Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient

Tissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familial atrial fibrillation by nucleofection of non-integrating epi...

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Autores: Martínez Moreno, Rebecca, Pérez Serra, Alexandra, Selga, Elisabet, Carreras, David, Aran, Begoña, Kuebler, Bernd, Scornik, Fabiana S., Pérez, Guillermo J., Brugada, Ramon
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universidad de Oviedo (UNIOVI)
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/224973
Acesso em linha:https://hdl.handle.net/2445/224973
Access Level:acceso abierto
Palavra-chave:Epigènesi
Patologia cel·lular
Cèl·lules mare embrionàries
Epigenesis
Cellular pathology
Embryonic stem cells
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spelling Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patientMartínez Moreno, RebeccaPérez Serra, AlexandraSelga, ElisabetCarreras, DavidAran, BegoñaKuebler, BerndScornik, Fabiana S.Pérez, Guillermo J.Brugada, RamonEpigènesiPatologia cel·lularCèl·lules mare embrionàriesEpigenesisCellular pathologyEmbryonic stem cellsTissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familial atrial fibrillation by nucleofection of non-integrating episomal vectors. The resulting hiPSC line displays a normal karyotype, expresses pluripotency surface markers and pluripotency genes, and differentiates into cells of the 3 germ layers. Therefore, it represents a reliable model to study the disease in a physiologically relevant cellular environment.Elsevier BV2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/224973Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de Oviedo (UNIOVI)InglésReproducció del document publicat a: https://doi.org/10.1016/j.scr.2023.103239Stem Cell Research, 2023, vol. 73https://doi.org/10.1016/j.scr.2023.103239cc-by (c) Martínez Moreno, Rebecca et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2249732026-05-27T06:46:51Z
dc.title.none.fl_str_mv Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
title Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
spellingShingle Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
Martínez Moreno, Rebecca
Epigènesi
Patologia cel·lular
Cèl·lules mare embrionàries
Epigenesis
Cellular pathology
Embryonic stem cells
title_short Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
title_full Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
title_fullStr Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
title_full_unstemmed Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
title_sort Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
dc.creator.none.fl_str_mv Martínez Moreno, Rebecca
Pérez Serra, Alexandra
Selga, Elisabet
Carreras, David
Aran, Begoña
Kuebler, Bernd
Scornik, Fabiana S.
Pérez, Guillermo J.
Brugada, Ramon
author Martínez Moreno, Rebecca
author_facet Martínez Moreno, Rebecca
Pérez Serra, Alexandra
Selga, Elisabet
Carreras, David
Aran, Begoña
Kuebler, Bernd
Scornik, Fabiana S.
Pérez, Guillermo J.
Brugada, Ramon
author_role author
author2 Pérez Serra, Alexandra
Selga, Elisabet
Carreras, David
Aran, Begoña
Kuebler, Bernd
Scornik, Fabiana S.
Pérez, Guillermo J.
Brugada, Ramon
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epigènesi
Patologia cel·lular
Cèl·lules mare embrionàries
Epigenesis
Cellular pathology
Embryonic stem cells
topic Epigènesi
Patologia cel·lular
Cèl·lules mare embrionàries
Epigenesis
Cellular pathology
Embryonic stem cells
description Tissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familial atrial fibrillation by nucleofection of non-integrating episomal vectors. The resulting hiPSC line displays a normal karyotype, expresses pluripotency surface markers and pluripotency genes, and differentiates into cells of the 3 germ layers. Therefore, it represents a reliable model to study the disease in a physiologically relevant cellular environment.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/224973
url https://hdl.handle.net/2445/224973
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.scr.2023.103239
Stem Cell Research, 2023, vol. 73
https://doi.org/10.1016/j.scr.2023.103239
dc.rights.none.fl_str_mv cc-by (c) Martínez Moreno, Rebecca et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Martínez Moreno, Rebecca et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Oviedo (UNIOVI)
instname_str Universidad de Oviedo (UNIOVI)
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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