Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.

Mogna-Peláez, Paola; Riezu-Boj, José I; Milagro, Fermin I; Herrero, José I; Elorz, Mariana; Benito-Boillos, Alberto; Tobaruela-Resola, Ana Luz; Tur, Josep A.; Martínez, J Alfredo; Abete, Itziar; Zulet, M Angeles

Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern. The disease is silent, and its diagnosis is often delayed. Inflammatory markers constitute an interesting tool to act as subrogate, non-invasive markers. This study aimed to evaluate the changes of i...

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Detalhes bibliográficos
Autores:	Mogna-Peláez, Paola, Riezu-Boj, José I, Milagro, Fermin I, Herrero, José I, Elorz, Mariana, Benito-Boillos, Alberto, Tobaruela-Resola, Ana Luz, Tur, Josep A., Martínez, J Alfredo, Abete, Itziar, Zulet, M Angeles
Formato:	artículo
Fecha de publicación:	2024
País:	España
Recursos:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:	Docusalut
Idioma:	inglés
OAI Identifier:	oai:docusalut.com:20.500.13003/20596
Acesso em linha:	https://hdl.handle.net/20.500.13003/20596
Access Level:	acceso abierto
Palavra-chave:	Adult Humans Inflammation Middle Aged Non-alcoholic Fatty Liver Disease Obesity Fatty Liver Male Liver Biomarkers Leptin Female Diet, Mediterranean Dieta Mediterránea Biomarcadores Femenino Enfermedad del Hígado Graso no Alcohólico Masculino Hígado Hígado Graso Obesidad Humanos Persona de Mediana Edad Inflamación Adulto Leptina

