The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes

To describe in a real-world setting the achievement of physician-selected individualized HbA1c targets in individuals with type 2 diabetes, newly or recently initiated with basal insulin, and the association of hypoglycaemia with target achievement. A 12-week, prospective, single-arm, observational...

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Autores: Meneghini, Luigi F., Mauricio, Didac|||0000-0002-2868-0250, Orsi, Emanuela, Lalic, Nebojsa M., Cali, Anna M.G., Westerbacka, Jukka, Stella, Peter, Candelas, Christophe, Pilorget, Valerie, Perfetti, Riccardo, Khunti, Kamlesh|||0000-0003-2343-7099
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:286304
Acesso em linha:https://ddd.uab.cat/record/286304
https://dx.doi.org/urn:doi:10.1111/dom.13673
Access Level:acceso abierto
Palavra-chave:Basal insulin
Glycaemic control
Hypoglycaemia
Insulin therapy
Observational study
Type 2 diabetes
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spelling The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetesAchieving HbA1c targets with basal insulin in a real-world settingMeneghini, Luigi F.Mauricio, Didac|||0000-0002-2868-0250Orsi, EmanuelaLalic, Nebojsa M.Cali, Anna M.G.Westerbacka, JukkaStella, PeterCandelas, ChristophePilorget, ValeriePerfetti, RiccardoKhunti, Kamlesh|||0000-0003-2343-7099Basal insulinGlycaemic controlHypoglycaemiaInsulin therapyObservational studyType 2 diabetesTo describe in a real-world setting the achievement of physician-selected individualized HbA1c targets in individuals with type 2 diabetes, newly or recently initiated with basal insulin, and the association of hypoglycaemia with target achievement. A 12-week, prospective, single-arm, observational study of adults with type 2 diabetes, either newly initiated with any basal insulin or start on basal insulin within the preceding 12 months. At enrollment, eligible participants from 28 countries were treated with or without oral antihyperglycaemic drugs and/or GLP-1 receptor agonists. Results: Individualized targets for almost all of the 3139 evaluable participants (99.7%) had been set by their physicians, with 57% of participants having HbA1c targets between 7.0% and <7.5% (53 and <58 mmol/mol). By week 12, 28% and 27% of newly and previously initiated participants, respectively, achieved individualized HbA1c targets with modest average increases in daily insulin dose of 9 and 5 U (0.10 and 0.06 U/kg), respectively, from baseline (14 and 23 U [0.17 and 0.29 U/kg], respectively). Overall, 16% of participants experienced at least one episode of hypoglycaemia. Both the incidence and frequency of hypoglycaemia, but not the severity, were positively associated with a higher likelihood of achieving individualized HbA1c targets (P < 0.05). Conclusions: In this prospective real-world study, most participants using basal insulin did not achieve the individualized HbA1c targets set by their physicians. Participants who experienced symptomatic hypoglycaemia were more likely to achieve HbA1c targets than those who did not.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/286304https://dx.doi.org/urn:doi:10.1111/dom.13673reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2863042026-06-06T12:50:31Z
dc.title.none.fl_str_mv The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
Achieving HbA1c targets with basal insulin in a real-world setting
title The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
spellingShingle The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
Meneghini, Luigi F.
Basal insulin
Glycaemic control
Hypoglycaemia
Insulin therapy
Observational study
Type 2 diabetes
title_short The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
title_full The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
title_fullStr The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
title_full_unstemmed The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
title_sort The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes
dc.creator.none.fl_str_mv Meneghini, Luigi F.
Mauricio, Didac|||0000-0002-2868-0250
Orsi, Emanuela
Lalic, Nebojsa M.
Cali, Anna M.G.
Westerbacka, Jukka
Stella, Peter
Candelas, Christophe
Pilorget, Valerie
Perfetti, Riccardo
Khunti, Kamlesh|||0000-0003-2343-7099
author Meneghini, Luigi F.
author_facet Meneghini, Luigi F.
Mauricio, Didac|||0000-0002-2868-0250
Orsi, Emanuela
Lalic, Nebojsa M.
Cali, Anna M.G.
Westerbacka, Jukka
Stella, Peter
Candelas, Christophe
Pilorget, Valerie
Perfetti, Riccardo
Khunti, Kamlesh|||0000-0003-2343-7099
author_role author
author2 Mauricio, Didac|||0000-0002-2868-0250
Orsi, Emanuela
Lalic, Nebojsa M.
Cali, Anna M.G.
Westerbacka, Jukka
Stella, Peter
Candelas, Christophe
Pilorget, Valerie
Perfetti, Riccardo
Khunti, Kamlesh|||0000-0003-2343-7099
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Basal insulin
Glycaemic control
Hypoglycaemia
Insulin therapy
Observational study
Type 2 diabetes
topic Basal insulin
Glycaemic control
Hypoglycaemia
Insulin therapy
Observational study
Type 2 diabetes
description To describe in a real-world setting the achievement of physician-selected individualized HbA1c targets in individuals with type 2 diabetes, newly or recently initiated with basal insulin, and the association of hypoglycaemia with target achievement. A 12-week, prospective, single-arm, observational study of adults with type 2 diabetes, either newly initiated with any basal insulin or start on basal insulin within the preceding 12 months. At enrollment, eligible participants from 28 countries were treated with or without oral antihyperglycaemic drugs and/or GLP-1 receptor agonists. Results: Individualized targets for almost all of the 3139 evaluable participants (99.7%) had been set by their physicians, with 57% of participants having HbA1c targets between 7.0% and <7.5% (53 and <58 mmol/mol). By week 12, 28% and 27% of newly and previously initiated participants, respectively, achieved individualized HbA1c targets with modest average increases in daily insulin dose of 9 and 5 U (0.10 and 0.06 U/kg), respectively, from baseline (14 and 23 U [0.17 and 0.29 U/kg], respectively). Overall, 16% of participants experienced at least one episode of hypoglycaemia. Both the incidence and frequency of hypoglycaemia, but not the severity, were positively associated with a higher likelihood of achieving individualized HbA1c targets (P < 0.05). Conclusions: In this prospective real-world study, most participants using basal insulin did not achieve the individualized HbA1c targets set by their physicians. Participants who experienced symptomatic hypoglycaemia were more likely to achieve HbA1c targets than those who did not.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/286304
https://dx.doi.org/urn:doi:10.1111/dom.13673
url https://ddd.uab.cat/record/286304
https://dx.doi.org/urn:doi:10.1111/dom.13673
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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