Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India

Saliva is a biological fluid that has not been used extensively as a biomonitoring tool in epidemiological studies. This study presents the arsenic (As) concentrations in saliva and urine samples collected from populations of West Bengal, India who had been previously exposed to high As levels in th...

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Autores: Bhowmick, Subhamoy, Halder, Dipti, Kumar, Amit, Saha, Debasree, Iglesias Juncà, Mònica, Nriagu, Jerome, Guha Mazumder, Debendra Nath, Román-Ross, Gabriela, Chatterjee, Debashis
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/11951
Acesso em linha:http://hdl.handle.net/10256/11951
Access Level:acceso embargado
Palavra-chave:Marcadors bioquímics
Biochemical markers
Arsènic
Arsenic
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spelling Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, IndiaBhowmick, SubhamoyHalder, DiptiKumar, AmitSaha, DebasreeIglesias Juncà, MònicaNriagu, JeromeGuha Mazumder, Debendra NathRomán-Ross, GabrielaChatterjee, DebashisMarcadors bioquímicsBiochemical markersArsènicArsenicSaliva is a biological fluid that has not been used extensively as a biomonitoring tool in epidemiological studies. This study presents the arsenic (As) concentrations in saliva and urine samples collected from populations of West Bengal, India who had been previously exposed to high As levels in their drinking water. We found a significant (p < 0.05) association between the Log transformed Daily Ingestion of As (μg day-1) and the As concentration in saliva (r = 0.68). Additionally, As concentration of saliva and urine also had a significant positive correlation (r = 0.60, p < 0.05). Male participants, smokers, and cases of skin lesion were independently and significantly associated with an increase in salivary As. Thus our findings show that saliva is a useful biomarker of As exposure in the study population. The study also advocates that measurement of the forms of As in saliva may additionally provide insight into the internal dose and any individual differences in susceptibility to As exposureThe present study was funded by Trehan Foundation to the Center for South Asian Studies, University of Michigan, USA. S.B. and D.H. would like to acknowledge Erasmus Mundus External Cooperation Window (EMECW Action II) Program EURINDIA for providing their respective Doctoral Scholarship. The support from Spanish National Research Programme (CGL2010-22168-C03-03) is also duly acknowledged. The authors would also like to acknowledge the support of Mr. Prabir Kr. Das, Mr. Barun Mitra, and Dr. Nilima Ghosh for their assistance during field work. D.C. acknowledges the support of the DST-FIST and UGC-SAP program of Department of Chemistry, University of KalyaniAmerican Chemical Society (ACS)Ministerio de Ciencia e Innovación (Espanya)infoinfo2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10256/11951http://hdl.handle.net/10256/11951© Environmental Science and Technology, 2013, vol. 47, núm. 7, p. 3326-3332Articles publicats (D-Q)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1021/es303756sinfo:eu-repo/semantics/altIdentifier/issn/0013-936Xinfo:eu-repo/semantics/altIdentifier/eissn/1520-5851info:eu-repo/grantAgreement/MICINN//CGL2010-22168-C03-02Tots els drets reservatsinfo:eu-repo/semantics/embargoedAccessoai:recercat.cat:10256/119512026-05-29T05:05:01Z
dc.title.none.fl_str_mv Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
title Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
spellingShingle Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
Bhowmick, Subhamoy
Marcadors bioquímics
Biochemical markers
Arsènic
Arsenic
title_short Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
title_full Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
title_fullStr Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
title_full_unstemmed Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
title_sort Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India
dc.creator.none.fl_str_mv Bhowmick, Subhamoy
Halder, Dipti
Kumar, Amit
Saha, Debasree
Iglesias Juncà, Mònica
Nriagu, Jerome
Guha Mazumder, Debendra Nath
Román-Ross, Gabriela
Chatterjee, Debashis
author Bhowmick, Subhamoy
author_facet Bhowmick, Subhamoy
Halder, Dipti
Kumar, Amit
Saha, Debasree
Iglesias Juncà, Mònica
Nriagu, Jerome
Guha Mazumder, Debendra Nath
Román-Ross, Gabriela
Chatterjee, Debashis
author_role author
author2 Halder, Dipti
Kumar, Amit
Saha, Debasree
Iglesias Juncà, Mònica
Nriagu, Jerome
Guha Mazumder, Debendra Nath
Román-Ross, Gabriela
Chatterjee, Debashis
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (Espanya)
dc.subject.none.fl_str_mv Marcadors bioquímics
Biochemical markers
Arsènic
Arsenic
topic Marcadors bioquímics
Biochemical markers
Arsènic
Arsenic
description Saliva is a biological fluid that has not been used extensively as a biomonitoring tool in epidemiological studies. This study presents the arsenic (As) concentrations in saliva and urine samples collected from populations of West Bengal, India who had been previously exposed to high As levels in their drinking water. We found a significant (p < 0.05) association between the Log transformed Daily Ingestion of As (μg day-1) and the As concentration in saliva (r = 0.68). Additionally, As concentration of saliva and urine also had a significant positive correlation (r = 0.60, p < 0.05). Male participants, smokers, and cases of skin lesion were independently and significantly associated with an increase in salivary As. Thus our findings show that saliva is a useful biomarker of As exposure in the study population. The study also advocates that measurement of the forms of As in saliva may additionally provide insight into the internal dose and any individual differences in susceptibility to As exposure
publishDate 2013
dc.date.none.fl_str_mv 2013
info
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/11951
http://hdl.handle.net/10256/11951
url http://hdl.handle.net/10256/11951
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/es303756s
info:eu-repo/semantics/altIdentifier/issn/0013-936X
info:eu-repo/semantics/altIdentifier/eissn/1520-5851
info:eu-repo/grantAgreement/MICINN//CGL2010-22168-C03-02
dc.rights.none.fl_str_mv Tots els drets reservats
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Tots els drets reservats
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society (ACS)
publisher.none.fl_str_mv American Chemical Society (ACS)
dc.source.none.fl_str_mv © Environmental Science and Technology, 2013, vol. 47, núm. 7, p. 3326-3332
Articles publicats (D-Q)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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