Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice

[Background]: The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect both central and peripheral nervous system in a murine model of ALS.

Detalhes bibliográficos
Autores: Martínez-Muriana, Anna, Pastor, Diego, Mancuso, Renzo, Rando, Amaya, Osta, Rosario, Martínez, Salvador, López-Vales, Rubèn, Navarro, Xavier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/217731
Acesso em linha:http://hdl.handle.net/10261/217731
Access Level:acceso abierto
Descrição
Resumo:[Background]: The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect both central and peripheral nervous system in a murine model of ALS.