Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol

The main objectives of the present study were to determine the effects of presynchronizing with a 1.0 g intravaginal progesterone device (IVPD) and prostaglandin F2α and to assess the effects of re-utilization of IVPD in a 2x2 factorial design, on the ovulatory response to first GnRH, ovarian status...

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Autores: Flores, T., Sánchez, J.M., López-Helguera, Irene, Rojas Cañadas, Eber
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/467494
Acceso en línea:https://doi.org/10.1016/j.theriogenology.2024.12.010
https://hdl.handle.net/10459.1/467494
Access Level:acceso abierto
Palabra clave:Cattle
Estrus expression
Gonadotropin releasing hormone
Ovulation
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spelling Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocolFlores, T.Sánchez, J.M.López-Helguera, IreneRojas Cañadas, EberCattleEstrus expressionGonadotropin releasing hormoneOvulationThe main objectives of the present study were to determine the effects of presynchronizing with a 1.0 g intravaginal progesterone device (IVPD) and prostaglandin F2α and to assess the effects of re-utilization of IVPD in a 2x2 factorial design, on the ovulatory response to first GnRH, ovarian status at different protocol stages, estrus expression and fertility in beef heifers submitted to a 5d-CO-Synch + Progesterone (P4) protocol. Beef heifers (n = 564) were assigned to 1 of 2 treatments at D-15: Pres5 (n = 283), where heifers received a (IVPD) for 5 days and administration of prostaglandin F2α (25 mg of dinoprost) at D-10; and Control (n = 281), where heifers received no treatment. At D-8, all heifers received 100 μg of GnRH (gonadorelin acetate) and were assigned to 1 of 2 IVPD-use treatments: new-IVPD (n = 279), where animals received a new IVPD for 5 days, and once-used IVPD (n = 285), where heifers received a once-used IVPD for 5 days (used previously for 5 days). On D-3, IVPD was removed and 50 mg of prostaglandin F2α was administered. All heifers were timed artificially inseminated (AI; D0) 62 h after IVPD removal concomitant with an administration of 100 μg of GnRH. Estrus detection patches were placed on heifers at D-3 and evaluated at the time of AI. In a subset of heifers (n = 278), transrectal ultrasonography of the ovaries was carried out at D-8 and D-3 to assess presence and diameter of CL and largest follicle diameter (LFD). A blood sample was collected on D-3 to determine serum P4 concentration. Heifers with a once-used IVPD had a greater (P = 0.01) pregnancy per AI (P/AI) than heifers treated with a new-IVPD [62.8 % (179/285) vs 51.2 % (143/279)]. There was a lower percentage of animals (P = 0.002) having a corpus luteum (CL) on D-8 in Pres5 group compared to Control [16.4 % (22/134) vs 69.4 % (100/144)]. Similarly, a greater percentage of Pres5 heifers had a dominant follicle on D-8 (P < 0.0001) than Control heifers [97.7 % (131/134) vs 75.7 % (109/144)]. At D-3, Pres5 heifers had a greater ovulatory response to D-8 GnRH (P < 0.0001) compared to Control animals [82.8 % (111/134) vs 49.3 % (71/144)]. In addition, Pres5 heifers had a greater estrus expression behavior [87.6 % (248/283) vs 72.9 % (205/281); P < 0.0001] and tended to have (P = 0.10) a greater P/AI [61.8 % (175/283) vs 52.3 % (147/281)] than Control heifers. In conclusion, the tendency for a greater fertility observed in Pres5 heifers (∼10 %) justifies the extra animal handling required for presynchronization. A once-used IVPD represents a viable strategy to enhance P/AI and reduce the cost in beef heifers submitted to timed AI.Elsevier2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1016/j.theriogenology.2024.12.010https://hdl.handle.net/10459.1/467494reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.1016/j.theriogenology.2024.12.010Theriogenology, 2025, vol. 234, p. 117-124cc-by (c) Flores et al., 2025Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4674942026-06-24T12:42:17Z
dc.title.none.fl_str_mv Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
title Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
spellingShingle Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
Flores, T.
