Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells

14 p.

Detalles Bibliográficos
Autores: Calvino Fernández, Mirian, Benito Martínez, Selma|||0000-0002-3118-0564, Parra Cid, Trinidad
Tipo de recurso: artículo
Fecha de publicación:2008
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/59284
Acceso en línea:http://hdl.handle.net/10017/59284
https://dx.doi.org/10.1007/s10495-008-0255-0
Access Level:acceso abierto
Palabra clave:Apoptosis
Gastric epithelial cells
Helicobacter pylori
Mitochondria and Reactive oxygen species
Medicina
Medicine
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spelling Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cellsCalvino Fernández, MirianBenito Martínez, Selma|||0000-0002-3118-0564Parra Cid, TrinidadApoptosisGastric epithelial cellsHelicobacter pyloriMitochondria and Reactive oxygen speciesMedicinaMedicine14 p.Helicobacter pylori is a gram negative bacterium that infects the human stomach of approximately half of the world?s population. It produces oxidative stress, and mitochondria are one of the possible targets and the major intracellular source of free radicals. The present study was aimed at determining mitochondrial alterations in H. pylori-infected gastric epithelial cells and its relationship with oxidative stress, one of the recognized causes of apoptotic processes. Cells were treated with a strain of H. pylori for 24 h. Cellular oxidative burst, antioxidant defense analysis, mitochondrial alterations and apoptosisrelated processes were measured. Our data provide evidence on how superoxide acts on mitochondria to initiate apoptotic pathways, with these changes occurring in the presence of mitocondrial depolarization and other morphological and functional changes. Treatment of infected cells with Vitamin E prevented increases in intracelular ROS and mitochondrial damage consistent with H. pylori inducing a mitochondrial ROS mediated programmed cell death pathway.Junta de Comunidades de Castilla- La Mancha20082008-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/59284https://dx.doi.org/10.1007/s10495-008-0255-0reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengJunta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/592842026-06-18T11:13:07Z
dc.title.none.fl_str_mv Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
title Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
spellingShingle Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
Calvino Fernández, Mirian
Apoptosis
Gastric epithelial cells
Helicobacter pylori
Mitochondria and Reactive oxygen species
Medicina
Medicine
title_short Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
title_full Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
title_fullStr Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
title_full_unstemmed Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
title_sort Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells
dc.creator.none.fl_str_mv Calvino Fernández, Mirian
Benito Martínez, Selma|||0000-0002-3118-0564
Parra Cid, Trinidad
author Calvino Fernández, Mirian
author_facet Calvino Fernández, Mirian
Benito Martínez, Selma|||0000-0002-3118-0564
Parra Cid, Trinidad
author_role author
author2 Benito Martínez, Selma|||0000-0002-3118-0564
Parra Cid, Trinidad
author2_role author
author
dc.subject.none.fl_str_mv Apoptosis
Gastric epithelial cells
Helicobacter pylori
Mitochondria and Reactive oxygen species
Medicina
Medicine
topic Apoptosis
Gastric epithelial cells
Helicobacter pylori
Mitochondria and Reactive oxygen species
Medicina
Medicine
description 14 p.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/59284
https://dx.doi.org/10.1007/s10495-008-0255-0
url http://hdl.handle.net/10017/59284
https://dx.doi.org/10.1007/s10495-008-0255-0
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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