Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma
Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/63093 |
| Acceso en línea: | https://hdl.handle.net/10171/63093 |
| Access Level: | acceso abierto |
| Palabra clave: | Lymphoplasmacytic lymphoma Mutations MYD88 |
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Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma |
| title |
Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma |
| spellingShingle |
Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma Rodríguez-Díaz, S. (Saray)|||/items/dbb02193-b704-4400-bed5-3eb2b5518a0b Lymphoplasmacytic lymphoma Mutations MYD88 |
| title_short |
Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma |
| title_full |
Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma |
| title_fullStr |
Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma |
| title_full_unstemmed |
Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma |
| title_sort |
Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphoma |
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Rodríguez-Díaz, S. (Saray)|||/items/dbb02193-b704-4400-bed5-3eb2b5518a0b Celay-Leoz, I. (Ion)|||/items/2e6e988c-469d-484c-8d81-709e742b9cdc Goicoechea, I. (Ibai)|||/items/544dc017-de06-44f7-b32f-9279f853d817 Jiménez, C. (Cristina)|||/items/dc078094-0995-4678-aafa-3fbb8928bef5 Botta, C. (Cirino)|||/items/52fa96dc-28b2-4e6e-b74a-bc804c280646 García-Barchino, M.J. (María José)|||/items/a05fe752-64c5-4987-9f83-5bf26c3a26a6 Garcés-Latre, J.J. (Juan José)|||/items/880171e7-189d-482a-8b2b-d381202651d5 Larrayoz-Ilundain, M. (Marta)|||/items/57152b20-367e-4d04-993b-76c3440d745d Santos, S. (S.)|||/items/1e8b6d4d-d624-4182-b622-bcd8c8301cfe Alignani, D.O. (Diego Óscar)|||/items/86bf2300-6dd0-46b3-90d9-270da3841ff0 Vilas, A. (Amaia)|||/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f Perez, C. (Cristina)|||/items/290e09cd-b084-4cdd-b63e-84762b2d923f Gárate-Luzuriaga, S. (Sonia)|||/items/ecc98ec7-7927-4103-868c-c303a9eaea05 Sarvide, S. (Sarai)|||/items/778fe9e0-6619-4699-ac88-8b1f43f83e98 López-de-Arancibia, A. (Aitziber)|||/items/b377c247-0c0c-45e9-81ee-90fbb0fa3c82 Reinhardt, H.C. (Hans Christian)|||/items/790e4698-5c79-4131-9f1d-a219244591b7 Carrasco, Y.R. (Yolanda R.)|||/items/e01cd92c-72b8-4a80-ba76-ee94349ecb7d Sanchez-Garcia, I. (Isidro)|||/items/3bcfd5eb-617b-4b38-8569-360c35cdfa0e Larrayoz-Ilundáin, M.J. (María José)|||/items/7e29cbb9-798d-4830-bfcf-729a99e05d02 Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Motta, M. (Marina)|||/items/29410855-8e1a-48a5-b2c3-69721b40acb2 Tucci, A. (Alessandra)|||/items/2643603e-fd92-4057-91b5-5b06187cef26 Sacco, A. (Antonio)|||/items/878c6ecd-c1ba-492e-8676-41faceb8fa91 Gentile, M. (Massimo)|||/items/5d116392-5a30-4c5e-a813-5555f6094224 Duarte, S. (Sara)|||/items/125634e0-78c6-4b82-939c-d04d09d936f2 Vitoria, H. (Helena)|||/items/662ab02f-fdbf-440e-bf42-353afc739f45 Geraldes, C. (Catarina)|||/items/960f9a28-f03c-4e95-ab92-9f29345125ef Paiva, A. (Artur)|||/items/bc055f50-04c5-4a0b-a986-dceea2e83659 Puig, N. (Noemí)|||/items/6ff3624a-2657-4823-b2a4-68b3f7b42ba2 García-Sanz, R. (Ramón)|||/items/a1eb0718-40a6-4c41-a26a-df95ea92f2b5 Roccaro, A.M. (Aldo M.)|||/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1 Fuerte, G. (Gema)|||/items/0362c90f-d316-460b-ae53-c0ad5c621ecc San-Miguel, J.F. (Jesús F.)|||/items/114f598d-f226-4fa6-aa75-909241328543 Martínez-Climent, J.A. (José Ángel)|||/items/79ffb953-e6d1-4eff-8a96-46162c04d236 Paiva, B. (Bruno)|||/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44e |