Cattle
Estrus expression
Gonadotropin releasing hormone
Ovulation
title_short Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
title_full Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
title_fullStr Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
title_full_unstemmed Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
title_sort Presynchronization with a progesterone device and prostaglandin F2α enhances ovulatory response to first GnRH, estrus expression and tended to increase fertility in beef heifers submitted to a 5-day CO-Synch protocol
dc.creator.none.fl_str_mv Flores, T.
Sánchez, J.M.
López-Helguera, Irene
Rojas Cañadas, Eber
author Flores, T.
author_facet Flores, T.
Sánchez, J.M.
López-Helguera, Irene
Rojas Cañadas, Eber
author_role author
author2 Sánchez, J.M.
López-Helguera, Irene
Rojas Cañadas, Eber
author2_role author
author
author
dc.subject.none.fl_str_mv Cattle
Estrus expression
Gonadotropin releasing hormone
Ovulation
topic Cattle
Estrus expression
Gonadotropin releasing hormone
Ovulation
description The main objectives of the present study were to determine the effects of presynchronizing with a 1.0 g intravaginal progesterone device (IVPD) and prostaglandin F2α and to assess the effects of re-utilization of IVPD in a 2x2 factorial design, on the ovulatory response to first GnRH, ovarian status at different protocol stages, estrus expression and fertility in beef heifers submitted to a 5d-CO-Synch + Progesterone (P4) protocol. Beef heifers (n = 564) were assigned to 1 of 2 treatments at D-15: Pres5 (n = 283), where heifers received a (IVPD) for 5 days and administration of prostaglandin F2α (25 mg of dinoprost) at D-10; and Control (n = 281), where heifers received no treatment. At D-8, all heifers received 100 μg of GnRH (gonadorelin acetate) and were assigned to 1 of 2 IVPD-use treatments: new-IVPD (n = 279), where animals received a new IVPD for 5 days, and once-used IVPD (n = 285), where heifers received a once-used IVPD for 5 days (used previously for 5 days). On D-3, IVPD was removed and 50 mg of prostaglandin F2α was administered. All heifers were timed artificially inseminated (AI; D0) 62 h after IVPD removal concomitant with an administration of 100 μg of GnRH. Estrus detection patches were placed on heifers at D-3 and evaluated at the time of AI. In a subset of heifers (n = 278), transrectal ultrasonography of the ovaries was carried out at D-8 and D-3 to assess presence and diameter of CL and largest follicle diameter (LFD). A blood sample was collected on D-3 to determine serum P4 concentration. Heifers with a once-used IVPD had a greater (P = 0.01) pregnancy per AI (P/AI) than heifers treated with a new-IVPD [62.8 % (179/285) vs 51.2 % (143/279)]. There was a lower percentage of animals (P = 0.002) having a corpus luteum (CL) on D-8 in Pres5 group compared to Control [16.4 % (22/134) vs 69.4 % (100/144)]. Similarly, a greater percentage of Pres5 heifers had a dominant follicle on D-8 (P < 0.0001) than Control heifers [97.7 % (131/134) vs 75.7 % (109/144)]. At D-3, Pres5 heifers had a greater ovulatory response to D-8 GnRH (P < 0.0001) compared to Control animals [82.8 % (111/134) vs 49.3 % (71/144)]. In addition, Pres5 heifers had a greater estrus expression behavior [87.6 % (248/283) vs 72.9 % (205/281); P < 0.0001] and tended to have (P = 0.10) a greater P/AI [61.8 % (175/283) vs 52.3 % (147/281)] than Control heifers. In conclusion, the tendency for a greater fertility observed in Pres5 heifers (∼10 %) justifies the extra animal handling required for presynchronization. A once-used IVPD represents a viable strategy to enhance P/AI and reduce the cost in beef heifers submitted to timed AI.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.theriogenology.2024.12.010
https://hdl.handle.net/10459.1/467494
url https://doi.org/10.1016/j.theriogenology.2024.12.010
https://hdl.handle.net/10459.1/467494
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1016/j.theriogenology.2024.12.010
Theriogenology, 2025, vol. 234, p. 117-124
dc.rights.none.fl_str_mv cc-by (c) Flores et al., 2025
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Flores et al., 2025
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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