Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD

INTRODUCTION: Abnormalities of autonomic function have been reported in patients with chronic obstructive pulmonary disease (COPD). Our objectives were to identify determinants of abnormal heart rate recovery at 1 min (HRR1) following completion of the 6-min walk test (6MWT) in COPD and to establish...

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Autores: Rodríguez Chiaradia, Diego Agustín, Kortianou, Eleni A., Alison, Jennifer A., Casas, Alejandro, Giavedoni, Santiago, Barberan-Garcia, Anael, Arbillaga Etxarri, Ane, 1986-, Vilaró, Jordi, Gimeno Santos, Elena, 1980-, Vogiatzis, Ioannis, Rabinovich, Roberto A., Roca Torrent, Josep
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/34966
Acesso em linha:http://hdl.handle.net/10230/34966
http://dx.doi.org/10.1007/s00408-017-0027-0
Access Level:Acceso aberto
Palavra-chave:Marcadors bioquímics
Pulmons--Malalties obstructives
Exercici
Biomarker
COPD
Exercise
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spelling Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPDRodríguez Chiaradia, Diego AgustínKortianou, Eleni A.Alison, Jennifer A.Casas, AlejandroGiavedoni, SantiagoBarberan-Garcia, AnaelArbillaga Etxarri, Ane, 1986-Vilaró, JordiGimeno Santos, Elena, 1980-Vogiatzis, IoannisRabinovich, Roberto A.Roca Torrent, JosepMarcadors bioquímicsPulmons--Malalties obstructivesExerciciBiomarkerCOPDExerciseINTRODUCTION: Abnormalities of autonomic function have been reported in patients with chronic obstructive pulmonary disease (COPD). Our objectives were to identify determinants of abnormal heart rate recovery at 1 min (HRR1) following completion of the 6-min walk test (6MWT) in COPD and to establish whether abnormal HRR1 predicts acute exacerbations (AECOPD). METHODS: Hundred one COPD patients (FEV1 (SD) 53 (19) % predicted) were prospectively recruited in a multi-center study. HRR1 after the 6MWT was evaluated as the difference between heart rate at the end of the test and 1 min into the recovery (HRR1). Linear and logistic regression was used to identify predictors of HRR1 and AECOPD, respectively. The best HRR1 cut-off point to predict AECOPD was selected using the receiver operating characteristics (ROC) curves. The follow-up period was 12 months. RESULTS: Distance covered during the 6MWT (m) and DLco (% predicted) were independently associated with HRR1 (r 2 = 0.51, p = 0.001). Among several potential covariates, HRR1 emerged as the most significant predictor of AECOPD (Odds ratio [OR], 0.91 per beat of recovery; 95% confidence interval [CI], 0.85-0.97; p = 0.02). The ROC analysis indicated that subjects with HRR1 less than 14 beats (AUC, 0.71 [CI] 0.60-0.80; p = 0.0001) were more likely to suffer an exacerbation during the follow-up period (for HRR1, p = 0.004 [log-rank test]). CONCLUSIONS: HRR1 after the 6MWT is an independent predictor factor for AECOPD. Further studies are warranted to examine the physiological mechanisms associating a delayed HRR and acute exacerbations in COPD patients.Springer201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34966http://dx.doi.org/10.1007/s00408-017-0027-0reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésLung. 2017 Aug;195(4):463-7© Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00408-017-0027-0info:eu-repo/semantics/openAccessoai:recercat.cat:10230/349662026-05-29T05:05:01Z
dc.title.none.fl_str_mv Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
title Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
spellingShingle Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
Rodríguez Chiaradia, Diego Agustín
Marcadors bioquímics
Pulmons--Malalties obstructives
Exercici
Biomarker
COPD
Exercise
title_short Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
title_full Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
title_fullStr Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
title_full_unstemmed Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
title_sort Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
dc.creator.none.fl_str_mv Rodríguez Chiaradia, Diego Agustín
Kortianou, Eleni A.
Alison, Jennifer A.
Casas, Alejandro
Giavedoni, Santiago
Barberan-Garcia, Anael
Arbillaga Etxarri, Ane, 1986-
Vilaró, Jordi
Gimeno Santos, Elena, 1980-
Vogiatzis, Ioannis
Rabinovich, Roberto A.
Roca Torrent, Josep
author Rodríguez Chiaradia, Diego Agustín
author_facet Rodríguez Chiaradia, Diego Agustín
Kortianou, Eleni A.
Alison, Jennifer A.
Casas, Alejandro
Giavedoni, Santiago
Barberan-Garcia, Anael
Arbillaga Etxarri, Ane, 1986-
Vilaró, Jordi
Gimeno Santos, Elena, 1980-
Vogiatzis, Ioannis
Rabinovich, Roberto A.
Roca Torrent, Josep
author_role author
author2 Kortianou, Eleni A.
Alison, Jennifer A.
Casas, Alejandro
Giavedoni, Santiago
Barberan-Garcia, Anael
Arbillaga Etxarri, Ane, 1986-
Vilaró, Jordi
Gimeno Santos, Elena, 1980-
Vogiatzis, Ioannis
Rabinovich, Roberto A.
Roca Torrent, Josep
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Pulmons--Malalties obstructives
Exercici
Biomarker
COPD
Exercise
topic Marcadors bioquímics
Pulmons--Malalties obstructives
Exercici
Biomarker
COPD
Exercise
description INTRODUCTION: Abnormalities of autonomic function have been reported in patients with chronic obstructive pulmonary disease (COPD). Our objectives were to identify determinants of abnormal heart rate recovery at 1 min (HRR1) following completion of the 6-min walk test (6MWT) in COPD and to establish whether abnormal HRR1 predicts acute exacerbations (AECOPD). METHODS: Hundred one COPD patients (FEV1 (SD) 53 (19) % predicted) were prospectively recruited in a multi-center study. HRR1 after the 6MWT was evaluated as the difference between heart rate at the end of the test and 1 min into the recovery (HRR1). Linear and logistic regression was used to identify predictors of HRR1 and AECOPD, respectively. The best HRR1 cut-off point to predict AECOPD was selected using the receiver operating characteristics (ROC) curves. The follow-up period was 12 months. RESULTS: Distance covered during the 6MWT (m) and DLco (% predicted) were independently associated with HRR1 (r 2 = 0.51, p = 0.001). Among several potential covariates, HRR1 emerged as the most significant predictor of AECOPD (Odds ratio [OR], 0.91 per beat of recovery; 95% confidence interval [CI], 0.85-0.97; p = 0.02). The ROC analysis indicated that subjects with HRR1 less than 14 beats (AUC, 0.71 [CI] 0.60-0.80; p = 0.0001) were more likely to suffer an exacerbation during the follow-up period (for HRR1, p = 0.004 [log-rank test]). CONCLUSIONS: HRR1 after the 6MWT is an independent predictor factor for AECOPD. Further studies are warranted to examine the physiological mechanisms associating a delayed HRR and acute exacerbations in COPD patients.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34966
http://dx.doi.org/10.1007/s00408-017-0027-0
url http://hdl.handle.net/10230/34966
http://dx.doi.org/10.1007/s00408-017-0027-0
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Lung. 2017 Aug;195(4):463-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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