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Rodríguez-Díaz, S. (Saray)|||/items/dbb02193-b704-4400-bed5-3eb2b5518a0b |
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Rodríguez-Díaz, S. (Saray)|||/items/dbb02193-b704-4400-bed5-3eb2b5518a0b Celay-Leoz, I. (Ion)|||/items/2e6e988c-469d-484c-8d81-709e742b9cdc Goicoechea, I. (Ibai)|||/items/544dc017-de06-44f7-b32f-9279f853d817 Jiménez, C. (Cristina)|||/items/dc078094-0995-4678-aafa-3fbb8928bef5 Botta, C. (Cirino)|||/items/52fa96dc-28b2-4e6e-b74a-bc804c280646 García-Barchino, M.J. (María José)|||/items/a05fe752-64c5-4987-9f83-5bf26c3a26a6 Garcés-Latre, J.J. (Juan José)|||/items/880171e7-189d-482a-8b2b-d381202651d5 Larrayoz-Ilundain, M. (Marta)|||/items/57152b20-367e-4d04-993b-76c3440d745d Santos, S. (S.)|||/items/1e8b6d4d-d624-4182-b622-bcd8c8301cfe Alignani, D.O. (Diego Óscar)|||/items/86bf2300-6dd0-46b3-90d9-270da3841ff0 Vilas, A. (Amaia)|||/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f Perez, C. (Cristina)|||/items/290e09cd-b084-4cdd-b63e-84762b2d923f Gárate-Luzuriaga, S. (Sonia)|||/items/ecc98ec7-7927-4103-868c-c303a9eaea05 Sarvide, S. (Sarai)|||/items/778fe9e0-6619-4699-ac88-8b1f43f83e98 López-de-Arancibia, A. (Aitziber)|||/items/b377c247-0c0c-45e9-81ee-90fbb0fa3c82 Reinhardt, H.C. (Hans Christian)|||/items/790e4698-5c79-4131-9f1d-a219244591b7 Carrasco, Y.R. (Yolanda R.)|||/items/e01cd92c-72b8-4a80-ba76-ee94349ecb7d Sanchez-Garcia, I. (Isidro)|||/items/3bcfd5eb-617b-4b38-8569-360c35cdfa0e Larrayoz-Ilundáin, M.J. (María José)|||/items/7e29cbb9-798d-4830-bfcf-729a99e05d02 Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Motta, M. (Marina)|||/items/29410855-8e1a-48a5-b2c3-69721b40acb2 Tucci, A. (Alessandra)|||/items/2643603e-fd92-4057-91b5-5b06187cef26 Sacco, A. (Antonio)|||/items/878c6ecd-c1ba-492e-8676-41faceb8fa91 Gentile, M. (Massimo)|||/items/5d116392-5a30-4c5e-a813-5555f6094224 Duarte, S. (Sara)|||/items/125634e0-78c6-4b82-939c-d04d09d936f2 Vitoria, H. (Helena)|||/items/662ab02f-fdbf-440e-bf42-353afc739f45 Geraldes, C. (Catarina)|||/items/960f9a28-f03c-4e95-ab92-9f29345125ef Paiva, A. (Artur)|||/items/bc055f50-04c5-4a0b-a986-dceea2e83659 Puig, N. (Noemí)|||/items/6ff3624a-2657-4823-b2a4-68b3f7b42ba2 García-Sanz, R. (Ramón)|||/items/a1eb0718-40a6-4c41-a26a-df95ea92f2b5 Roccaro, A.M. (Aldo M.)|||/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1 Fuerte, G. (Gema)|||/items/0362c90f-d316-460b-ae53-c0ad5c621ecc San-Miguel, J.F. (Jesús F.)|||/items/114f598d-f226-4fa6-aa75-909241328543 Martínez-Climent, J.A. (José Ángel)|||/items/79ffb953-e6d1-4eff-8a96-46162c04d236 Paiva, B. (Bruno)|||/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44e |
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author |
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Celay-Leoz, I. (Ion)|||/items/2e6e988c-469d-484c-8d81-709e742b9cdc Goicoechea, I. (Ibai)|||/items/544dc017-de06-44f7-b32f-9279f853d817 Jiménez, C. (Cristina)|||/items/dc078094-0995-4678-aafa-3fbb8928bef5 Botta, C. (Cirino)|||/items/52fa96dc-28b2-4e6e-b74a-bc804c280646 García-Barchino, M.J. (María José)|||/items/a05fe752-64c5-4987-9f83-5bf26c3a26a6 Garcés-Latre, J.J. (Juan José)|||/items/880171e7-189d-482a-8b2b-d381202651d5 Larrayoz-Ilundain, M. (Marta)|||/items/57152b20-367e-4d04-993b-76c3440d745d Santos, S. (S.)