Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes

Background To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of membranes (PPROM). Methodology/Principal Finding A prospective cohort study was per...

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Autores: Cobo Cobo, Maria Teresa, Kacerovsky, Marian, Palacio, Montse, Hornychova, Helena, Hougaard, David M., Skogstrand, Kristin, Jacobsson, Bo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/125066
Acceso en línea:https://hdl.handle.net/2445/125066
Access Level:acceso abierto
Palabra clave:Inflamació
Neonatologia
Complicacions en l'embaràs
Inflammation
Neonatology
Complications of pregnancy
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spelling Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranesCobo Cobo, Maria TeresaKacerovsky, MarianPalacio, MontseHornychova, HelenaHougaard, David M.Skogstrand, KristinJacobsson, BoInflamacióNeonatologiaComplicacions en l'embaràsInflammationNeonatologyComplications of pregnancyBackground To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of membranes (PPROM). Methodology/Principal Finding A prospective cohort study was performed in 107 women with PPROM between 23.0 and 36.6 weeks of gestational age. Twenty-six proteins were assayed by multiple immunoassay in amniotic fluid. The policy for PPROM in Czech Republic is active, and 90% of the women were delivered within 96 hours of membrane rupture. Histopathological placental findings were evaluated based on the Salafia classification. Data were analyzed in four subgroups of population according to the presence of MIAC and/or HCA. Results were stratified by gestational age at PPROM (< or ≥34.0 weeks). The rates of MIAC and HCA were 44% and 57%, respectively. Regardless of gestational age at PPROM, intra-amniotic inflammatory response was higher when MIAC and HCA were both present. There were no differences in the intra-amniotic inflammatory response between women with MIAC or HCA alone and women without infection. Conclusion A higher intra-amniotic inflammatory response was identified when both HCA and MIAC were detected.Public Library of Science (PLoS)2018201820122018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/125066Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0043677PLoS One, 2012, vol. 7, num. 8, p. e43677https://doi.org/10.1371/journal.pone.0043677cc-by (c) Cobo Cobo, María Teresa et al., 2012http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1250662026-05-29T05:05:01Z
dc.title.none.fl_str_mv Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
title Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
spellingShingle Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
Cobo Cobo, Maria Teresa
Inflamació
Neonatologia
Complicacions en l'embaràs
Inflammation
Neonatology
Complications of pregnancy
title_short Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
title_full Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
title_fullStr Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
title_full_unstemmed Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
title_sort Intra-amniotic inflammatory response in subgroups of women with preterm prelabor rupture of the membranes
dc.creator.none.fl_str_mv Cobo Cobo, Maria Teresa
Kacerovsky, Marian
Palacio, Montse
Hornychova, Helena
Hougaard, David M.
Skogstrand, Kristin
Jacobsson, Bo
author Cobo Cobo, Maria Teresa
author_facet Cobo Cobo, Maria Teresa
Kacerovsky, Marian
Palacio, Montse
Hornychova, Helena
Hougaard, David M.
Skogstrand, Kristin
Jacobsson, Bo
author_role author
author2 Kacerovsky, Marian
Palacio, Montse
Hornychova, Helena
Hougaard, David M.
Skogstrand, Kristin
Jacobsson, Bo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Inflamació
Neonatologia
Complicacions en l'embaràs
Inflammation
Neonatology
Complications of pregnancy
topic Inflamació
Neonatologia
Complicacions en l'embaràs
Inflammation
Neonatology
Complications of pregnancy
description Background To evaluate the influence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) on the magnitude of intra-amniotic inflammatory response in preterm prelabor rupture of membranes (PPROM). Methodology/Principal Finding A prospective cohort study was performed in 107 women with PPROM between 23.0 and 36.6 weeks of gestational age. Twenty-six proteins were assayed by multiple immunoassay in amniotic fluid. The policy for PPROM in Czech Republic is active, and 90% of the women were delivered within 96 hours of membrane rupture. Histopathological placental findings were evaluated based on the Salafia classification. Data were analyzed in four subgroups of population according to the presence of MIAC and/or HCA. Results were stratified by gestational age at PPROM (< or ≥34.0 weeks). The rates of MIAC and HCA were 44% and 57%, respectively. Regardless of gestational age at PPROM, intra-amniotic inflammatory response was higher when MIAC and HCA were both present. There were no differences in the intra-amniotic inflammatory response between women with MIAC or HCA alone and women without infection. Conclusion A higher intra-amniotic inflammatory response was identified when both HCA and MIAC were detected.
publishDate 2012
dc.date.none.fl_str_mv 2012
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125066
url https://hdl.handle.net/2445/125066
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0043677
PLoS One, 2012, vol. 7, num. 8, p. e43677
https://doi.org/10.1371/journal.pone.0043677
dc.rights.none.fl_str_mv cc-by (c) Cobo Cobo, María Teresa et al., 2012
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Cobo Cobo, María Teresa et al., 2012
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421930243686400
score 15,198674

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