Microdosimetry Maps in Continuous and Pulsed Alpha Beams
The experimental assessment of the linear energy transfer (LET) at micrometric scale with high resolution is mandatory to achieve biologically optimized treatment plans in hadron therapy. Therefore, it is crucial to create active radiation sensors able to quantify microdosimetry distributions in thr...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/420659 |
| Acceso en línea: | http://hdl.handle.net/10261/420659 https://api.elsevier.com/content/abstract/scopus_id/105019620714 |
| Access Level: | acceso abierto |
| Palabra clave: | alpha therapy hadron therapy microdosimetry particle detectors silicon microdosimeters http://metadata.un.org/sdg/9 Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation |
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Microdosimetry Maps in Continuous and Pulsed Alpha Beams |
| title |
Microdosimetry Maps in Continuous and Pulsed Alpha Beams |
| spellingShingle |
Microdosimetry Maps in Continuous and Pulsed Alpha Beams Zhu, Yuwei alpha therapy hadron therapy microdosimetry particle detectors silicon microdosimeters http://metadata.un.org/sdg/9 Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation |
| title_short |
Microdosimetry Maps in Continuous and Pulsed Alpha Beams |
| title_full |
Microdosimetry Maps in Continuous and Pulsed Alpha Beams |
| title_fullStr |
Microdosimetry Maps in Continuous and Pulsed Alpha Beams |
| title_full_unstemmed |
Microdosimetry Maps in Continuous and Pulsed Alpha Beams |
| title_sort |
Microdosimetry Maps in Continuous and Pulsed Alpha Beams |
| dc.creator.none.fl_str_mv |
Zhu, Yuwei Riera-Llobet, Carla Fleta, Celeste Manna, Maria Leite, Amelia Maia Lopez, Gaston Garcia Tavora, Vicente Garcia Bachiller-Perea, Diana Mouchard, Quentin Guardiola Salmerón, Consuelo |
| author |
Zhu, Yuwei |
| author_facet |
Zhu, Yuwei Riera-Llobet, Carla Fleta, Celeste Manna, Maria Leite, Amelia Maia Lopez, Gaston Garcia Tavora, Vicente Garcia Bachiller-Perea, Diana Mouchard, Quentin Guardiola Salmerón, Consuelo |
| author_role |
author |
| author2 |
Riera-Llobet, Carla Fleta, Celeste Manna, Maria Leite, Amelia Maia Lopez, Gaston Garcia Tavora, Vicente Garcia Bachiller-Perea, Diana Mouchard, Quentin Guardiola Salmerón, Consuelo |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Ciencia e Innovación (España) Agencia Estatal de Investigación (España) European Commission 0000-0002-0100-9360 0000-0002-9037-1539 0000-0002-0174-7451 Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
alpha therapy hadron therapy microdosimetry particle detectors silicon microdosimeters http://metadata.un.org/sdg/9 Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation |
| topic |
alpha therapy hadron therapy microdosimetry particle detectors silicon microdosimeters http://metadata.un.org/sdg/9 Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation |
| description |
The experimental assessment of the linear energy transfer (LET) at micrometric scale with high resolution is mandatory to achieve biologically optimized treatment plans in hadron therapy. Therefore, it is crucial to create active radiation sensors able to quantify microdosimetry distributions in three-dimensions under clinical conditions. We have quantified the first microdosimetry 2D-maps delivered by alpha beams with the highest resolution so far (400 μm × 600 μm) using a customized sensor. It consists of 3 multi-arrays of 50 3 × 3 microdetectors with a pitch of 200 μm that cover a total radiation sensitive area of 9 cm × 0.4 mm. The microdetectors are based on a novel 3D-cylindrical silicon architecture with 25-μm diameter and 20-μm thickness. The back-side of these sensors is etched to avoid back-scattering contributions in heavy ion fields. This system was calibrated with alpha beams from 5.75 to 20 MeV in the Accelerateur Lineaire et Tandem a Orsay (ALTO), France, and irradiated with pulsed beams (from 1.4 μs to 3.3 μs pulse widths) of 7.5 MeV alphas in the Centro de Micro-Analisis de Materiales (CMAM), Spain. We worked with clinical equivalent fluence rates in both continuous irradiation mode (~ 10<sup>8</sup> cm<sup>‒2</sup>s<sup>‒1</sup>) and in pulsed regimes with higher fluence rates up to ~ 10<sup>10</sup> cm<sup>-2</sup>-s<sup>-1</sup>. Measurements of pulse height spectra were collected with the sensor in both modes. The experimental results were crosschecked with Monte Carlo simulations using the GATE code. The simulated spectral shapes and peak positions showed good agreement with the experimental data, with relative differences of less than 3.5% for all the energies studied. Results show that the new microdosimetry array, specially manufactured for ions, is a reliable tool for LET characterization of ions in both continuous and pulsed modes. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2026 2026 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Postprint info:eu-repo/semantics/acceptedVersion |
