Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors

Accurate cancer diagnosis is crucial for selecting optimal treatments, yet current classification systems often include non-responders who receive ineffective therapies. Cancer-associated fibroblasts (CAFs) play a central role in tumor progression, and CAF biomarkers are increasingly recognized for...

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Detalhes bibliográficos
Autores: Peña, Raúl, Baulida, Josep
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/395593
Acesso em linha:http://hdl.handle.net/10261/395593
https://api.elsevier.com/content/abstract/scopus_id/105003247182
Access Level:Acceso aberto
Palavra-chave:Breast cancer
CAF heterogeneity
Cancer-associated fibroblast
Prognosis signature
Snail1
Tumor-stroma
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spelling Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumorsPeña, RaúlBaulida, JosepBreast cancerCAF heterogeneityCancer-associated fibroblastPrognosis signatureSnail1Tumor-stromaAccurate cancer diagnosis is crucial for selecting optimal treatments, yet current classification systems often include non-responders who receive ineffective therapies. Cancer-associated fibroblasts (CAFs) play a central role in tumor progression, and CAF biomarkers are increasingly recognized for their prognostic value. Recent studies have revealed significant heterogeneity within CAF populations, with distinct subtypes linked to different tumors and stages of disease. In this review, we summarize recent findings from patient samples and mouse models of breast cancer, focusing on gene signatures identified by single-cell RNA sequencing that define CAF subtypes and predict cancer prognosis. Additionally, we explore the genes and pathways regulated by Snail1, a transcription factor whose expression in breast and colon CAFs is associated with malignancy. Altogether these data emphasize the fibrotic and immunosuppressive roles of Snail1-expressing fibroblasts and unveil an undescribed streamlined Snail1-related gene signature in CAFs with prognostic potential in breast cancer and other solid tumors.Project PID2022-136968OB-I00 financed by MICIU/AEI /10.13039/501100011033 and FEDER, UE to Drs. Josep Baulida and Antonio García de Herreros.Peer reviewedElsevier BVAgencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/395593https://api.elsevier.com/content/abstract/scopus_id/105003247182reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136968OB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.bbcan.2025.189316https://doi.org/10.1016/j.bbcan.2025.189316Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3955932026-05-22T06:33:51Z
dc.title.none.fl_str_mv Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
title Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
spellingShingle Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
Peña, Raúl
Breast cancer
CAF heterogeneity
Cancer-associated fibroblast
Prognosis signature
Snail1
Tumor-stroma
title_short Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
title_full Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
title_fullStr Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
title_full_unstemmed Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
title_sort Snail1 as a key prognostic biomarker of cancer-associated fibroblasts in breast tumors
dc.creator.none.fl_str_mv Peña, Raúl
Baulida, Josep
author Peña, Raúl
author_facet Peña, Raúl
Baulida, Josep
author_role author
author2 Baulida, Josep
author2_role author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Breast cancer
CAF heterogeneity
Cancer-associated fibroblast
Prognosis signature
Snail1
Tumor-stroma
topic Breast cancer
CAF heterogeneity
Cancer-associated fibroblast
Prognosis signature
Snail1
Tumor-stroma
description Accurate cancer diagnosis is crucial for selecting optimal treatments, yet current classification systems often include non-responders who receive ineffective therapies. Cancer-associated fibroblasts (CAFs) play a central role in tumor progression, and CAF biomarkers are increasingly recognized for their prognostic value. Recent studies have revealed significant heterogeneity within CAF populations, with distinct subtypes linked to different tumors and stages of disease. In this review, we summarize recent findings from patient samples and mouse models of breast cancer, focusing on gene signatures identified by single-cell RNA sequencing that define CAF subtypes and predict cancer prognosis. Additionally, we explore the genes and pathways regulated by Snail1, a transcription factor whose expression in breast and colon CAFs is associated with malignancy. Altogether these data emphasize the fibrotic and immunosuppressive roles of Snail1-expressing fibroblasts and unveil an undescribed streamlined Snail1-related gene signature in CAFs with prognostic potential in breast cancer and other solid tumors.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/395593
https://api.elsevier.com/content/abstract/scopus_id/105003247182
url http://hdl.handle.net/10261/395593
https://api.elsevier.com/content/abstract/scopus_id/105003247182
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136968OB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1016/j.bbcan.2025.189316
https://doi.org/10.1016/j.bbcan.2025.189316
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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