Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness

In adult cardiomyocytes, within the Mitochondrial Associated Membranes (MAMs), the sarcoplasmic reticulum (SR) and mitochondria juxtapose each other, forming a unique and highly repetitive functional structure throughout the cells. These SR-mitochondria contact sites have emerged as critical structu...

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Autores: Fernández-Sanz, Celia, Sheu, Shey-Shing, Fuente, Sergio de la
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/422809
Acceso en línea:http://hdl.handle.net/10261/422809
Access Level:acceso abierto
Palabra clave:Heart
MAMs
Mitochondria
Bioenergetics
Microdomains
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spelling Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial FitnessFernández-Sanz, CeliaSheu, Shey-ShingFuente, Sergio de laHeartMAMsMitochondriaBioenergeticsMicrodomainsIn adult cardiomyocytes, within the Mitochondrial Associated Membranes (MAMs), the sarcoplasmic reticulum (SR) and mitochondria juxtapose each other, forming a unique and highly repetitive functional structure throughout the cells. These SR-mitochondria contact sites have emerged as critical structures that regulate various physiological processes, including lipid exchange, calcium (Ca2+) communication, control of excitation-contraction bioenergetics coupling, and reactive oxygen species (ROS) production. Over the years, several scientific studies have reported the accumulation of diverse proteins within these SR-mitochondria close contacts. Some proteins strategically accumulate in these areas to enhance their function, such as the mitochondrial Ca2+ uniporter, while others perform non-canonical roles, such as DRP1 acting as a bioenergetics regulator. The purpose of this review is to provide a comprehensive compilation of the proteins that have been reported to be enriched in cardiac MAMs. We aim to show how their positioning is crucial for proper cardiac physiology and fitness, as well as how mispositioning may contribute to cardiac diseases. Additionally, we will discuss the gaps in our understanding and identify the necessary components to fully comprehend physiological communication between the sarcoplasmic SR and mitochondria in cardiac tissue.C.F.-S. received funding from the American Heart Association—2020 AHA Postdoctoral Fellowship, reference “20POST35211149”. S.-S.S. is supported by NIH 1R01HL137266 and 1R01HL122124. S.D.l.F. received funding from the American Heart Association—2016 AHA Postdoctoral Fellowship, reference “16POST27770032”.Peer reviewedMultidisciplinary Digital Publishing InstituteAmerican Heart AssociationNational Institutes of Health (US)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/422809reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/cells14221762Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4228092026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
title Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
spellingShingle Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
Fernández-Sanz, Celia
Heart
MAMs
Mitochondria
Bioenergetics
Microdomains
title_short Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
title_full Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
title_fullStr Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
title_full_unstemmed Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
title_sort Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness
dc.creator.none.fl_str_mv Fernández-Sanz, Celia
Sheu, Shey-Shing
Fuente, Sergio de la
author Fernández-Sanz, Celia
author_facet Fernández-Sanz, Celia
Sheu, Shey-Shing
Fuente, Sergio de la
author_role author
author2 Sheu, Shey-Shing
Fuente, Sergio de la
author2_role author
author
dc.contributor.none.fl_str_mv American Heart Association
National Institutes of Health (US)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Heart
MAMs
Mitochondria
Bioenergetics
Microdomains
topic Heart
MAMs
Mitochondria
Bioenergetics
Microdomains
description In adult cardiomyocytes, within the Mitochondrial Associated Membranes (MAMs), the sarcoplasmic reticulum (SR) and mitochondria juxtapose each other, forming a unique and highly repetitive functional structure throughout the cells. These SR-mitochondria contact sites have emerged as critical structures that regulate various physiological processes, including lipid exchange, calcium (Ca2+) communication, control of excitation-contraction bioenergetics coupling, and reactive oxygen species (ROS) production. Over the years, several scientific studies have reported the accumulation of diverse proteins within these SR-mitochondria close contacts. Some proteins strategically accumulate in these areas to enhance their function, such as the mitochondrial Ca2+ uniporter, while others perform non-canonical roles, such as DRP1 acting as a bioenergetics regulator. The purpose of this review is to provide a comprehensive compilation of the proteins that have been reported to be enriched in cardiac MAMs. We aim to show how their positioning is crucial for proper cardiac physiology and fitness, as well as how mispositioning may contribute to cardiac diseases. Additionally, we will discuss the gaps in our understanding and identify the necessary components to fully comprehend physiological communication between the sarcoplasmic SR and mitochondria in cardiac tissue.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/422809
url http://hdl.handle.net/10261/422809
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/cells14221762
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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