Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder

Introduction: Sleep problems are prevalent among individuals with autism spectrum disorder (ASD), and a role has been attributed to melatonin in this multifactorial comorbidity. Methods: A cross-sectional study was conducted on 41 autistic children and adolescents (9.9 ± 3.02) and 24 children and ad...

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Detalhes bibliográficos
Autores: Martinez-Cayuelas, Elena, Gavela-Pérez, Teresa, Rodrigo-Moreno, María, Merino-Andreu, Milagros, Vales-Villamarín, Claudia, Pérez-Nadador, Iris, Garcés, Carmen, Soriano Guillén, Leandro
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/718438
Acesso em linha:http://hdl.handle.net/10486/718438
https://dx.doi.org/10.3389/fneur.2022.813692
Access Level:acceso abierto
Palavra-chave:actigraphy
autism spectrum disorder
circadian rhythm
melatonin
puberty
slee
Medicina
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spelling Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum DisorderMartinez-Cayuelas, ElenaGavela-Pérez, TeresaRodrigo-Moreno, MaríaMerino-Andreu, MilagrosVales-Villamarín, ClaudiaPérez-Nadador, IrisGarcés, CarmenSoriano Guillén, Leandroactigraphyautism spectrum disordercircadian rhythmmelatoninpubertysleeMedicinaIntroduction: Sleep problems are prevalent among individuals with autism spectrum disorder (ASD), and a role has been attributed to melatonin in this multifactorial comorbidity. Methods: A cross-sectional study was conducted on 41 autistic children and adolescents (9.9 ± 3.02) and 24 children and adolescents with a normal intellectual function (8.42 ± 2.43) were used as controls. Subjects were matched for sex, body mass index, and pubertal stage, and all were drug-naive. Circadian and sleep parameters were studied using an ambulatory circadian monitoring (ACM) device, and saliva samples were collected around the onset of sleep to determine dim light melatonin onset (DLMO). Results: Prepubertal individuals with ASD presented later DLMO and an earlier decline in melatonin during adolescence. A relationship was found between melatonin and both sleep and circadian parameters. Participants and controls with later DLMOs were more likely to have delayed sleep onset times. In the ASD group, subjects with the later daytime midpoint of temperature had a later DLMO. Later melatonin peak time and DLMO time were related to lower general motor activity and lower stability of its rhythms. Conclusion: The melatonin secretion pattern was different in individuals with ASD, and it showed a relationship with sleep and circadian parameters. Alterations in DLMO have not been previously reported in ASD with the exception of more variable DLMO timing; however, high variability in the study design and sample characteristics prevents direct comparison. The ACM device enabled the measurement of circadian rhythm, a scarcely described parameter in autistic children. When studied in combination with other measures such as melatonin, ACM can offer further knowledge on sleep problems in ASDFrontiers MediaDepartamento de Pediatría20222022-06-14research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/718438https://dx.doi.org/10.3389/fneur.2022.813692reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7184382026-06-23T12:46:27Z
dc.title.none.fl_str_mv Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
title Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
spellingShingle Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
Martinez-Cayuelas, Elena
actigraphy
autism spectrum disorder
circadian rhythm
melatonin
puberty
slee
Medicina
title_short Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
title_full Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
title_fullStr Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
title_full_unstemmed Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
title_sort Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder
dc.creator.none.fl_str_mv Martinez-Cayuelas, Elena
Gavela-Pérez, Teresa
Rodrigo-Moreno, María
Merino-Andreu, Milagros
Vales-Villamarín, Claudia
Pérez-Nadador, Iris
Garcés, Carmen
Soriano Guillén, Leandro
author Martinez-Cayuelas, Elena
author_facet Martinez-Cayuelas, Elena
Gavela-Pérez, Teresa
Rodrigo-Moreno, María
Merino-Andreu, Milagros
Vales-Villamarín, Claudia
Pérez-Nadador, Iris
Garcés, Carmen
Soriano Guillén, Leandro
author_role author
author2 Gavela-Pérez, Teresa
Rodrigo-Moreno, María
Merino-Andreu, Milagros
Vales-Villamarín, Claudia
Pérez-Nadador, Iris
Garcés, Carmen
Soriano Guillén, Leandro
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Pediatría
dc.subject.none.fl_str_mv actigraphy
autism spectrum disorder
circadian rhythm
melatonin
puberty
slee
Medicina
topic actigraphy
autism spectrum disorder
circadian rhythm
melatonin
puberty
slee
Medicina
description Introduction: Sleep problems are prevalent among individuals with autism spectrum disorder (ASD), and a role has been attributed to melatonin in this multifactorial comorbidity. Methods: A cross-sectional study was conducted on 41 autistic children and adolescents (9.9 ± 3.02) and 24 children and adolescents with a normal intellectual function (8.42 ± 2.43) were used as controls. Subjects were matched for sex, body mass index, and pubertal stage, and all were drug-naive. Circadian and sleep parameters were studied using an ambulatory circadian monitoring (ACM) device, and saliva samples were collected around the onset of sleep to determine dim light melatonin onset (DLMO). Results: Prepubertal individuals with ASD presented later DLMO and an earlier decline in melatonin during adolescence. A relationship was found between melatonin and both sleep and circadian parameters. Participants and controls with later DLMOs were more likely to have delayed sleep onset times. In the ASD group, subjects with the later daytime midpoint of temperature had a later DLMO. Later melatonin peak time and DLMO time were related to lower general motor activity and lower stability of its rhythms. Conclusion: The melatonin secretion pattern was different in individuals with ASD, and it showed a relationship with sleep and circadian parameters. Alterations in DLMO have not been previously reported in ASD with the exception of more variable DLMO timing; however, high variability in the study design and sample characteristics prevents direct comparison. The ACM device enabled the measurement of circadian rhythm, a scarcely described parameter in autistic children. When studied in combination with other measures such as melatonin, ACM can offer further knowledge on sleep problems in ASD
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-06-14
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/718438
https://dx.doi.org/10.3389/fneur.2022.813692
url http://hdl.handle.net/10486/718438
https://dx.doi.org/10.3389/fneur.2022.813692
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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