|||/items/1e8b6d4d-d624-4182-b622-bcd8c8301cfe Alignani, D.O. (Diego Óscar)|||/items/86bf2300-6dd0-46b3-90d9-270da3841ff0 Vilas, A. (Amaia)|||/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14f Perez, C. (Cristina)|||/items/290e09cd-b084-4cdd-b63e-84762b2d923f Gárate-Luzuriaga, S. (Sonia)|||/items/ecc98ec7-7927-4103-868c-c303a9eaea05 Sarvide, S. (Sarai)|||/items/778fe9e0-6619-4699-ac88-8b1f43f83e98 López-de-Arancibia, A. (Aitziber)|||/items/b377c247-0c0c-45e9-81ee-90fbb0fa3c82 Reinhardt, H.C. (Hans Christian)|||/items/790e4698-5c79-4131-9f1d-a219244591b7 Carrasco, Y.R. (Yolanda R.)|||/items/e01cd92c-72b8-4a80-ba76-ee94349ecb7d Sanchez-Garcia, I. (Isidro)|||/items/3bcfd5eb-617b-4b38-8569-360c35cdfa0e Larrayoz-Ilundáin, M.J. (María José)|||/items/7e29cbb9-798d-4830-bfcf-729a99e05d02 Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086 Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Motta, M. (Marina)|||/items/29410855-8e1a-48a5-b2c3-69721b40acb2 Tucci, A. (Alessandra)|||/items/2643603e-fd92-4057-91b5-5b06187cef26 Sacco, A. (Antonio)|||/items/878c6ecd-c1ba-492e-8676-41faceb8fa91 Gentile, M. (Massimo)|||/items/5d116392-5a30-4c5e-a813-5555f6094224 Duarte, S. (Sara)|||/items/125634e0-78c6-4b82-939c-d04d09d936f2 Vitoria, H. (Helena)|||/items/662ab02f-fdbf-440e-bf42-353afc739f45 Geraldes, C. (Catarina)|||/items/960f9a28-f03c-4e95-ab92-9f29345125ef Paiva, A. (Artur)|||/items/bc055f50-04c5-4a0b-a986-dceea2e83659 Puig, N. (Noemí)|||/items/6ff3624a-2657-4823-b2a4-68b3f7b42ba2 García-Sanz, R. (Ramón)|||/items/a1eb0718-40a6-4c41-a26a-df95ea92f2b5 Roccaro, A.M. (Aldo M.)|||/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1 Fuerte, G. (Gema)|||/items/0362c90f-d316-460b-ae53-c0ad5c621ecc San-Miguel, J.F. (Jesús F.)|||/items/114f598d-f226-4fa6-aa75-909241328543 Martínez-Climent, J.A. (José Ángel)|||/items/79ffb953-e6d1-4eff-8a96-46162c04d236 Paiva, B. (Bruno)|||/items/b2c3efc5-27e1-4425-b452-efba1522c1d5 Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44e |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Lymphoplasmacytic lymphoma Mutations MYD88 |
| topic |
Lymphoplasmacytic lymphoma Mutations MYD88 |
| description |
Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88. We observed similar accumulation of random mutations in B lineages from both cohorts and unexpectedly found MYD88(L265P) in normal precursor and mature B lymphocytes from patients with lymphoma. We uncovered genetic and transcriptional pathways driving malignant transformation and leveraged these to model lymphoplasmacytic lymphoma in mice, based on mutated MYD88 in B cell precursors and BCL2 overexpression. Thus, MYD88(L265P) is a preneoplastic event, which challenges the current understanding of lymphomagenesis and may have implications for early detection of B cell lymphomas. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-03-08 2022 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/63093 |
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https://hdl.handle.net/10171/63093 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869421884506898432 |