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spelling	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.Mogna-Peláez, PaolaRiezu-Boj, José IMilagro, Fermin IHerrero, José IElorz, MarianaBenito-Boillos, AlbertoTobaruela-Resola, Ana LuzTur, Josep A.Martínez, J AlfredoAbete, ItziarZulet, M AngelesAdultHumansInflammationMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityFatty LiverMaleLiverBiomarkersLeptinFemaleDiet, MediterraneanDieta MediterráneaBiomarcadoresFemeninoEnfermedad del Hígado Graso no AlcohólicoMasculinoHígadoHígado GrasoObesidadHumanosPersona de Mediana EdadInflamaciónAdultoLeptinaMetabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern. The disease is silent, and its diagnosis is often delayed. Inflammatory markers constitute an interesting tool to act as subrogate, non-invasive markers. This study aimed to evaluate the changes of inflammatory markers throughout a two-year dietary intervention in subjects presenting MASLD, to determine which of the markers are suitable to predict the disease, and act as a customizing tool for MASLD's dietary treatment. Ninety-eight subjects with MASLD and forty-five controls from the Fatty Liver in Obesity (FLiO) Study were analyzed. MASLD was diagnosed and graded by ultrasound. The MASLD subjects were randomly assigned to two different dietary strategies, the American Heart Association (AHA diet) or a dietary strategy based on the Mediterranean pattern, which was specially designed for the study (FLiO diet), and then followed for two years. Hepatic status was additionally assessed through Magnetic Resonance Imaging (MRI), elastography, and determination of transaminases. Inflammatory markers improved throughout the intervention in the MASLD subjects and managed to reach similar levels to controls, especially at 6 and 12 months. Additionally, leptin, adiponectin, M30, and LECT2 managed to significantly diagnose the disease at all time marks of the intervention, making them candidates for subrogate non-invasive markers of the disease. Moreover, baseline chemerin, leptin, LECT2, and M65 were used to build a predictive score to achieve greater weight loss, and therefore, which strategy could be more useful for MASLD 's treatment. The predictive score was significantly able assign a specific diet to 55% of the study participants, meaning that the remaining 45% could achieve the same amount of weight loss following either diet equally. Inflammatory markers constitute a potential non-invasive tool to be used in MASLD screening and could also constitute an interesting tool for MASLD's treatment customization, being able to predict the effectiveness of a dietary strategy based on the initial inflammatory state of each subject. www. gov (NCT03183193).Elsevier20242024-07-0120242024-07-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/20596reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/205962026-06-22T12:44:07Z
dc.title.none.fl_str_mv	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.
title	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.
spellingShingle	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial. Mogna-Peláez, Paola Adult Humans Inflammation Middle Aged Non-alcoholic Fatty Liver Disease Obesity Fatty Liver Male Liver Biomarkers Leptin Female Diet, Mediterranean Dieta Mediterránea Biomarcadores Femenino Enfermedad del Hígado Graso no Alcohólico Masculino Hígado Hígado Graso Obesidad Humanos Persona de Mediana Edad Inflamación Adulto Leptina
title_short	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.
title_full	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.
title_fullStr	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.
title_full_unstemmed	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.
title_sort	Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.
dc.creator.none.fl_str_mv	Mogna-Peláez, Paola Riezu-Boj, José I Milagro, Fermin I Herrero, José I Elorz, Mariana Benito-Boillos, Alberto Tobaruela-Resola, Ana Luz Tur, Josep A. Martínez, J Alfredo Abete, Itziar Zulet, M Angeles
author	Mogna-Peláez, Paola
author_facet	Mogna-Peláez, Paola Riezu-Boj, José I Milagro, Fermin I Herrero, José I Elorz, Mariana Benito-Boillos, Alberto Tobaruela-Resola, Ana Luz Tur, Josep A. Martínez, J Alfredo Abete, Itziar Zulet, M Angeles
author_role	author
author2	Riezu-Boj, José I Milagro, Fermin I Herrero, José I Elorz, Mariana Benito-Boillos, Alberto Tobaruela-Resola, Ana Luz Tur, Josep A. Martínez, J Alfredo Abete, Itziar Zulet, M Angeles
author2_role	author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Adult Humans Inflammation Middle Aged Non-alcoholic Fatty Liver Disease Obesity Fatty Liver Male Liver Biomarkers Leptin Female Diet, Mediterranean Dieta Mediterránea Biomarcadores Femenino Enfermedad del Hígado Graso no Alcohólico Masculino Hígado Hígado Graso Obesidad Humanos Persona de Mediana Edad Inflamación Adulto Leptina
topic	Adult Humans Inflammation Middle Aged Non-alcoholic Fatty Liver Disease Obesity Fatty Liver Male Liver Biomarkers Leptin Female Diet, Mediterranean Dieta Mediterránea Biomarcadores Femenino Enfermedad del Hígado Graso no Alcohólico Masculino Hígado Hígado Graso Obesidad Humanos Persona de Mediana Edad Inflamación Adulto Leptina
description	Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern. The disease is silent, and its diagnosis is often delayed. Inflammatory markers constitute an interesting tool to act as subrogate, non-invasive markers. This study aimed to evaluate the changes of inflammatory markers throughout a two-year dietary intervention in subjects presenting MASLD, to determine which of the markers are suitable to predict the disease, and act as a customizing tool for MASLD's dietary treatment. Ninety-eight subjects with MASLD and forty-five controls from the Fatty Liver in Obesity (FLiO) Study were analyzed. MASLD was diagnosed and graded by ultrasound. The MASLD subjects were randomly assigned to two different dietary strategies, the American Heart Association (AHA diet) or a dietary strategy based on the Mediterranean pattern, which was specially designed for the study (FLiO diet), and then followed for two years. Hepatic status was additionally assessed through Magnetic Resonance Imaging (MRI), elastography, and determination of transaminases. Inflammatory markers improved throughout the intervention in the MASLD subjects and managed to reach similar levels to controls, especially at 6 and 12 months. Additionally, leptin, adiponectin, M30, and LECT2 managed to significantly diagnose the disease at all time marks of the intervention, making them candidates for subrogate non-invasive markers of the disease. Moreover, baseline chemerin, leptin, LECT2, and M65 were used to build a predictive score to achieve greater weight loss, and therefore, which strategy could be more useful for MASLD 's treatment. The predictive score was significantly able assign a specific diet to 55% of the study participants, meaning that the remaining 45% could achieve the same amount of weight loss following either diet equally. Inflammatory markers constitute a potential non-invasive tool to be used in MASLD screening and could also constitute an interesting tool for MASLD's treatment customization, being able to predict the effectiveness of a dietary strategy based on the initial inflammatory state of each subject. www. gov (NCT03183193).
publishDate	2024
dc.date.none.fl_str_mv	2024 2024-07-01 2024 2024-07-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/20596
url	https://hdl.handle.net/20.500.13003/20596
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial.

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