The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide?
Dopamine-replacing therapies are an effective treatment for the motor aspects of Parkinson's disease. However, its precise effect over the cognitive resting-state networks is not clear; whether dopaminergic treatment normalizes their functional connectivity-as in other networks- and the lin...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/53481 |
| Acesso em linha: | http://hdl.handle.net/10230/53481 http://dx.doi.org/10.1002/hbm.25650 |
| Access Level: | acceso abierto |
| Palavra-chave: | Parkinson&apos s disease Cognitive networks Dopamine Functional MRI |
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The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide?Aracil-Bolaños, IgnacioSampedro, FredericPujol Martí, Jesús, 1981-Soriano Mas, CarlesGonzalez-de-Echávarri José MaríaKulisevsky, Jaime J.Pagonabarraga, JavierParkinson&aposs diseaseCognitive networksDopamineFunctional MRIDopamine-replacing therapies are an effective treatment for the motor aspects of Parkinson's disease. However, its precise effect over the cognitive resting-state networks is not clear; whether dopaminergic treatment normalizes their functional connectivity-as in other networks- and the links with cognitive decline are presently unknown. We recruited 35 nondemented PD patients and 16 age-matched controls. Clinical and neuropsychological assessments were performed at baseline, and conversion to dementia was assessed in a 10 year follow-up. Structural and functional brain imaging were acquired in both the ON and practical OFF conditions. We assessed functional connectivity in both medication states compared to healthy controls, connectivity differences within participants related to the ON/OFF condition, and baseline connectivity of PD participants that converted to dementia compared to those who did not convert. PD participants showed and increased frontoparietal connectivity compared to controls: a pattern of higher connectivity between salience (SN) and default-mode (DMN) networks both in the ON and OFF states. Within PD patients, this higher SN-DMN connectivity characterized the participants in the ON state, while within-DMN connectivity prevailed in the OFF state. Interestingly, participants who converted to dementia also showed higher SN-DMN connectivity in their baseline ON scans compared to nonconverters. To conclude, PD patients showed higher frontoparietal connectivity in cognitive networks compared to healthy controls, irrespective of medication status, but dopaminergic treatment specifically promoted SN-DM hyperconnectivity.Wiley202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53481http://dx.doi.org/10.1002/hbm.25650reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCopyright © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/534812026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? |
| title |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? |
| spellingShingle |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? Aracil-Bolaños, Ignacio Parkinson&apos s disease Cognitive networks Dopamine Functional MRI |
| title_short |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? |
| title_full |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? |
| title_fullStr |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? |
| title_full_unstemmed |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? |
| title_sort |
The impact of dopaminergic treatment over cognitive networks in Parkinson's disease: stemming the tide? |
| dc.creator.none.fl_str_mv |
Aracil-Bolaños, Ignacio Sampedro, Frederic Pujol Martí, Jesús, 1981- Soriano Mas, Carles Gonzalez-de-Echávarri José María Kulisevsky, Jaime J. Pagonabarraga, Javier |
| author |
Aracil-Bolaños, Ignacio |
| author_facet |
Aracil-Bolaños, Ignacio Sampedro, Frederic Pujol Martí, Jesús, 1981- Soriano Mas, Carles Gonzalez-de-Echávarri José María Kulisevsky, Jaime J. Pagonabarraga, Javier |
| author_role |
author |
| author2 |
Sampedro, Frederic Pujol Martí, Jesús, 1981- Soriano Mas, Carles Gonzalez-de-Echávarri José María Kulisevsky, Jaime J. Pagonabarraga, Javier |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Parkinson&apos s disease Cognitive networks Dopamine Functional MRI |
| topic |
Parkinson&apos s disease Cognitive networks Dopamine Functional MRI |
| description |
Dopamine-replacing therapies are an effective treatment for the motor aspects of Parkinson's disease. However, its precise effect over the cognitive resting-state networks is not clear; whether dopaminergic treatment normalizes their functional connectivity-as in other networks- and the links with cognitive decline are presently unknown. We recruited 35 nondemented PD patients and 16 age-matched controls. Clinical and neuropsychological assessments were performed at baseline, and conversion to dementia was assessed in a 10 year follow-up. Structural and functional brain imaging were acquired in both the ON and practical OFF conditions. We assessed functional connectivity in both medication states compared to healthy controls, connectivity differences within participants related to the ON/OFF condition, and baseline connectivity of PD participants that converted to dementia compared to those who did not convert. PD participants showed and increased frontoparietal connectivity compared to controls: a pattern of higher connectivity between salience (SN) and default-mode (DMN) networks both in the ON and OFF states. Within PD patients, this higher SN-DMN connectivity characterized the participants in the ON state, while within-DMN connectivity prevailed in the OFF state. Interestingly, participants who converted to dementia also showed higher SN-DMN connectivity in their baseline ON scans compared to nonconverters. To conclude, PD patients showed higher frontoparietal connectivity in cognitive networks compared to healthy controls, irrespective of medication status, but dopaminergic treatment specifically promoted SN-DM hyperconnectivity. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/53481 http://dx.doi.org/10.1002/hbm.25650 |
| url |
http://hdl.handle.net/10230/53481 http://dx.doi.org/10.1002/hbm.25650 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
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Wiley |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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