Wnt controls the medial -lateral subdivision of the Drosophila head

© 2018 The Authors.

Detalles Bibliográficos
Autores: Magri, Marta Silvia, Domínguez-Cejudo, María A., Casares, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/242586
Acceso en línea:http://hdl.handle.net/10261/242586
Access Level:acceso abierto
Palabra clave:Wnt
Insect head
Drosophila
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oai_identifier_str oai:digital.csic.es:10261/242586
network_acronym_str ES
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repository_id_str
spelling Wnt controls the medial -lateral subdivision of the Drosophila headMagri, Marta SilviaDomínguez-Cejudo, María A.Casares, FernandoWntInsect headDrosophila© 2018 The Authors.In insects, the subdivision of the head into a lateral region, harbouring the compound eyes (CEs), and a dorsal (medial) region, where the ocelli localize, is conserved. This organization might have been already present in the insects' euarthropodan ancestors. In Drosophila, the Wnt-1 homologue wingless (wg) plays a major role in the genetic subdivision of the head. To analyse specifically the role of wg signalling in the development of the dorsal head, we attenuated this pathway specifically in this region by genetic means. We find that loss of wg signalling transforms the dorsal/medial head into lateral head structures, including the development of ectopic CEs. Our genetic analysis further suggests that wg signalling organizes the dorsal head medial–lateral axis by controlling, at least in part, the expression domains of the transcription factors Otd and Ey/Pax6.This work was supported by MINECO (Spain) through grant nos. BFU2015-66040-P (to F.C.) and MDM-2016-0687.Royal Society (Great Britain)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120182021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/242586reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-66040-Pinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2016-0687http://dx.doi.org/10.1098/rsbl.2018.0258Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2425862026-05-22T06:33:51Z
dc.title.none.fl_str_mv Wnt controls the medial -lateral subdivision of the Drosophila head
title Wnt controls the medial -lateral subdivision of the Drosophila head
spellingShingle Wnt controls the medial -lateral subdivision of the Drosophila head
Magri, Marta Silvia
Wnt
Insect head
Drosophila
title_short Wnt controls the medial -lateral subdivision of the Drosophila head
title_full Wnt controls the medial -lateral subdivision of the Drosophila head
title_fullStr Wnt controls the medial -lateral subdivision of the Drosophila head
title_full_unstemmed Wnt controls the medial -lateral subdivision of the Drosophila head
title_sort Wnt controls the medial -lateral subdivision of the Drosophila head
dc.creator.none.fl_str_mv Magri, Marta Silvia
Domínguez-Cejudo, María A.
Casares, Fernando
author Magri, Marta Silvia
author_facet Magri, Marta Silvia
Domínguez-Cejudo, María A.
Casares, Fernando
author_role author
author2 Domínguez-Cejudo, María A.
Casares, Fernando
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Wnt
Insect head
Drosophila
topic Wnt
Insect head
Drosophila
description © 2018 The Authors.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/242586
url http://hdl.handle.net/10261/242586
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-66040-P
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2016-0687
http://dx.doi.org/10.1098/rsbl.2018.0258
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society (Great Britain)
publisher.none.fl_str_mv Royal Society (Great Britain)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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