Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study

Background/Objectives: This study aimed to examine the association between leukocyte telomere length (TL) measured at ages 4 and 8 and emotional and behavioral problems at age 8. We also explored whether changes in leukocyte TL between ages 4 and 8 were associated with outcomes. Methods: Data were o...

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Autores: Campos Sánchez, Irene, Navarrete-Muñoz, Eva María, Barber-Valles, Josep Xavier, Martens, Dries S., Riaño Galán, Isolina, Irizar, Amaia, Llop, Sabrina, Guxens Junyent, Mònica, Rodríguez Dehli, Cristina, Babarro, Izaro, Lozano, Manuel, Vrijheid, Martine, Nawrot, Tim S., Valera-Gran, Desirée
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/71169
Acceso en línea:http://hdl.handle.net/10230/71169
http://dx.doi.org/10.3390/children12070875
Access Level:acceso abierto
Palabra clave:Telomere length
Emotional problems
Behavioral problems
Internalizing problems
Externalizing problems
Childhood
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dc.title.none.fl_str_mv Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
title Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
spellingShingle Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
Campos Sánchez, Irene
Telomere length
Emotional problems
Behavioral problems
Internalizing problems
Externalizing problems
Childhood
title_short Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
title_full Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
title_fullStr Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
title_full_unstemmed Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
title_sort Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) study
dc.creator.none.fl_str_mv Campos Sánchez, Irene
Navarrete-Muñoz, Eva María
Barber-Valles, Josep Xavier
Martens, Dries S.
Riaño Galán, Isolina
Irizar, Amaia
Llop, Sabrina
Guxens Junyent, Mònica
Rodríguez Dehli, Cristina
Babarro, Izaro
Lozano, Manuel
Vrijheid, Martine
Nawrot, Tim S.
Valera-Gran, Desirée
author Campos Sánchez, Irene
author_facet Campos Sánchez, Irene
Navarrete-Muñoz, Eva María
Barber-Valles, Josep Xavier
Martens, Dries S.
Riaño Galán, Isolina
Irizar, Amaia
Llop, Sabrina
Guxens Junyent, Mònica
Rodríguez Dehli, Cristina
Babarro, Izaro
Lozano, Manuel
Vrijheid, Martine
Nawrot, Tim S.
Valera-Gran, Desirée
author_role author
author2 Navarrete-Muñoz, Eva María
Barber-Valles, Josep Xavier
Martens, Dries S.
Riaño Galán, Isolina
Irizar, Amaia
Llop, Sabrina
Guxens Junyent, Mònica
Rodríguez Dehli, Cristina
Babarro, Izaro
Lozano, Manuel
Vrijheid, Martine
Nawrot, Tim S.
Valera-Gran, Desirée
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Telomere length
Emotional problems
Behavioral problems
Internalizing problems
Externalizing problems
Childhood
topic Telomere length
Emotional problems
Behavioral problems
Internalizing problems
Externalizing problems
Childhood
description Background/Objectives: This study aimed to examine the association between leukocyte telomere length (TL) measured at ages 4 and 8 and emotional and behavioral problems at age 8. We also explored whether changes in leukocyte TL between ages 4 and 8 were associated with outcomes. Methods: Data were obtained from a population-based birth cohort and included 647 children with TL at age 4 and emotional and behavioral assessments at age 8, 673 with TL and outcomes at age 8, and 315 with TL measured at both ages. TL was determined using quantitative PCR on blood samples and converted into z-scores for analysis. Emotional and behavioral problems—including internalizing, externalizing, and total difficulties—were assessed using the Strengths and Difficulties Questionnaire. Regression models were conducted using zero-inflated and negative binomial, adjusting for sociodemographic and lifestyle covariates. Results: No statistically significant associations were observed between leukocyte TL at ages 4 or 8, or TL changes over this period, and emotional and behavioral outcomes at age 8. Conclusions: Although no significant associations were found, further longitudinal research is warranted to clarify the role of TL as a potential psychobiomarker of emotional and behavioral disorders in childhood.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/71169
http://dx.doi.org/10.3390/children12070875
url http://hdl.handle.net/10230/71169
http://dx.doi.org/10.3390/children12070875
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Children. 2025 Jul;12(7):875
info:eu-repo/grantAgreement/EC/FP7/282957
info:eu-repo/grantAgreement/ES/CEX2018-000806-S/
info:eu-repo/grantAgreement/EC/H2020/874583
info:eu-repo/grantAgreement/EC/H2020/261357
info:eu-repo/grantAgreement/EC/H2020/308333
info:eu-repo/grantAgreement/EC/H2020/603794
info:eu-repo/grantAgreement/EC/H2020/634453
info:eu-repo/grantAgreement/EC/H2020/101136566
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info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
