Long non-coding RNAs as a source of new peptides

Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we tes...

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Detalles Bibliográficos
Autores: Ruiz Orera, Jorge, 1988-, Messeguer, Xavier, Subirana, Juan A., Albà Soler, Mar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/32245
Acceso en línea:http://hdl.handle.net/10230/32245
http://dx.doi.org/10.7554/eLife.03523
Access Level:acceso abierto
Palabra clave:RNA no missatgers
Pèptids
Proteïnes -- Síntesi
Genètica
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repository_id_str
spelling Long non-coding RNAs as a source of new peptidesRuiz Orera, Jorge, 1988-Messeguer, XavierSubirana, Juan A.Albà Soler, MarRNA no missatgersPèptidsProteïnes -- SíntesiGenèticaDeep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes. The patterns of ribosome protection are consistent with the translation of short peptides. lncRNAs show similar coding potential and sequence constraints than evolutionary young protein coding sequences, indicating that they play an important role in de novo protein evolutionThis work was funded by Ministerio de Economía y Competitividad (BFU2012-36820 and TIN2013-45732-C4-3-P) and Fundació ICREA (MMA)eLife201720172014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/32245http://dx.doi.org/10.7554/eLife.03523reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésElife. 2014 Sep 16;3:e03523info:eu-repo/grantAgreement/ES/1PE/BFU2012-36820info:eu-repo/grantAgreement/ES/1PE/TIN2013-45732-C4-3-P© Jorge Ruiz-Orera et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are creditedhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/322452026-05-29T05:05:01Z
dc.title.none.fl_str_mv Long non-coding RNAs as a source of new peptides
title Long non-coding RNAs as a source of new peptides
spellingShingle Long non-coding RNAs as a source of new peptides
Ruiz Orera, Jorge, 1988-
RNA no missatgers
Pèptids
Proteïnes -- Síntesi
Genètica
title_short Long non-coding RNAs as a source of new peptides
title_full Long non-coding RNAs as a source of new peptides
title_fullStr Long non-coding RNAs as a source of new peptides
title_full_unstemmed Long non-coding RNAs as a source of new peptides
title_sort Long non-coding RNAs as a source of new peptides
dc.creator.none.fl_str_mv Ruiz Orera, Jorge, 1988-
Messeguer, Xavier
Subirana, Juan A.
Albà Soler, Mar
author Ruiz Orera, Jorge, 1988-
author_facet Ruiz Orera, Jorge, 1988-
Messeguer, Xavier
Subirana, Juan A.
Albà Soler, Mar
author_role author
author2 Messeguer, Xavier
Subirana, Juan A.
Albà Soler, Mar
author2_role author
author
author
dc.subject.none.fl_str_mv RNA no missatgers
Pèptids
Proteïnes -- Síntesi
Genètica
topic RNA no missatgers
Pèptids
Proteïnes -- Síntesi
Genètica
description Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes. The patterns of ribosome protection are consistent with the translation of short peptides. lncRNAs show similar coding potential and sequence constraints than evolutionary young protein coding sequences, indicating that they play an important role in de novo protein evolution
publishDate 2014
dc.date.none.fl_str_mv 2014
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/32245
http://dx.doi.org/10.7554/eLife.03523
url http://hdl.handle.net/10230/32245
http://dx.doi.org/10.7554/eLife.03523
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Elife. 2014 Sep 16;3:e03523
info:eu-repo/grantAgreement/ES/1PE/BFU2012-36820
info:eu-repo/grantAgreement/ES/1PE/TIN2013-45732-C4-3-P
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife
publisher.none.fl_str_mv eLife
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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