Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study

(1) Background: Atherosclerosis is a leading cause of vascular death worldwide. High urinary phosphate has recently been identified as a cardiovascular risk factor, but its role has not been fully established. The aim of this study was to investigate the association between urinary phosphate and sub...

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Authors: Torrijo-Belanche, Carolina, Moreno-Franco, Belén, Laclaustra, Martín, Gimeno-Ruiz, Sofía, Calvo-Galiano, Naiara, Rey-García, Jimena, Guallar-Castillón, Pilar
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad de Zaragoza
Repository:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:144846
Online Access:http://zaguan.unizar.es/record/144846
Access Level:Open access
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spelling Urinary Phosphate and Subclinical Atherosclerosis: The AWHS StudyTorrijo-Belanche, CarolinaMoreno-Franco, BelénLaclaustra, MartínGimeno-Ruiz, SofíaCalvo-Galiano, NaiaraRey-García, JimenaGuallar-Castillón, Pilar(1) Background: Atherosclerosis is a leading cause of vascular death worldwide. High urinary phosphate has recently been identified as a cardiovascular risk factor, but its role has not been fully established. The aim of this study was to investigate the association between urinary phosphate and subclinical atherosclerosis in the carotid, femoral as well as coronary territories; (2) Methods: We performed a cross-sectional analysis of a sample of 1169 middle-aged men, aged 50.9 years (SD 3.7), without previous cardiovascular disease, belonging to the Aragon Workers Health Study (AWHS). Urinary phosphate was analyzed in urine samples using the Fiske-Subbarow method. The presence of carotid plaque and femoral plaque was assessed by ultrasound and coronary artery calcium score (CACS) by computed tomography. Demographic, anthropometric and clinical data were collected at annual medical examinations. Logistic regression models were used to estimate the prevalence of adjusted atherosclerosis in the different vascular arteries; (3) Results: A significant inverse association was observed between urinary phosphate and subclinical atherosclerosis in the carotid [OR 95% CI 0.69 (0.49–0.99)] and coronary (CACS > 200) [OR 95% CI 0.46 (0.23–0.88)] arteries; however, no statistically significant association was found between urinary phosphate and the presence of atheroma plaques in the femoral territory [OR 1.02 (0.72–1.45)]; (4) Conclusions: In middle-aged men, a higher urinary phosphate concentration is associated with a lower prevalence of subclinical carotid and coronary atherosclerosis compared with those with a lower urinary phosphate concentration.2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/144846reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/ISCIII-FEDER-FSE/FISinfo:eu-repo/grantAgreement/ES/ISCIII/FISinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1448462026-05-29T13:59:51Z
dc.title.none.fl_str_mv Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
title Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
spellingShingle Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
Torrijo-Belanche, Carolina
title_short Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
title_full Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
title_fullStr Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
title_full_unstemmed Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
title_sort Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study
dc.creator.none.fl_str_mv Torrijo-Belanche, Carolina
Moreno-Franco, Belén
Laclaustra, Martín
Gimeno-Ruiz, Sofía
Calvo-Galiano, Naiara
Rey-García, Jimena
Guallar-Castillón, Pilar
author Torrijo-Belanche, Carolina
author_facet Torrijo-Belanche, Carolina
Moreno-Franco, Belén
Laclaustra, Martín
Gimeno-Ruiz, Sofía
Calvo-Galiano, Naiara
Rey-García, Jimena
Guallar-Castillón, Pilar
author_role author
author2 Moreno-Franco, Belén
Laclaustra, Martín
Gimeno-Ruiz, Sofía
Calvo-Galiano, Naiara
Rey-García, Jimena
Guallar-Castillón, Pilar
author2_role author
author
author
author
author
author
description (1) Background: Atherosclerosis is a leading cause of vascular death worldwide. High urinary phosphate has recently been identified as a cardiovascular risk factor, but its role has not been fully established. The aim of this study was to investigate the association between urinary phosphate and subclinical atherosclerosis in the carotid, femoral as well as coronary territories; (2) Methods: We performed a cross-sectional analysis of a sample of 1169 middle-aged men, aged 50.9 years (SD 3.7), without previous cardiovascular disease, belonging to the Aragon Workers Health Study (AWHS). Urinary phosphate was analyzed in urine samples using the Fiske-Subbarow method. The presence of carotid plaque and femoral plaque was assessed by ultrasound and coronary artery calcium score (CACS) by computed tomography. Demographic, anthropometric and clinical data were collected at annual medical examinations. Logistic regression models were used to estimate the prevalence of adjusted atherosclerosis in the different vascular arteries; (3) Results: A significant inverse association was observed between urinary phosphate and subclinical atherosclerosis in the carotid [OR 95% CI 0.69 (0.49–0.99)] and coronary (CACS > 200) [OR 95% CI 0.46 (0.23–0.88)] arteries; however, no statistically significant association was found between urinary phosphate and the presence of atheroma plaques in the femoral territory [OR 1.02 (0.72–1.45)]; (4) Conclusions: In middle-aged men, a higher urinary phosphate concentration is associated with a lower prevalence of subclinical carotid and coronary atherosclerosis compared with those with a lower urinary phosphate concentration.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/144846
url http://zaguan.unizar.es/record/144846
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FSE/FIS
info:eu-repo/grantAgreement/ES/ISCIII/FIS
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
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