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spelling Telomere length and emotional and behavioral problems in children from the prospective birth cohort Infancia y Medio Ambiente (INMA) studyCampos Sánchez, Irene Navarrete-Muñoz, Eva MaríaBarber-Valles, Josep XavierMartens, Dries S.Riaño Galán, IsolinaIrizar, AmaiaLlop, SabrinaGuxens Junyent, MònicaRodríguez Dehli, CristinaBabarro, IzaroLozano, ManuelVrijheid, MartineNawrot, Tim S.Valera-Gran, DesiréeTelomere lengthEmotional problemsBehavioral problemsInternalizing problemsExternalizing problemsChildhoodBackground/Objectives: This study aimed to examine the association between leukocyte telomere length (TL) measured at ages 4 and 8 and emotional and behavioral problems at age 8. We also explored whether changes in leukocyte TL between ages 4 and 8 were associated with outcomes. Methods: Data were obtained from a population-based birth cohort and included 647 children with TL at age 4 and emotional and behavioral assessments at age 8, 673 with TL and outcomes at age 8, and 315 with TL measured at both ages. TL was determined using quantitative PCR on blood samples and converted into z-scores for analysis. Emotional and behavioral problems—including internalizing, externalizing, and total difficulties—were assessed using the Strengths and Difficulties Questionnaire. Regression models were conducted using zero-inflated and negative binomial, adjusting for sociodemographic and lifestyle covariates. Results: No statistically significant associations were observed between leukocyte TL at ages 4 or 8, or TL changes over this period, and emotional and behavioral outcomes at age 8. Conclusions: Although no significant associations were found, further longitudinal research is warranted to clarify the role of TL as a potential psychobiomarker of emotional and behavioral disorders in childhood.This research was funded by the Instituto de Salud Carlos III/Agencia Estatal de Investigación (PI18/00825) about the Project: “Diet and physical activity in pregnancy and after birth and telomere length in children and adolescents: TeloDiPA Project”; the Department of Innovation, Universities, Science and Digital Society of Valencian Community for the Project “Telomere length and neuropsychological development between 4 and 8 years: TeloNeuro Project (GVA/2021/191)”; and Irene Campos-Sánchez has a grant from the ministry of universities of Spain “Ayuda a la formación de profesorado Universitario (FPU21/01323)” and award for research by young research personnel (Edition 2023, Manel Nebot) by the Spanish Society of Epidemiology. Dries Martens holds a postdoctoral grant from the Research Foundation Flanders (FWO grant 12X9623N). INMA Asturias was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), FIS-PI042018 incl. FEDER funds, FIS-PI09/02311 incl. FEDER funds, FIS-PI13/02429 incl. FEDER funds, FIS-PI18/00909 incl. FEDER funds, CIBERESP, Obra Social Cajastur/Fundación Liberbank, and Universidad de Oviedo. INMA Gipuzkoa was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187, FIS-PI18/01142 including FEDER funds, and FIS-PI18/01237 incl. FEDER funds), CIBERESP, the Department of Health of the Basque Government (2005111093, 2009111069, 2013111089, 2015111065, and 2018111086), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001, DFG15/221, and DFG 89/17) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia, Azpeitia, Beasain). INMA-Sabadell was supported by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010), and EU Commission (261357, 308333, 603794, and 634453). We acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and support from the Generalitat de Catalunya through the CERCA Program. INMA Valencia was supported by Grants from UE (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, code 874583, and code 101136566), Spain: ISCIII (G03/176; FIS-FEDER: PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI19/1338; PI23/1578), Miguel Servet-FEDER CP11/00178, CP15/00025, MSII16/00051, MS20/0006), Spanish Ministry of Universities (Margarita Salas Grant MS21-133, grant CAS21/00008, NextGeneration EU), Generalitat Valenciana (CIAICO/2021/132, BEST/2020/059, AICO 2020/285, AICO/2021/182 and CIDEGENT/2019/064), Consejo General de Enfermería (PNI22_CGE45), FISABIO (UGP 15-230, UGP-15-244, UGP-15-249), and Alicia Koplowitz Foundation 2017.MDPI202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/71169http://dx.doi.org/10.3390/children12070875reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésChildren. 2025 Jul;12(7):875info:eu-repo/grantAgreement/EC/FP7/282957info:eu-repo/grantAgreement/ES/CEX2018-000806-S/info:eu-repo/grantAgreement/EC/H2020/874583info:eu-repo/grantAgreement/EC/H2020/261357info:eu-repo/grantAgreement/EC/H2020/308333info:eu-repo/grantAgreement/EC/H2020/603794info:eu-repo/grantAgreement/EC/H2020/634453info:eu-repo/grantAgreement/EC/H2020/101136566© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/711692026-06-12T07:21:37Z
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