Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty

The re-use of genes in new organs forms the base of many evolutionary novelties. A well-characterised case is the recruitment of the posterior spiracle gene network to the Drosophila male genitalia. Here we find that this network has also been co-opted to the testis mesoderm where is required for sp...

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Autores: Molina-Gil, Sara, Sotillos, Sol, Espinosa-Vázquez, José Manuel, Almudí Cabrero, Isabel, Hombría, James C.-G.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/202044
Acceso en línea:https://hdl.handle.net/2445/202044
Access Level:acceso abierto
Palabra clave:Drosòfila
Gens
Transcripció genètica
Biologia molecular
Drosophila
Genes
Genetic transcription
Molecular biology
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spelling Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive noveltyMolina-Gil, SaraSotillos, SolEspinosa-Vázquez, José ManuelAlmudí Cabrero, IsabelHombría, James C.-G.DrosòfilaGensTranscripció genèticaBiologia molecularDrosophilaGenesGenetic transcriptionMolecular biologyThe re-use of genes in new organs forms the base of many evolutionary novelties. A well-characterised case is the recruitment of the posterior spiracle gene network to the Drosophila male genitalia. Here we find that this network has also been co-opted to the testis mesoderm where is required for sperm liberation, providing an example of sequentially repeated developmental co options. Associated to this co-option event, an evolutionary expression novelty appeared, the activation of the posterior segment determinant Engrailed to the anterior A8 segment controlled by common testis and spiracle regulatory elements. Enhancer deletion shows that A8 anterior Engrailed activation is not required for spiracle development but only necessary in the testis. Our study presents an example of pre-adaptive developmental novelty: the activation of the Engrailed transcription factor in the anterior compart ment of the A8 segment where, despite having no specific function, opens the possibility of this developmental factor acquiring one. We propose that recently co-opted networks become interlocked, so that any change to the network because of its function in one organ, will be mirrored by other organs even if it provides no selective advantage to them.Nature Publishing Group2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/202044Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41467-023-41414-3Nature Communications, 2023, vol. 14https://doi.org/10.1038/s41467-023-41414-3cc-by (c) Molina-Gil, Sara et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2020442026-05-29T05:05:01Z
dc.title.none.fl_str_mv Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
spellingShingle Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
Molina-Gil, Sara
Drosòfila
Gens
Transcripció genètica
Biologia molecular
Drosophila
Genes
Genetic transcription
Molecular biology
title_short Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_full Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_fullStr Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_full_unstemmed Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_sort Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
dc.creator.none.fl_str_mv Molina-Gil, Sara
Sotillos, Sol
Espinosa-Vázquez, José Manuel
Almudí Cabrero, Isabel
Hombría, James C.-G.
author Molina-Gil, Sara
author_facet Molina-Gil, Sara
Sotillos, Sol
Espinosa-Vázquez, José Manuel
Almudí Cabrero, Isabel
Hombría, James C.-G.
author_role author
author2 Sotillos, Sol
Espinosa-Vázquez, José Manuel
Almudí Cabrero, Isabel
Hombría, James C.-G.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Drosòfila
Gens
Transcripció genètica
Biologia molecular
Drosophila
Genes
Genetic transcription
Molecular biology
topic Drosòfila
Gens
Transcripció genètica
Biologia molecular
Drosophila
Genes
Genetic transcription
Molecular biology
description The re-use of genes in new organs forms the base of many evolutionary novelties. A well-characterised case is the recruitment of the posterior spiracle gene network to the Drosophila male genitalia. Here we find that this network has also been co-opted to the testis mesoderm where is required for sperm liberation, providing an example of sequentially repeated developmental co options. Associated to this co-option event, an evolutionary expression novelty appeared, the activation of the posterior segment determinant Engrailed to the anterior A8 segment controlled by common testis and spiracle regulatory elements. Enhancer deletion shows that A8 anterior Engrailed activation is not required for spiracle development but only necessary in the testis. Our study presents an example of pre-adaptive developmental novelty: the activation of the Engrailed transcription factor in the anterior compart ment of the A8 segment where, despite having no specific function, opens the possibility of this developmental factor acquiring one. We propose that recently co-opted networks become interlocked, so that any change to the network because of its function in one organ, will be mirrored by other organs even if it provides no selective advantage to them.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/202044
url https://hdl.handle.net/2445/202044
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41467-023-41414-3
Nature Communications, 2023, vol. 14
https://doi.org/10.1038/s41467-023-41414-3
dc.rights.none.fl_str_mv cc-by (c) Molina-Gil, Sara et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Molina-Gil, Sara et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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