Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation

Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000...

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Autores: Renaldo Fernández, André, Sánchez Tarjuelo, Rodrigo, Cravedi, Paolo, Ochando, Jordi, López Hoyos, Marcos|||0000-0003-0562-427X
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/21818
Acceso en línea:http://hdl.handle.net/10902/21818
Access Level:acceso abierto
Palabra clave:Ischemia reperfusion injury
Cell metabolism
Innate immunity
Hypoxia
Cell death
RNA interference
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spelling Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ TransplantationRenaldo Fernández, AndréSánchez Tarjuelo, RodrigoCravedi, PaoloOchando, JordiLópez Hoyos, Marcos|||0000-0003-0562-427XIschemia reperfusion injuryCell metabolismInnate immunityHypoxiaCell deathRNA interferenceThanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI.MDPIUniversidad de Cantabria20202020-11-13journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/21818Int. J. Mol. Sci. 2020, 21(22), 8549reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/218182026-06-02T12:39:31Z
dc.title.none.fl_str_mv Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
title Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
spellingShingle Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
Renaldo Fernández, André
Ischemia reperfusion injury
Cell metabolism
Innate immunity
Hypoxia
Cell death
RNA interference
title_short Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
title_full Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
title_fullStr Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
title_full_unstemmed Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
title_sort Review: Ischemia Reperfusion Injury?A Translational Perspective in Organ Transplantation
dc.creator.none.fl_str_mv Renaldo Fernández, André
Sánchez Tarjuelo, Rodrigo
Cravedi, Paolo
Ochando, Jordi
López Hoyos, Marcos|||0000-0003-0562-427X
author Renaldo Fernández, André
author_facet Renaldo Fernández, André
Sánchez Tarjuelo, Rodrigo
Cravedi, Paolo
Ochando, Jordi
López Hoyos, Marcos|||0000-0003-0562-427X
author_role author
author2 Sánchez Tarjuelo, Rodrigo
Cravedi, Paolo
Ochando, Jordi
López Hoyos, Marcos|||0000-0003-0562-427X
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Ischemia reperfusion injury
Cell metabolism
Innate immunity
Hypoxia
Cell death
RNA interference
topic Ischemia reperfusion injury
Cell metabolism
Innate immunity
Hypoxia
Cell death
RNA interference
description Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-11-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/21818
url http://hdl.handle.net/10902/21818
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Int. J. Mol. Sci. 2020, 21(22), 8549
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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