High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents

This study aimed to assess the effect of exercise on high-sensitivity cardiac troponin T (hs-cTnT) concentrations in children and adolescents and to examine whether sex, maturational status, anthropometric characteristics, cardiorespiratory fitness, and physical activity influence the hs-cTnT respon...

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Autores: Conesa Milian, Enric, Batalla Gavaldà, Abraham, Hernández González, Vicenç, López Laval, Isaac, Corbi, Francisco, Cirer Sastre, Rafel, Legaz Arrese, Alejandro, Reverter Masia, Joaquin
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2026
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::c0e0cff7f5c9b4177210eb66dc42c889
Acesso em linha:https://hdl.handle.net/2445/229450
Access Level:Acceso aberto
Palavra-chave:Infants
Exercici
Children
Exercise
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spelling High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and AdolescentsConesa Milian, EnricBatalla Gavaldà, AbrahamHernández González, VicençLópez Laval, IsaacCorbi, FranciscoCirer Sastre, RafelLegaz Arrese, AlejandroReverter Masia, JoaquinInfantsExerciciChildrenExerciseThis study aimed to assess the effect of exercise on high-sensitivity cardiac troponin T (hs-cTnT) concentrations in children and adolescents and to examine whether sex, maturational status, anthropometric characteristics, cardiorespiratory fitness, and physical activity influence the hs-cTnT response. In this trial 733 participants completed the 20-m shuttle run test. Venous blood samples were collected at rest and 3 h postexercise to determine hs-cTnT concentrations. We included 296 girls and 437 boys (12.2 ± 1.7 years; 40% girls). At baseline, 61% of participants had hs-cTnT values below the limit of detection (LoD), and 2.5% exceeded the upper reference limit (URL). Postexercise, 36% remained below LoD, while 7.5% exceeded the URL. Overall, hs-cTnT increased from baseline to 3 h postexercise in 56.2% of participants. Linear mixed-effects models showed a significant main effect of time (β = -0.42, 95% CI 0.35-0.49; p < 0.01) and no main effect of sex (p = 0.85), although a small but significant time × sex interaction was observed (β = -0.11, 95% CI -0.20 to -0.02; p = 0.021), indicating a slightly greater exercise-induced increase in girls. Additional significant time × covariate interactions were identified for maturational, anthropometric, and fitness-related variables. However, these factors together explained only a small proportion of the overall variability in hs-cTnT response. Consequently, the 20-m shuttle run test induces a significant increase in hs-cTnT concentrations in children and adolescents. Exercise-induced hs-cTnT release is common but highly heterogeneous, and is only partly explained by sex, maturational, anthropometric, and fitness-related factors, suggesting an important contribution of individual-specific determinants not captured by conventional variables.John Wiley & Sons2026202620262026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/229450https://hdl.handle.net/2445/229450reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1111/sms.70253Scandinavian Journal of Medicine & Science in Sports, 2026, vol. 36, num.3https://doi.org/10.1111/sms.70253cc-by-nc-nd (c) Conesa Milian, Enric et al., 2026https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::c0e0cff7f5c9b4177210eb66dc42c8892026-05-29T05:05:01Z
dc.title.none.fl_str_mv High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
title High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
spellingShingle High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
Conesa Milian, Enric
Infants
Exercici
Children
Exercise
title_short High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
title_full High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
title_fullStr High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
title_full_unstemmed High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
title_sort High-Sensitivity Cardiac Troponin T Release After the 20-m Shuttle Run Test in 733 Healthy Children and Adolescents
dc.creator.none.fl_str_mv Conesa Milian, Enric
Batalla Gavaldà, Abraham
Hernández González, Vicenç
López Laval, Isaac
Corbi, Francisco
Cirer Sastre, Rafel
Legaz Arrese, Alejandro
Reverter Masia, Joaquin
author Conesa Milian, Enric
author_facet Conesa Milian, Enric
Batalla Gavaldà, Abraham
Hernández González, Vicenç
López Laval, Isaac
Corbi, Francisco
Cirer Sastre, Rafel
Legaz Arrese, Alejandro
Reverter Masia, Joaquin
author_role author
author2 Batalla Gavaldà, Abraham
Hernández González, Vicenç
López Laval, Isaac
Corbi, Francisco
Cirer Sastre, Rafel
Legaz Arrese, Alejandro
Reverter Masia, Joaquin
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infants
Exercici
Children
Exercise
topic Infants
Exercici
Children
Exercise
description This study aimed to assess the effect of exercise on high-sensitivity cardiac troponin T (hs-cTnT) concentrations in children and adolescents and to examine whether sex, maturational status, anthropometric characteristics, cardiorespiratory fitness, and physical activity influence the hs-cTnT response. In this trial 733 participants completed the 20-m shuttle run test. Venous blood samples were collected at rest and 3 h postexercise to determine hs-cTnT concentrations. We included 296 girls and 437 boys (12.2 ± 1.7 years; 40% girls). At baseline, 61% of participants had hs-cTnT values below the limit of detection (LoD), and 2.5% exceeded the upper reference limit (URL). Postexercise, 36% remained below LoD, while 7.5% exceeded the URL. Overall, hs-cTnT increased from baseline to 3 h postexercise in 56.2% of participants. Linear mixed-effects models showed a significant main effect of time (β = -0.42, 95% CI 0.35-0.49; p < 0.01) and no main effect of sex (p = 0.85), although a small but significant time × sex interaction was observed (β = -0.11, 95% CI -0.20 to -0.02; p = 0.021), indicating a slightly greater exercise-induced increase in girls. Additional significant time × covariate interactions were identified for maturational, anthropometric, and fitness-related variables. However, these factors together explained only a small proportion of the overall variability in hs-cTnT response. Consequently, the 20-m shuttle run test induces a significant increase in hs-cTnT concentrations in children and adolescents. Exercise-induced hs-cTnT release is common but highly heterogeneous, and is only partly explained by sex, maturational, anthropometric, and fitness-related factors, suggesting an important contribution of individual-specific determinants not captured by conventional variables.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/229450
https://hdl.handle.net/2445/229450
url https://hdl.handle.net/2445/229450
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1111/sms.70253
Scandinavian Journal of Medicine & Science in Sports, 2026, vol. 36, num.3
https://doi.org/10.1111/sms.70253
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Conesa Milian, Enric et al., 2026
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Conesa Milian, Enric et al., 2026
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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