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article |
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acceptedVersion |
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http://hdl.handle.net/10261/420659 https://api.elsevier.com/content/abstract/scopus_id/105019620714 |
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http://hdl.handle.net/10261/420659 https://api.elsevier.com/content/abstract/scopus_id/105019620714 |
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Inglés |
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Microdosimetry Maps in Continuous and Pulsed Alpha BeamsZhu, YuweiRiera-Llobet, CarlaFleta, CelesteManna, MariaLeite, Amelia MaiaLopez, Gaston GarciaTavora, Vicente GarciaBachiller-Perea, DianaMouchard, QuentinGuardiola Salmerón, Consueloalpha therapyhadron therapymicrodosimetryparticle detectorssilicon microdosimetershttp://metadata.un.org/sdg/9Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovationThe experimental assessment of the linear energy transfer (LET) at micrometric scale with high resolution is mandatory to achieve biologically optimized treatment plans in hadron therapy. Therefore, it is crucial to create active radiation sensors able to quantify microdosimetry distributions in three-dimensions under clinical conditions. We have quantified the first microdosimetry 2D-maps delivered by alpha beams with the highest resolution so far (400 μm × 600 μm) using a customized sensor. It consists of 3 multi-arrays of 50 3 × 3 microdetectors with a pitch of 200 μm that cover a total radiation sensitive area of 9 cm × 0.4 mm. The microdetectors are based on a novel 3D-cylindrical silicon architecture with 25-μm diameter and 20-μm thickness. The back-side of these sensors is etched to avoid back-scattering contributions in heavy ion fields. This system was calibrated with alpha beams from 5.75 to 20 MeV in the Accelerateur Lineaire et Tandem a Orsay (ALTO), France, and irradiated with pulsed beams (from 1.4 μs to 3.3 μs pulse widths) of 7.5 MeV alphas in the Centro de Micro-Analisis de Materiales (CMAM), Spain. We worked with clinical equivalent fluence rates in both continuous irradiation mode (~ 10<sup>8</sup> cm<sup>‒2</sup>s<sup>‒1</sup>) and in pulsed regimes with higher fluence rates up to ~ 10<sup>10</sup> cm<sup>-2</sup>-s<sup>-1</sup>. Measurements of pulse height spectra were collected with the sensor in both modes. The experimental results were crosschecked with Monte Carlo simulations using the GATE code. The simulated spectral shapes and peak positions showed good agreement with the experimental data, with relative differences of less than 3.5% for all the energies studied. Results show that the new microdosimetry array, specially manufactured for ions, is a reliable tool for LET characterization of ions in both continuous and pulsed modes.This work was supported in part by the \u201CTowards Clinical Implementation of Advanced Microdosimetry and Radiobiology for Hadron Therapy\u201D Projects (LabEx P2IO). Consuelo Guardiola thanks the funding from the Proyecto Intramural Especial a (20225AT008) of CSIC. The 3D-cylindrical microdetectors fabrication was funded from the H2020 project AIDA-2020, GA no. 654168. This work made use of the Spanish ICTS Network MICRONANOFABS partially supported by MEINCOM. The work also received funding from project NEWDOSI (PID2021-123484OB-I00), financed by MCIN / AEI / 10.13039/501100011033 / FEDER, UE. Gast\u00F3n Garc\u00EDa L\u00F3pez acknowledges funding by Comunidad de Madrid under projects S2022/BMD-7434 ASAP-CM \u201CAdvanced Strategies and new Approaches for Protontherapy\u201D and PR27/21-014 (pFLASH), and by the Agencia Estatal de Investigaci\u00F3n under projects PLEC2022-009256 \u201CComprendiendo la radioterapia flash con dispositivos de tejido-en-chip y resonancia magn\u00E9tica mejorada con hiperpolarizaci\u00F3n\u201D ?FLASH-on-chip) and PID2021-124094OA-I00 (RADFLAP). (Corresponding author: Consuelo Guardiola). This work did not involve human subjects or animals in its research.Peer reviewedInstitute of Electrical and Electronics EngineersMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)European Commission0000-0002-0100-93600000-0002-9037-15390000-0002-0174-7451Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/420659https://api.elsevier.com/content/abstract/scopus_id/105019620714reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123484OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124094OA-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PLEC2022-009256info:eu-repo/grantAgreement/EC/H2020/1AIDA-2020IEEE Transactions on Radiation and Plasma Medical Scienceshttps://doi.org/10.1109/TRPMS.2025.3620266Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4206592026-05-22T06:33:51Z |
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15,81155 |