Pathologist-initiated reflex testing for biomarkers in non-small-cell lung cancer: expert consensus on the rationale and considerations for implementation

Biomarker tests in lung cancer have been traditionally ordered by the treating oncologist upon confirmation of an appropriate pathological diagnosis. The delay this introduces prolongs yet further what is already a complex, multi-stage, pre-treatment pathway and delays the start of first-line system...

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Detalles Bibliográficos
Autores: Gosney, J.R. (J. R.)|||/items/78cf9cb8-9341-493b-b6e9-867053fc1d8c, Paz-Ares, L. (Luis)|||/items/ba2de41a-32d0-478a-a5fb-616a69fb1289, Jänne, P. (P.)|||/items/3db30e1a-2a9a-4e4c-bc23-3f77d2c257d7, Kerr, K.M. (K. M.)|||/items/2335d07a-f4b4-4341-b2a1-8ae5a5c5426d, Leighl, N.B. (Natasha B.)|||/items/fd44e147-5f9e-408e-ad88-803f89d53ec0, Lozano-Escario, M.D. (María Dolores)|||/items/af4b6129-2049-4083-8d70-40d37f172598, Malapelle, U. (Umberto)|||/items/69c3bb00-e111-4b73-bcbd-38d51dc52f7b, Mok, T.S. (Tony S.)|||/items/e91edeb3-d511-44a4-a72c-338e96ade778, Sheffield, B.S. (B. S.)|||/items/8a591f03-29ce-4e20-a96c-2ec51c72b565, Tufmah, A. (A.)|||/items/7e33ba6e-bf17-4b06-a45c-d721b21246d9, Wistuba, I.I. (Ignacio I.)|||/items/59d4536f-fe3c-444f-9634-b679f9380185, Peters, S. (S.)|||/items/c902d1f8-270c-4663-bdaa-09aaee1e40c1
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/67601
Acceso en línea:https://hdl.handle.net/10171/67601
Access Level:acceso abierto
Palabra clave:Reflex testing
Molecular pathology
Turnaround time
Predictive biomarkers
NSCLC
Non-small-cell lung cancer
Descripción
Sumario:Biomarker tests in lung cancer have been traditionally ordered by the treating oncologist upon confirmation of an appropriate pathological diagnosis. The delay this introduces prolongs yet further what is already a complex, multi-stage, pre-treatment pathway and delays the start of first-line systemic treatment, which is crucially informed by the results of such analysis. Reflex testing, in which the responsibility for testing for an agreed range of biomarkers lies with the pathologist, has been shown to standardise and expedite the process. Twelve experts discussed the rationale and considerations for implementing reflex testing as standard clinical practice.