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Preneoplastic somatic mutations including MYD88(L265P) in lymphoplasmacytic lymphomaRodríguez-Díaz, S. (Saray)|||/items/dbb02193-b704-4400-bed5-3eb2b5518a0bCelay-Leoz, I. (Ion)|||/items/2e6e988c-469d-484c-8d81-709e742b9cdcGoicoechea, I. (Ibai)|||/items/544dc017-de06-44f7-b32f-9279f853d817Jiménez, C. (Cristina)|||/items/dc078094-0995-4678-aafa-3fbb8928bef5Botta, C. (Cirino)|||/items/52fa96dc-28b2-4e6e-b74a-bc804c280646García-Barchino, M.J. (María José)|||/items/a05fe752-64c5-4987-9f83-5bf26c3a26a6Garcés-Latre, J.J. (Juan José)|||/items/880171e7-189d-482a-8b2b-d381202651d5Larrayoz-Ilundain, M. (Marta)|||/items/57152b20-367e-4d04-993b-76c3440d745dSantos, S. (S.)|||/items/1e8b6d4d-d624-4182-b622-bcd8c8301cfeAlignani, D.O. (Diego Óscar)|||/items/86bf2300-6dd0-46b3-90d9-270da3841ff0Vilas, A. (Amaia)|||/items/cebdc859-3ba2-4e25-b0e4-6a230b97a14fPerez, C. (Cristina)|||/items/290e09cd-b084-4cdd-b63e-84762b2d923fGárate-Luzuriaga, S. (Sonia)|||/items/ecc98ec7-7927-4103-868c-c303a9eaea05Sarvide, S. (Sarai)|||/items/778fe9e0-6619-4699-ac88-8b1f43f83e98López-de-Arancibia, A. (Aitziber)|||/items/b377c247-0c0c-45e9-81ee-90fbb0fa3c82Reinhardt, H.C. (Hans Christian)|||/items/790e4698-5c79-4131-9f1d-a219244591b7Carrasco, Y.R. (Yolanda R.)|||/items/e01cd92c-72b8-4a80-ba76-ee94349ecb7dSanchez-Garcia, I. (Isidro)|||/items/3bcfd5eb-617b-4b38-8569-360c35cdfa0eLarrayoz-Ilundáin, M.J. (María José)|||/items/7e29cbb9-798d-4830-bfcf-729a99e05d02Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3bProsper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1Motta, M. (Marina)|||/items/29410855-8e1a-48a5-b2c3-69721b40acb2Tucci, A. (Alessandra)|||/items/2643603e-fd92-4057-91b5-5b06187cef26Sacco, A. (Antonio)|||/items/878c6ecd-c1ba-492e-8676-41faceb8fa91Gentile, M. (Massimo)|||/items/5d116392-5a30-4c5e-a813-5555f6094224Duarte, S. (Sara)|||/items/125634e0-78c6-4b82-939c-d04d09d936f2Vitoria, H. (Helena)|||/items/662ab02f-fdbf-440e-bf42-353afc739f45Geraldes, C. (Catarina)|||/items/960f9a28-f03c-4e95-ab92-9f29345125efPaiva, A. (Artur)|||/items/bc055f50-04c5-4a0b-a986-dceea2e83659Puig, N. (Noemí)|||/items/6ff3624a-2657-4823-b2a4-68b3f7b42ba2García-Sanz, R. (Ramón)|||/items/a1eb0718-40a6-4c41-a26a-df95ea92f2b5Roccaro, A.M. (Aldo M.)|||/items/a520dfdf-e922-49ed-b8f8-dc4cc5bf51f1Fuerte, G. (Gema)|||/items/0362c90f-d316-460b-ae53-c0ad5c621eccSan-Miguel, J.F. (Jesús F.)|||/items/114f598d-f226-4fa6-aa75-909241328543Martínez-Climent, J.A. (José Ángel)|||/items/79ffb953-e6d1-4eff-8a96-46162c04d236Paiva, B. (Bruno)|||/items/b2c3efc5-27e1-4425-b452-efba1522c1d5Lamo-de-Espinosa-Vázquez-de-Sola, J.M. (José María)|||/items/75feb837-6d53-41fe-808d-4b70661db44eLymphoplasmacytic lymphomaMutationsMYD88Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88. We observed similar accumulation of random mutations in B lineages from both cohorts and unexpectedly found MYD88(L265P) in normal precursor and mature B lymphocytes from patients with lymphoma. We uncovered genetic and transcriptional pathways driving malignant transformation and leveraged these to model lymphoplasmacytic lymphoma in mice, based on mutated MYD88 in B cell precursors and BCL2 overexpression. Thus, MYD88(L265P) is a preneoplastic event, which challenges the current understanding of lymphomagenesis and may have implications for early detection of B cell lymphomas.Dadun. Depósito Académico Digital Universidad de Navarra20222022-03-0820222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/63093reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/630932026-06-21T12:47:57Z |
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