Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media

Over the past decades, the development of nanoparticles (NPs) to increase the efficiency of clinical treatments has been subject of intense research. Yet, most NPs have been reported to possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) pres...

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Authors: Ruiz González, Noelia, Esporrín Ubieto, David, Lopes Hortelão, Ana Candida, Fraire, Juan, Bakenecker, Anna, Guri Canals, Marta, Cugat, Ramon, Carrillo, Jose María, Garcia Batlletbo, Montserrat, Laiz, Patricia, Patiño Padial, Tania, Sánchez Ordóñez, Samuel
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214494
Online Access:https://hdl.handle.net/2445/214494
Access Level:Open access
Keyword:Nanopartícules
Enzims
Malalties de les articulacions
Nanoparticles
Enzymes
Joints diseases
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spelling Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous MediaRuiz González, NoeliaEsporrín Ubieto, DavidLopes Hortelão, Ana CandidaFraire, JuanBakenecker, AnnaGuri Canals, MartaCugat, RamonCarrillo, Jose MaríaGarcia Batlletbo, MontserratLaiz, PatriciaPatiño Padial, TaniaSánchez Ordóñez, SamuelNanopartículesEnzimsMalalties de les articulacionsNanoparticlesEnzymesJoints diseasesOver the past decades, the development of nanoparticles (NPs) to increase the efficiency of clinical treatments has been subject of intense research. Yet, most NPs have been reported to possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) present in the joints is mainly composed of hyaluronic acid (HA). These viscous media pose a challenge for many applications in nanomedicine, as passive NPs tend to become trapped in complex networks, which reduces their ability to reach the target location. This problem can be addressed by using active NPs (nanomotors, NMs) that are self-propelled by enzymatic reactions, although the development of enzyme-powered NMs, capable of navigating these viscous environments, remains a considerable challenge. Here, the synergistic effects of two NMs troops, namely hyaluronidase NMs (HyaNMs, Troop 1) and urease NMs (UrNMs, Troop 2) are demonstrated. Troop 1 interacts with the SF by reducing its viscosity, thus allowing Troop 2 to swim more easily through the SF. Through their collective motion, Troop 2 increases the diffusion of macromolecules. These results pave the way for more widespread use of enzyme-powered NMs, e.g., for treating joint injuries and improving therapeutic effectiveness compared with traditional methods. The conceptual idea of the novel approach using hyaluronidase NMs (HyaNMs) to interact with and reduce the viscosity of the synovial fluid (SF) and urease NMs (UrNMs) for a more efficient transport of therapeutic agents in joints.image2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion17 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/214494Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/smll.202309387Small, 2024, vol. 20, num. 11https://doi.org/10.1002/smll.202309387cc by-nc (c) Ruiz González, Noelia et al, 2024http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2144942026-05-29T05:05:01Z
dc.title.none.fl_str_mv Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
title Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
spellingShingle Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
Ruiz González, Noelia
Nanopartícules
Enzims
Malalties de les articulacions
Nanoparticles
Enzymes
Joints diseases
title_short Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
title_full Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
title_fullStr Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
title_full_unstemmed Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
title_sort Swarms of Enzyme-Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
dc.creator.none.fl_str_mv Ruiz González, Noelia
Esporrín Ubieto, David
Lopes Hortelão, Ana Candida
Fraire, Juan
Bakenecker, Anna
Guri Canals, Marta
Cugat, Ramon
Carrillo, Jose María
Garcia Batlletbo, Montserrat
Laiz, Patricia
Patiño Padial, Tania
Sánchez Ordóñez, Samuel
author Ruiz González, Noelia
author_facet Ruiz González, Noelia
Esporrín Ubieto, David
Lopes Hortelão, Ana Candida
Fraire, Juan
Bakenecker, Anna
Guri Canals, Marta
Cugat, Ramon
Carrillo, Jose María
Garcia Batlletbo, Montserrat
Laiz, Patricia
Patiño Padial, Tania
Sánchez Ordóñez, Samuel
author_role author
author2 Esporrín Ubieto, David
Lopes Hortelão, Ana Candida
Fraire, Juan
Bakenecker, Anna
Guri Canals, Marta
Cugat, Ramon
Carrillo, Jose María
Garcia Batlletbo, Montserrat
Laiz, Patricia
Patiño Padial, Tania
Sánchez Ordóñez, Samuel
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Nanopartícules
Enzims
Malalties de les articulacions
Nanoparticles
Enzymes
Joints diseases
topic Nanopartícules
Enzims
Malalties de les articulacions
Nanoparticles
Enzymes
Joints diseases
description Over the past decades, the development of nanoparticles (NPs) to increase the efficiency of clinical treatments has been subject of intense research. Yet, most NPs have been reported to possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) present in the joints is mainly composed of hyaluronic acid (HA). These viscous media pose a challenge for many applications in nanomedicine, as passive NPs tend to become trapped in complex networks, which reduces their ability to reach the target location. This problem can be addressed by using active NPs (nanomotors, NMs) that are self-propelled by enzymatic reactions, although the development of enzyme-powered NMs, capable of navigating these viscous environments, remains a considerable challenge. Here, the synergistic effects of two NMs troops, namely hyaluronidase NMs (HyaNMs, Troop 1) and urease NMs (UrNMs, Troop 2) are demonstrated. Troop 1 interacts with the SF by reducing its viscosity, thus allowing Troop 2 to swim more easily through the SF. Through their collective motion, Troop 2 increases the diffusion of macromolecules. These results pave the way for more widespread use of enzyme-powered NMs, e.g., for treating joint injuries and improving therapeutic effectiveness compared with traditional methods. The conceptual idea of the novel approach using hyaluronidase NMs (HyaNMs) to interact with and reduce the viscosity of the synovial fluid (SF) and urease NMs (UrNMs) for a more efficient transport of therapeutic agents in joints.image
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214494
url https://hdl.handle.net/2445/214494
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/smll.202309387
Small, 2024, vol. 20, num. 11
https://doi.org/10.1002/smll.202309387
dc.rights.none.fl_str_mv cc by-nc (c) Ruiz González, Noelia et al, 2024
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Ruiz González, Noelia et al, 2024
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17 p.
application/pdf
application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421996683558913
score 15.81155

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