Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models

Introduction. The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated wi...

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Autores: Sanz Blasco, Rubén, Ruiz Sánchez de León, José María, Ávila Villanueva, Marina, Valentí‐Soler, Meritxel, Gómez‐Ramírez, Jaime, Fernández Blázquez, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/102995
Acceso en línea:https://hdl.handle.net/20.500.14352/102995
Access Level:acceso abierto
Palabra clave:Alzheimer´s disease
Dementia
Mild cognitive impairment
Multi-state markov model
Normal cognition
Subjective cognitive decline
Psicología (Psicología)
61 Psicología
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spelling Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov modelsSanz Blasco, RubénRuiz Sánchez de León, José MaríaÁvila Villanueva, MarinaValentí‐Soler, MeritxelGómez‐Ramírez, JaimeFernández Blázquez, Miguel ÁngelAlzheimer´s diseaseDementiaMild cognitive impairmentMulti-state markov modelNormal cognitionSubjective cognitive declinePsicología (Psicología)61 PsicologíaIntroduction. The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon. Methods. A total of 985 Spanish community‐dwelling individuals aged 70 years and over at baseline were monitored for 5 years. During this time, 173 MCI and 36 dementia cases were identified. Multi‐state Markov models were performed to characterize transitions between states through the dementia continuum. Results. The rate of reversion from MCI to NC was 11%. There were significant non‐modifiable (age, socioeconomic status, or apolipoprotein E) and modifiable factors (cognitive training or absence of affective symptoms) associated with reversion. Discussion. Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC.Alzheimer's Association / WileyUniversidad Complutense de Madrid20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/102995reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1029952026-06-02T12:44:21Z
dc.title.none.fl_str_mv Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
title Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
spellingShingle Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
Sanz Blasco, Rubén
Alzheimer´s disease
Dementia
Mild cognitive impairment
Multi-state markov model
Normal cognition
Subjective cognitive decline
Psicología (Psicología)
61 Psicología
title_short Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
title_full Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
title_fullStr Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
title_full_unstemmed Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
title_sort Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
dc.creator.none.fl_str_mv Sanz Blasco, Rubén
Ruiz Sánchez de León, José María
Ávila Villanueva, Marina
Valentí‐Soler, Meritxel
Gómez‐Ramírez, Jaime
Fernández Blázquez, Miguel Ángel
author Sanz Blasco, Rubén
author_facet Sanz Blasco, Rubén
Ruiz Sánchez de León, José María
Ávila Villanueva, Marina
Valentí‐Soler, Meritxel
Gómez‐Ramírez, Jaime
Fernández Blázquez, Miguel Ángel
author_role author
author2 Ruiz Sánchez de León, José María
Ávila Villanueva, Marina
Valentí‐Soler, Meritxel
Gómez‐Ramírez, Jaime
Fernández Blázquez, Miguel Ángel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Alzheimer´s disease
Dementia
Mild cognitive impairment
Multi-state markov model
Normal cognition
Subjective cognitive decline
Psicología (Psicología)
61 Psicología
topic Alzheimer´s disease
Dementia
Mild cognitive impairment
Multi-state markov model
Normal cognition
Subjective cognitive decline
Psicología (Psicología)
61 Psicología
description Introduction. The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon. Methods. A total of 985 Spanish community‐dwelling individuals aged 70 years and over at baseline were monitored for 5 years. During this time, 173 MCI and 36 dementia cases were identified. Multi‐state Markov models were performed to characterize transitions between states through the dementia continuum. Results. The rate of reversion from MCI to NC was 11%. There were significant non‐modifiable (age, socioeconomic status, or apolipoprotein E) and modifiable factors (cognitive training or absence of affective symptoms) associated with reversion. Discussion. Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/102995
url https://hdl.handle.net/20.500.14352/102995
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Alzheimer's Association / Wiley
publisher.none.fl_str_mv Alzheimer's Association / Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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