Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice

This article belongs to the Special Issue Gut Microbiota and Immunity.

Detalles Bibliográficos
Autores: González-Portilla, Macarena, Montagud-Romero, Sandra, Navarrete, Francisco, Gasparyan, Ani, Manzanares, Jorge, Miñarro, José, Rodríguez-Arias, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/267624
Acceso en línea:http://hdl.handle.net/10261/267624
Access Level:acceso abierto
Palabra clave:Binge drinking
Inflammation
Alcohol
Cytokines
High-fat diet
Microbiota
Binge
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spelling Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in miceGonzález-Portilla, MacarenaMontagud-Romero, SandraNavarrete, FranciscoGasparyan, AniManzanares, JorgeMiñarro, JoséRodríguez-Arias, MartaBinge drinkingInflammationAlcoholCytokinesHigh-fat dietMicrobiotaBingeThis article belongs to the Special Issue Gut Microbiota and Immunity.Alcohol binge drinking (BD) and poor nutritional habits are two frequent behaviors among many adolescents that alter gut microbiota in a pro-inflammatory direction. Dysbiotic changes in the gut microbiome are observed after alcohol and high-fat diet (HFD) consumption, even before obesity onset. In this study, we investigate the neuroinflammatory response of adolescent BD when combined with a continuous or intermittent HFD and its effects on adult ethanol consumption by using a self-administration (SA) paradigm in mice. The inflammatory biomarkers IL-6 and CX3CL1 were measured in the striatum 24 h after BD, 3 weeks later and after the ethanol (EtOH) SA. Adolescent BD increased alcohol consumption in the oral SA and caused a greater motivation to seek the substance. Likewise, mice with intermittent access to HFD exhibited higher EtOH consumption, while the opposite effect was found in mice with continuous HFD access. Biochemical analyses showed that after BD and three weeks later, striatal levels of IL-6 and CX3CL1 were increased. In addition, in saline-treated mice, CX3CL1 was increased after continuous access to HFD. After oral SA procedure, striatal IL-6 was increased only in animals exposed to BD and HFD. In addition, striatal CX3CL1 levels were increased in all BD- and HFD-exposed groups. Overall, our findings show that adolescent BD and intermittent HFD increase adult alcohol intake and point to neuroinflammation as an important mechanism modulating this interaction.This research was funded by Spanish Ministry of Health, Social Affairs and Equality, Government Delegation for the National Drugs Plan (2018/013 to MRA and PNSD 2016I016 to JMa); Generalitat Valenciana, Conselleria de Educación, Dirección General de Universidades, Grupos de Investigación de excelencia, PROMETEOII/2018/132 to JMi; Ministerio de Economía y Competitividad’ (FIS, PI14/00438) to JMa. Instituto de Salud Carlos III, Red de Trastornos Adictivos (RD16/0017/0007 to JMi) and Unión Europea, Fondos FEDER “una manera de hacer Europa”.Peer reviewedMultidisciplinary Digital Publishing InstitutePlan Nacional sobre Drogas (España)Ministerio de Sanidad, Servicios Sociales e Igualdad (España)Generalitat ValencianaInstituto de Salud Carlos IIIEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/267624reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/ijms22105279Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2676242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
title Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
spellingShingle Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
González-Portilla, Macarena
Binge drinking
Inflammation
Alcohol
Cytokines
High-fat diet
Microbiota
Binge
title_short Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
title_full Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
title_fullStr Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
title_full_unstemmed Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
title_sort Pairing binge drinking and a high-fat diet in adolescence modulates the inflammatory effects of subsequent alcohol consumption in mice
dc.creator.none.fl_str_mv González-Portilla, Macarena
Montagud-Romero, Sandra
Navarrete, Francisco
Gasparyan, Ani
Manzanares, Jorge
Miñarro, José
Rodríguez-Arias, Marta
author González-Portilla, Macarena
author_facet González-Portilla, Macarena
Montagud-Romero, Sandra
Navarrete, Francisco
Gasparyan, Ani
Manzanares, Jorge
Miñarro, José
Rodríguez-Arias, Marta
author_role author
author2 Montagud-Romero, Sandra
Navarrete, Francisco
Gasparyan, Ani
Manzanares, Jorge
Miñarro, José
Rodríguez-Arias, Marta
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Plan Nacional sobre Drogas (España)
Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
Generalitat Valenciana
Instituto de Salud Carlos III
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Binge drinking
Inflammation
Alcohol
Cytokines
High-fat diet
Microbiota
Binge
topic Binge drinking
Inflammation
Alcohol
Cytokines
High-fat diet
Microbiota
Binge
description This article belongs to the Special Issue Gut Microbiota and Immunity.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/267624
url http://hdl.handle.net/10261/267624
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/ijms22105279
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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