentiation and the scaffolds also p...

ver descrição completa

Detalhes bibliográficos
Autores: Vikingsson, Line Karina Alva, Claessens, B., Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829, Gallego-Ferrer, Gloria|||0000-0002-2428-0903, Gómez Ribelles, José Luís|||0000-0001-9099-0885
Tipo de documento: artigo
Data de publicação:2015
País:España
Recursos:Universitat Politècnica de València (UPV)
Repositório:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglês
OAI Identifier:oai:riunet.upv.es:10251/63634
Acesso em linha:https://riunet.upv.es/handle/10251/63634
Access Level:Acceso aberto
Palavra-chave:Porous scaffolds
Permeability
Polycaprolactone
Poly (vinyl alcohol)
Freezing and thawing
Mechanical properties
id ES_df2bfcba69271455df70d72cd3550a1a
oai_identifier_str oai:riunet.upv.es:10251/63634
network_acronym_str ES
network_name_str España
repository_id_str
spelling Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineeringVikingsson, Line Karina AlvaClaessens, B.Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829Gallego-Ferrer, Gloria|||0000-0002-2428-0903Gómez Ribelles, José Luís|||0000-0001-9099-0885Porous scaffoldsPermeabilityPolycaprolactonePoly (vinyl alcohol)Freezing and thawingMechanical propertiesIn tissue engineering the design and optimization of biodegradable polymeric scaffolds with a 3D-structure is an important field. The porous scaffold provide the cells with an adequate biomechanical environment that allows mechanotransduction signals for cell differentiation and the scaffolds also protect the cells from initial compressive loading. The scaffold have interconnected macro-pores that host the cells and newly formed tissue, while the pore walls should be micro-porous to transport nutrients and waste products. Polycaprolactone (PCL) scaffolds with a double micro- and macro-pore architecture have been proposed for cartilage regeneration. This work explores the influence of the micro-porosity of the pore walls on water permeability and scaffold compliance. A Poly(Vinyl Alcohol) with tailored mechanical properties has been used to simulate the growing cartilage tissue inside the scaffold pores. Unconfined and confined compression tests were performed to characterize both the water permeability and the mechanical response of scaffolds with varying size of micro-porosity while volume fraction of the macro-pores remains constant. The stress relaxation tests show that the stress response of the scaffold/ hydrogel construct is a synergic effect determined by the performance of the both components. This is interesting since it suggests that the in vivo outcome of the scaffold is not only dependent upon the material architecture but also the growing tissue inside the scaffold's pores. On the other hand, confined compression results show that compliance of the scaffold is mainly controlled by the micro-porosity of the scaffold and less by hydrogel density in the scaffold pores. These conclusions bring together valuable information for customizing the optimal scaffold and to predict the in vivo mechanical behavior.The authors gratefully acknowledge the financial support from the Spanish Ministry of Economy and Competitiveness through the MAT2013-46467-C4-1-R project, including FEDER funds. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with the assistance from the European Regional Development Fund.ElsevierDepartamento de Física AplicadaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de Termodinámica AplicadaEscuela Técnica Superior de Ingeniería Geodésica, Cartográfica y TopográficaCentro de Biomateriales e Ingeniería TisularEscuela Técnica Superior de Ingeniería IndustrialMinisterio de Economía y CompetitividadMinisterio de Ciencia e InnovaciónEuropean Regional Development FundInstituto de Salud Carlos IIIRepositorio Institucional de la Universitat Politècnica de València Riunet20152015-08-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/63634reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-1-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVAopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/636342026-06-13T07:49:27Z
dc.title.none.fl_str_mv Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
title Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
spellingShingle Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
Vikingsson, Line Karina Alva
Porous scaffolds
Permeability
Polycaprolactone
Poly (vinyl alcohol)
Freezing and thawing
Mechanical properties
title_short Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
title_full Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
title_fullStr Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
title_full_unstemmed Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
title_sort Relationship between micro-porosity, water permeability and mechanical behavior in scaffolds for cartilage engineering
dc.creator.none.fl_str_mv Vikingsson, Line Karina Alva
Claessens, B.
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author Vikingsson, Line Karina Alva
author_facet Vikingsson, Line Karina Alva
Claessens, B.
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author_role author
author2 Claessens, B.
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Física Aplicada
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Termodinámica Aplicada
Escuela Técnica Superior de Ingeniería Geodésica, Cartográfica y Topográfica
Centro de Biomateriales e Ingeniería Tisular
Escuela Técnica Superior de Ingeniería Industrial
Ministerio de Economía y Competitividad
Ministerio de Ciencia e Innovación
European Regional Development Fund
Instituto de Salud Carlos III
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Porous scaffolds
Permeability
Polycaprolactone
Poly (vinyl alcohol)
Freezing and thawing
Mechanical properties
topic Porous scaffolds
Permeability
Polycaprolactone
Poly (vinyl alcohol)
Freezing and thawing
Mechanical properties
description In tissue engineering the design and optimization of biodegradable polymeric scaffolds with a 3D-structure is an important field. The porous scaffold provide the cells with an adequate biomechanical environment that allows mechanotransduction signals for cell differentiation and the scaffolds also protect the cells from initial compressive loading. The scaffold have interconnected macro-pores that host the cells and newly formed tissue, while the pore walls should be micro-porous to transport nutrients and waste products. Polycaprolactone (PCL) scaffolds with a double micro- and macro-pore architecture have been proposed for cartilage regeneration. This work explores the influence of the micro-porosity of the pore walls on water permeability and scaffold compliance. A Poly(Vinyl Alcohol) with tailored mechanical properties has been used to simulate the growing cartilage tissue inside the scaffold pores. Unconfined and confined compression tests were performed to characterize both the water permeability and the mechanical response of scaffolds with varying size of micro-porosity while volume fraction of the macro-pores remains constant. The stress relaxation tests show that the stress response of the scaffold/ hydrogel construct is a synergic effect determined by the performance of the both components. This is interesting since it suggests that the in vivo outcome of the scaffold is not only dependent upon the material architecture but also the growing tissue inside the scaffold's pores. On the other hand, confined compression results show that compliance of the scaffold is mainly controlled by the micro-porosity of the scaffold and less by hydrogel density in the scaffold pores. These conclusions bring together valuable information for customizing the optimal scaffold and to predict the in vivo mechanical behavior.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-08-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/63634
url https://riunet.upv.es/handle/10251/63634
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-1-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422040371429376
score 15,300719

Registros relacionados