Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old

Invasive pneumococcal disease (IPD) presents high mortality in the population at risk. The aim of this work is to know the evolution, clinical and microbiological characteristics of IPD in the adult population of Majorca, since the introduction of a public funded program for pneumococcal conjugate v...

Descripción completa

Detalles Bibliográficos
Autores: Bonilla, Alfonso, Losada-López, Inés, González-Moreno, Juan, Penaranda, Maria, Vilaplana, Laia, Roda, Nuria, Rey, Adelaida, Rodríguez, Adrián, Garau Colom, Maria Margarita, Ruiz de Gopegui-Bordes, Enrique, Serra, Antoni, Saurina, Juan, Payeras, Antoni
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23268
Acceso en línea:https://hdl.handle.net/20.500.12105/23268
Access Level:acceso abierto
Palabra clave:Pneumococcal disease
Invasive pneumococcal disease
Pneumococcal conjugate vaccine
Serotypes
Antibiotic sensitivity
id ES_dde09be060fb55ae03341b15cbee4fd0
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/23268
network_acronym_str ES
network_name_str España
repository_id_str
spelling Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years OldBonilla, AlfonsoLosada-López, InésGonzález-Moreno, JuanPenaranda, MariaVilaplana, LaiaRoda, NuriaRey, AdelaidaRodríguez, AdriánGarau Colom, Maria MargaritaRuiz de Gopegui-Bordes, EnriqueSerra, AntoniSaurina, JuanPayeras, AntoniPneumococcal diseaseInvasive pneumococcal diseasePneumococcal conjugate vaccineSerotypesAntibiotic sensitivityInvasive pneumococcal disease (IPD) presents high mortality in the population at risk. The aim of this work is to know the evolution, clinical and microbiological characteristics of IPD in the adult population of Majorca, since the introduction of a public funded program for pneumococcal conjugate vaccine (PCV-13) in the pediatric population in the Balearic Islands in 2016. For this purpose, a retrospective multicenter study was carried out in which all episodes of IPD in adult patients from the four hospitals of the public health system of Majorca were included, comparing the periods between 2012 and 2015 and between 2016 and 2019. Clinical variables, serotypes and antibiotic sensitivity were collected. There were 498 cases of IPD; 56.8% were male with a mean age of 67 (standard deviation: 16). Most infections were bacterial pneumonias (73.7%). of the total cases, 264 (53%) presented complications. of the 498 cases, 351 strains were obtained, of which 145 (41.3%) belong to vaccinal serotypes (included in the PCV-13 vaccine) and 206 (58.7%) to non-vaccinal serotypes (not included in the PCV-13 vaccine). The percentage of IPD caused by vaccinal serotypes was lower in the second period (47.8% vs. 34.5%; p = 0.012).Multidisciplinary Digital Publishing Institute (MDPI)20242024-09-1820212021-02-0120212021-02-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23268reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/232682026-06-12T12:43:37Z
dc.title.none.fl_str_mv Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
title Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
spellingShingle Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
Bonilla, Alfonso
Pneumococcal disease
Invasive pneumococcal disease
Pneumococcal conjugate vaccine
Serotypes
Antibiotic sensitivity
title_short Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
title_full Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
title_fullStr Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
title_full_unstemmed Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
title_sort Evolution, Clinical and Microbiological Characteristics of Invasive Pneumococcal Disease since the Introduction of the Pneumococcal Conjugate Vaccine 13-Valent in Adults over 18 Years Old
dc.creator.none.fl_str_mv Bonilla, Alfonso
Losada-López, Inés
González-Moreno, Juan
Penaranda, Maria
Vilaplana, Laia
Roda, Nuria
Rey, Adelaida
Rodríguez, Adrián
Garau Colom, Maria Margarita
Ruiz de Gopegui-Bordes, Enrique
Serra, Antoni
Saurina, Juan
Payeras, Antoni
author Bonilla, Alfonso
author_facet Bonilla, Alfonso
Losada-López, Inés
González-Moreno, Juan
Penaranda, Maria
Vilaplana, Laia
Roda, Nuria
Rey, Adelaida
Rodríguez, Adrián
Garau Colom, Maria Margarita
Ruiz de Gopegui-Bordes, Enrique
Serra, Antoni
Saurina, Juan
Payeras, Antoni
author_role author
author2 Losada-López, Inés
González-Moreno, Juan
Penaranda, Maria
Vilaplana, Laia
Roda, Nuria
Rey, Adelaida
Rodríguez, Adrián
Garau Colom, Maria Margarita
Ruiz de Gopegui-Bordes, Enrique
Serra, Antoni
Saurina, Juan
Payeras, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Pneumococcal disease
Invasive pneumococcal disease
Pneumococcal conjugate vaccine
Serotypes
Antibiotic sensitivity
topic Pneumococcal disease
Invasive pneumococcal disease
Pneumococcal conjugate vaccine
Serotypes
Antibiotic sensitivity
description Invasive pneumococcal disease (IPD) presents high mortality in the population at risk. The aim of this work is to know the evolution, clinical and microbiological characteristics of IPD in the adult population of Majorca, since the introduction of a public funded program for pneumococcal conjugate vaccine (PCV-13) in the pediatric population in the Balearic Islands in 2016. For this purpose, a retrospective multicenter study was carried out in which all episodes of IPD in adult patients from the four hospitals of the public health system of Majorca were included, comparing the periods between 2012 and 2015 and between 2016 and 2019. Clinical variables, serotypes and antibiotic sensitivity were collected. There were 498 cases of IPD; 56.8% were male with a mean age of 67 (standard deviation: 16). Most infections were bacterial pneumonias (73.7%). of the total cases, 264 (53%) presented complications. of the 498 cases, 351 strains were obtained, of which 145 (41.3%) belong to vaccinal serotypes (included in the PCV-13 vaccine) and 206 (58.7%) to non-vaccinal serotypes (not included in the PCV-13 vaccine). The percentage of IPD caused by vaccinal serotypes was lower in the second period (47.8% vs. 34.5%; p = 0.012).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-02-01
2021
2021-02-01
2024
2024-09-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23268
url https://hdl.handle.net/20.500.12105/23268
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421923137486848
score 15.81155

Similares en LA Referencia